Memphis Grizzlies vs Minnesota Timberwolves Prediction, Preview and Odds - 12/17/2025

Game Time: 8:00 pm ET, Wednesday, December 17, 2025

Venue:  Target Center, Minneapolis, MN

Where to Watch:  NBA TV

DraftKings:  Point Spread:  Grizzlies +8.5, Timberwolves -8.5; Over/Under:  235.5 points

Bet365:  Point Spread:  Grizzlies +8.5, Timberwolves -8.5; Over/Under:  235.5 points

BetMGM:  Point Spread:  Grizzlies +8.5, Timberwolves -8.5; Over/Under:  235.5 points

Memphis Grizzlies:  12-14 (3rd place, Southwest Division)

Minnesota Timberwolves:  17-9 (3rd place, Northwest Division)

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Memphis Grizzlies:  7-3 last 10

Minnesota Timberwolves:  7-3 last 10

The Grizzlies are entering this game with a 12-14 record overall this season and they are 6-7 in their road games this season where they will be in this game. They are entering this game off a win against the Los Angeles Clippers. Jaren Jackson Jr. led the team in points in that game with 31 while Cam Spencer was next on the team with 27 points. Cam Spencer and Kentavious Caldwell-Pope each led the team in assists in that game with 6 while Kentavious Caldwell-Pope led the team in rebounds with 7. They were 52.3% from the field, 41% from 3-point range, and 88.2% from the free throw line with their shots in that game. Their offense is averaging 114.3 PPG and their defense is allowing their opponents to average 115.4 PPG against them. The Grizzlies have an ATS record of 12-14 this season and their O/U record is 9-17.

The Timberwolves are entering this game with a 17-9 record overall this season and they are 9-4 in their home games this season where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the Golden State Warriors and the Sacramento Kings. Julius Randle led the team in points in that game with 24 while Jaden McDaniels was next on the team with 21 points. Donte DiVincenzo led the team in assists in that game with 6 while Rudy Gobert led the team in rebounds with 12. They were 45.7% from the field, 32.4% from 3-point range, and 70.4% from the free throw line with their shots in that game. Their offense is averaging 119.8 PPG and their defense is allowing their opponents to average 114.5 PPG against them. The Timberwolves have an ATS record of 10-16 this season and their O/U record is 13-13.

The current betting odds have the Timberwolves listed as an 8.5 point favorite in this game according to Draftkings Sportsbook. The Timberwolves have looked really good in their games this season with their 17-9 record overall which has them in the top half of the West. They have looked great on their home court too with their 9-4 home record this year. Meanwhile, the Grizzlies haven't looked good in their games this season with their 12-14 record overall which has them in the bottom half of the West. They haven't been a great road team either with their 6-7 road record this year. The Grizzlies have looked a lot better lately though, going 7-3 in their last 10 games and coming off a win over the Clippers in their last one. As good as they have been lately, they have also been beating up on bad teams during this run and now they have to play against one of the best in the West. The Timberwolves have also been rolling in their games lately as they are 7-3 in their last 10 and have some momentum on their side with 2 wins in a row now. They are off a big win over the Kings in their last one and they have been blowing out a lot of teams too. Edwards is dealing with an injury, but the Timberwolves still have a ton of talent without him and have been a strong force in the West over the last few seasons. The Grizzlies have looked a lot better lately while beating up on weaker teams, but the Timberwolves are a much stronger team that has been great on their home court this year so look for the Timberwolves to continue rolling at home. The best way to place a bet here is on the Timberwolves to cover the spread in this game. 

Grizzlies Timberwolves Prediction:  Our NBA Pick for Wednesday, December 17, 2025 (8:00 pm ET start time) is Timberwolves 132 Grizzlies 116.

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Memphis Grizzlies: 14-29 ATS against Northwest division opponents. 11-23 ATS when playing against a good team (Win Pct. 60% to 70%). 19-37 ATS versus good teams - outscoring their opponents by 3+ points/game. 39-28 OVER as a road underdog.

Minnesota Timberwolves: 5-2 ATS in a home game where the total is greater than or equal to 230. 39-26 ATS when playing only their 2nd game in 5 days. 30-15 OVER against Southwest division opponents. 21-12 OVER at home when playing only their 2nd game in 5 days. 

Memphis Grizzlies:  J. Konchar (SG) Out - Thumb. B. Clarke (PF) Out - Knee. Z. Edey (C) Out - Ankle. T. Jerome (SG) Out - Calf. J. Small (PG) Out - Toe. S. Pippen Jr. (PG) Out - Toe.

Minnesota Timberwolves:  M. Conley (PG) Day To Day - Achilles. A. Edwards (SG) Day To Day - Foot.

“We started the season essentially without point guards and without two of our key players. That put us in a very difficult spot early on.” - Tuomas Iisalo on his team’s resilience this season.

"It's definitely improving. He's still day to day. We have practice here this morning, and we'll see what he looks like coming in. But he was able to move around and get up some shots yesterday. We're headed in the right direction, but I'm not sure of an exact return time just yet." - Chris Finch on the injury to Anthony Edwards.

PG Ja Morant 

SG Cedric Coward

SF Jaylen Wells

PF Santi Aldama

C Jaren Jackson Jr.

PG Donte DiVincenzo

SG Anthony Edwards

SF Jaden McDaniels

PF Julius Randle

C Rudy Gobert

PPG: Ja Morant (17.7)

APG: Ja Morant (7.5)

Reb/G: Zach Edey (11.1)

PPG: Anthony Edwards (28.7)

APG: Julius Randle (5.8)

Reb/G: Rudy Gobert (10.3)

Coaches:

Memphis Grizzlies: Tuomas Iisalo (2nd season)

Minnesota Timberwolves: Chris Finch (6th season)