LSU Tigers vs Mississippi Rebels Prediction, Picks and Game Preview - 09/27/2025

Game Time: 3:30 pm ET, Saturday, September 27, 2025

Venue:  Vaught Hemingway Stadium, Oxford, MS

Where to Watch:  ABC

DraftKings:  Point Spread:  LSU +1.5, Ole Miss -1.5; Over/Under:  54.5 points

Bet365:  Point Spread:  LSU +1.5, Ole Miss -1.5; Over/Under:  54.5 points

BetMGM:  Point Spread:  LSU +1.5, Ole Miss -1.5; Over/Under:  54.5 points

LSU Tigers:  4-0 (1-0) (6th place, SEC)

Mississippi Rebels:  4-0 (2-0) (1st place, SEC)

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LSU Tigers:  won their last game at home against the Southeastern Louisiana Lions 56-10.

Mississippi Rebels:  won their last game at home against the Tulane Green Wave 45-10.

LSU is entering this game with a 4-0 record overall and they have a 1-0 record in their conference games too. They are 3-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Southeastern Louisiana 56-10. Garrett Nussmeier was the starting QB and he completed 25/31 passes for 273 passing yards, 3 touchdowns, and 0 interceptions. Ju'Juan Johnson led the team in rushing yards with 43 and 2 TDs. Bauer Sharp led the receivers with 73 receiving yards on 5 receptions and 1 TD. Dashawn McBryde led the defense in that game with 4 solo tackles and 0 assisted tackles while Damien Shanklin led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

 

 

 

Ole Miss is entering this game with a 4-0 record overall and they have a 2-0 record in their conference games too. They are 3-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Tulane 45-10. Trinidad Chambliss was the starting QB and he completed 17/27 passes for 307 passing yards, 2 touchdowns, and 0 interceptions. Trinidad Chambliss led the team in rushing yards with 112. Deuce Alexander led the receivers with 94 receiving yards on 4 receptions and 1 TD. Jaden Yates led the defense in that game with 4 solo tackles and 7 assisted tackles while no one on the defense recorded a sack for them. Cedrick Beavers came away with the only interception for them in that one.

The current betting odds have LSU listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. LSU has looked great in their games this season with their 4-0 record overall and they are ranked like one of the best teams in the nation too. They have a good win over Clemson in their season opener which doesn't look as good now, but they also have a tough conference win over Florida. They definitely haven't had an easy schedule to open up the season so they have already been tested for this game. Their offense hasn't looked great at times, but they still have a ton of talent that will have success against this Ole Miss defense that isn't great. The defense for LSU has also been great in every game this year and they will have a big say in what happens here. Meanwhile, Ole Miss has looked great in their games this season with their 4-0 record overall and their 2-0 conference record which has them right at the top of the SEC. Now they are off a crushing win over Tulane in their last one, but their 2 wins in the SEC were against some of the bottom half teams so this is going to be a big step up in talent here. Ole Miss has a great offense and they usually do under Lane Kiffin, but they still have a big issue defensively and that is what will get them into trouble here. LSU isn't going to run into the problems on offense that Ole Miss is going to run into against this LSU defense that is one of the best in the SEC. The best way to place a bet here is on LSU to cover the spread in this game. 

LSU Mississippi Prediction:  Our NCAAF Pick for Saturday, September 27, 2025 (3:30 pm ET start time) is LSU 27 Ole Miss 17.

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LSU Tigers: 1-6 ATS when the line is +3 to -3. 1-4 ATS on the road after 3 or more consecutive straight up wins. 4-9 ATS in September games. 25-15 UNDER in a road game where the total is between 49.5 and 56. 

Mississippi Rebels: 18-10 ATS in all lined games. 9-5 ATS as a home favorite. 8-4 ATS when playing against a team with a winning record. 16-9 UNDER as a favorite. 12-6 UNDER against conference opponents.

LSU Tigers:  C. Durham (RB) Questionable - Ankle. Z. Williams (DL) Questionable - Undisclosed. T. Green (TE) Questionable - Knee. J. Lindsey (RB) Out - Suspension.

Mississippi Rebels:  J. Braxton (CB) Questionable - Undisclosed. T. Ray (WR) Questionable - Undisclosed.

“We have a standard of how we want to play and I thought we upheld that standard. There is no perfection out there, but there was definitely some progress.” - Brian Kelly after his team’s win against SELA in their last game.

"I’m really proud because we were coming off two hard games and we could have been looking ahead next week to LSU. Our players and coaches came out and took care of business. It was a dominating day against a really well-coached team that plays hard.” - Lane Kiffin after his team’s win against Tulane in their last game. 

WR Thomas, Zavion

WR Anderson, Aaron

WR Hilton Jr., Chris

TE Sharp, Bauer

QB Nussmeier, Garrett

RB Durham, Caden

WR Wallace III, Harrison

WR Stribling, De'Zhaun

WR Lee, Cayden

TE Wright, Dae'Quan

QB Simmons, Austin

RB Lacy, Kewan

Passing: Garrett Nussmeier (962)

Rushing: Caden Durham (213)

Receiving: Aaron Anderson (293)

Touchdowns: Caden Durham (2)

Passing: Trinidad Chambliss (719)

Rushing: Kewan Lacy (358)

Receiving: Harrison Wallace III (343)

Touchdowns: Kewan Lacy (7)

Coaches:

LSU Tigers: Brian Kelly (4th season)

Mississippi Rebels: Lane Kiffin (6th season)