Miami Dolphins vs Indianapolis Colts Prediction, Preview and Odds - 09/07/2025

Game Time: 1:00 pm ET, Sunday, September 7, 2025

Venue:  Lucas Oil Stadium, Indianapolis, IN 

Where to Watch:  CBS

DraftKings:  Point Spread:  Dolphins +1.5, Colts -1.5; Over/Under:  46.5 points

Bet365:  Point Spread:  Dolphins +1.5, Colts -1.5; Over/Under:  46.5 points

BetMGM:  Point Spread:  Dolphins +1.5, Colts -1.5; Over/Under:  47 points

Miami Dolphins:  0-0 (AFC East)

Indianapolis Colts:  0-0 (AFC South)

Do not miss out on our expert handicapper analysis! Jim Feist is on a HOT STREAK in the NFL on a 105-87-3 NFL RUN for +$7,960 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Miami Dolphins:  N/A

Indianapolis Colts:  N/A

The Dolphins finished last season with an 8-9 record overall and they were 3-3 in their division games too. They had a 5-3 record in their home games and had a 3-6 record in their road games where they will be in this game. Last season, their offense was averaging 20.3 points per game and their defense was allowing an average of 21.4 points per game. Their offense was also averaging 325.4 yards per game and their defense was allowing an average of 314.4 yards per game. Tua Tagovailoa led the team in passing yards with 2,867, De'Von Achane led the team in rushing yards with 907, and Tyreek Hill led the team in receiving yards with 959.

The Colts finished last season with an 8-9 record overall and they were 3-3 in their division games too. They had a 5-3 record in their home games and had a 3-6 record in their road games where they will be in this game. Last season, their offense was averaging 22.2 points per game and their defense was allowing an average of 25.1 points per game. Their offense was also averaging 334.8 yards per game and their defense was allowing an average of 361.2 yards per game. Anthony Richardson led the team in passing yards with 1,814, Jonathan Taylor led the team in rushing yards with 1,431, and Alec Pierce led the team in receiving yards with 824.

The current betting odds have the Dolphins listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Dolphins didn't have a great season last year, finishing 8-9 overall and they missed the playoffs. They were dealing with a lot of injuries last season though and they will be looking to put that year behind them. The team is healthy again for the most part and they will be looking to have a strong start to the season after a disappointing year. The defense wasn't bad last season since they weren't giving up a ton of points in their games, it was the offense that was the issue. Now they are healthy again and the offense definitely has the talent to put up points. Meanwhile, the Colts didn't have a great season either, going 8-9 overall and also missing the playoffs. They had a rollercoaster of a season from week to week with Anthony Richardson at QB, but now they are opting for a more experienced Daniel Jones. Jones definitely brings experience to the table for the Colts, but they have also had a lot of veteran QB's over the last few seasons and it hasn't helped much. Jones doesn't really have a proven track record either from his days on the Giants and this is a completely new system that he had to learn so the Dolphins have a big advantage offensively in this season opener. The Colts didn't have a great defense last season either so even with some improvement, the Dolphins should have the edge here with a more consistent offense. The best way to place a bet here is on the Dolphins to cover the spread in this game. 

Dolphins Colts Prediction:  Our NFL Pick for Sunday, September 7, 2025 (1:00 pm ET start time) is Dolphins 21 Colts 13.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Miami Dolphins Indianapolis Colts prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Miami Dolphins: 0-5 ATS against AFC South division opponents. 3-9 ATS as a road underdog of 7 points or less. 1-5 ATS in a road game where the total is between 42.5 and 49 points. 11-6 UNDER in games where the line is +3 to -3. 5-1 UNDER in a road game where the total is between 42.5 and 49 points.

Indianapolis Colts: 8-5 ATS as a favorite. 12-7 ATS in games where the line is +3 to -3. 15-9 ATS against conference opponents. 73-51 1H UNDER in a home game where the total is greater than or equal to 45.5.

Miami Dolphins:  None.

Indianapolis Colts:  None.

"I think Ollie did a very good job today of mastering the non-on-ball assignments. I thought he did a better job with that. I thought he competed. For the most part, I think his tracks were good and his assignments were 100%. So it was a good day for a rookie back in terms of getting his feet wet. It didn't look too big for him." - Mike McDaniel on Ollie Gordon’s performance in the preseason.

“We'll work through that tomorrow. I would expect them to be back next week for sure, but they're still working through it. But they're all progressing really well.” - Shane Steichen on both Josh Downs and Nick Cross returning from injury for the season opener. 

WR Waddle, Jaylen

WR Hill, Tyreek

WR Washington, Malik

TE Waller, Darren

QB Tagovailoa, Tua

RB Achane, De'Von

FB Ingold, Alec

WR Pittman Jr., Michael

WR Pierce, Alec

WR Downs, Josh

TE Warren, Tyler

QB Jones, Daniel

RB Taylor, Jonathan

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Miami Dolphins: Mike McDaniel (4th season)

Indianapolis Colts: Shane Steichen (3rd season)