Miami Marlins vs Cleveland Guardians Prediction, Preview and Odds - 08/13/2025

Game Time: 6:40 pm ET, Wednesday, August 13, 2025

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  FDSFL, CLEGUARDIANS.tv 

DraftKings:  Moneyline odds:  Marlins +104, Guardians -126; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Marlins +105, Guardians -125; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Marlins +105, Guardians -125; Over/Under:  7.5 runs

Miami Marlins:  57-61 (3rd place, NL East)

Cleveland Guardians:  61-56 (2nd place, AL Central)

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Miami Marlins:  4-6 last 10

Cleveland Guardians:  8-2 last 10

The Marlins are entering this series off a loss and lost their 5-game series against the Atlanta Braves 4-1 in their last series. They enter this game with a 57-61 record overall and have a road record of 29-30. This is the 2nd game of a 3-game series with the Guardians on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 18th in the MLB with a .709 OPS. Janson Junk is their starting pitcher on Tuesday while Eury Pérez is making his start in this game on Wednesday. He is 4-3 with a 3.25 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 3 HR, and 2 BB with 1 SO on 7 hits through 5.1 IP against the Atlanta Braves.

The Guardians are entering this series off a loss and won their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 61-56 record overall and have a home record of 29-27. This is the 2nd game of a 3-game series with the Marlins on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 27th in the MLB with a .678 OPS. Logan Allen is their starting pitcher on Tuesday while Gavin Williams is making his start in this game on Wednesday. He is 7-4 with a 3.17 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 4 walks with 6 strikeouts on 1 hit through 8.2 innings pitched against the New York Mets.

The current betting odds have the Guardians listed as a slight favorite in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 61-56 record overall which has them right near the top of the AL Central and in the Wild Card race. They have also looked good in their own ballpark this year with their 29-27 home record. Meanwhile, the Marlins haven't looked great in their games this season with their 57-61 record overall which has them right in the middle of the NL East. They haven't been a great road team either with their 29-30 road record this year. The Guardians are still alive in the Wild Card race and lately they have looked really good. They are 8-2 in their last 10 games and have been red hot lately while the Marlins are 4-6 in their last 10 and have cooled off since their hot streak. The Marlins are going with Perez in this one and he has looked great this season. He is 4-3 with a 3.25 ERA and hasn't been giving up many runs. He is coming off a terrible start though in which he gave up 5 earned runs and even the team has been struggling with him lately, losing 3 games in a row now with him on the mound. The Guardians are going with Williams in this one and he has also looked great this season. He is 7-4 with a 3.17 ERA and he hasn't been giving up many runs lately. He is coming off another great start in which he gave up 1 earned run and the team has won 2 games in a row now with him starting too. The Guardians have been the hotter team lately and they have the edge at home with Williams starting. The best way to place a bet here is on the Guardians to win this game. 

Marlins Guardians Prediction:  Our MLB Pick for Wednesday, August 13, 2025 (6:40 pm ET start time) is Guardians 4 Marlins 2.

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Miami Marlins: 24-16 (+12.8 units) on the moneyline against AL Central opponents. 203-240 (+9.2 units) on the moneyline in all games. 99-123 (+20.3 units) on the moneyline in road games. 23-13 UNDER against AL Central opponents.

Cleveland Guardians: 61-70 (-13 units) on the moneyline in an inter-league game. 167-171 (-10.4 units) on the moneyline vs. good fielding teams - averaging 0.6 errors/game or less. 17-33 (-14.3 units) on the moneyline vs. an NL starting pitcher whose WHIP is 1.250 or better. 35-15 UNDER vs. an NL starting pitcher whose WHIP is 1.250 or better.

Miami Marlins:  J. Tinoco (RP) Sixty Day IL - Forearm. C. Norby (3B) Ten Day IL - Wrist. M. Meyer (SP) Sixty Day IL - Hip. R. Weathers (SP) Sixty Day IL - Lat. G. Conine (LF) Sixty Day IL - Arm. A. Nardi (RP) Sixty Day IL - Back. B. Garrett (SP) Sixty Day IL - Elbow.

Cleveland Guardians:  L. Thomas (CF) Ten Day IL - Foot. W. Brennan (RF) Sixty Day IL - Forearm. A. Walters (RP) Sixty Day IL - Lat. B. Lively (SP) Sixty Day IL - Forearm. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

“He’s running high-quality at-bats. He’s using the whole field, and as he’s settled in now, I think we’re seeing what he’s capable of on the bases.” - Clayton McCullough on Jakob Marsee in their series against the Braves. 

“[He] pitched really well but [he also] felt great, so that's a really good sign.” - Stephen Vogt on John Means working his way back from an injury. 

Xavier Edwards (S) 2B

Heriberto Hernández (R) RF

Kyle Stowers (L) DH

Otto Lopez (R) SS

Dane Myers (R) LF

Eric Wagaman (R) 1B

Derek Hill (R) CF

Liam Hicks (L) C

Javier Sanoja (R) 3B

Steven Kwan (L) LF

Daniel Schneemann (L) 3B

José Ramírez (S) DH

Kyle Manzardo (L) 1B

Gabriel Arias (R) SS

Angel Martínez (S) CF

C.J. Kayfus (L) RF

Brayan Rocchio (S) 2B

Austin Hedges (R) C

Batting Average:  Rob Brantly (.429)

Hits:  Xavier Edwards (127)

Home Runs:  Kyle Stowers (25)

RBI:  Kyle Stowers (71)

Stolen Bases:  Xavier Edwards (22)

Wins:  Ronny Henriquez (6)

Saves:  Calvin Faucher (11)

ERA:  Freddy Tarnok (0.00)

Batting Average:  José Ramírez (.289)

Hits:  José Ramírez (125)

Home Runs:  José Ramírez (23)

RBI:  José Ramírez (61)

Stolen Bases:  José Ramírez (33)

Wins:  Tanner Bibee (8)

Saves:  Emmanuel Clase (24)

ERA:  Carlos Hernández (0.00)

Managers:

Miami Marlins: Clayton McCullough (1st season)

Cleveland Guardians: Stephen Vogt (2nd season)