by Rod Pearson
Wednesday, Sep 16, 2026
Game Time: 7:30 pm ET, Saturday, September 19, 2026
Venue: Vaught Hemingway Stadium, Oxford, MS
Where to Watch: ABC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: LSU -3, Ole Miss +3; Over/Under: 58.5 points
Bet365: Point Spread: LSU -3, Ole Miss +3; Over/Under: 58.5 points
BetMGM: Point Spread: LSU -3, Ole Miss +3; Over/Under: 58.5 points
Season Record
LSU Tigers: 2-0 (0-0) (2nd place, SEC)
Mississippi Rebels: 2-0 (0-0) (2nd place, SEC)
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LSU Tigers: won their last game at home against the Louisiana Tech Bulldogs 45-14.
Mississippi Rebels: won their last game at home against the Charlotte 49ers 41-9.
LSU Tigers vs Mississippi Rebels Preview and Analysis
LSU is entering this game with a 2-0 record overall and they have a 0-0 record in their conference games too. They are 2-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against LA Tech 45-14. Sam Leavitt was the starting QB and he completed 25/38 passes for 344 passing yards, 1 touchdown, and 3 interceptions. Dilin Jones led the team in rushing yards with 66. Trey'Dez Green led the receivers with 104 receiving yards on 6 receptions and 1 TD. TJ Dottery led the defense in that game with 9 tackles while Princewill Umanmielen led the defense in sacks with 3. DJ Pickett came away with the only interception for them in that one.
Ole Miss is entering this game with a 2-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Charlotte 41-9. Trinidad Chambliss was the starting QB and he completed 23/26 passes for 225 passing yards, 2 touchdowns, and 0 interceptions. Kewan Lacy led the team in rushing yards with 87 and 2 TDs. Deuce Alexander led the receivers with 76 receiving yards on 8 receptions. Luke Ferrelli and Tah'j Butler each led the defense in that game with 6 tackles while Jordan Renaud led the defense in sacks with 1. Nick Cull came away with the only interception for them in that one.
LSU vs Mississippi Prediction
The current betting odds have Ole Miss listed as a 3 point underdog in this game according to Draftkings Sportsbook. Ole Miss has looked great in their games this season with their 2-0 record overall so far. They have looked good on their home field too with their 1-0 home record this season. Meanwhile, LSU has looked great in their games this season with their 2-0 record overall so far. They haven't played any road games yet and will be playing their 1st road game of the season here. LSU is coming off a 45-14 win over LA Tech in their last one and they have looked great in both games this season. They were supposed to get tested by Clemson in week 1, but they blew by them with a 51-10 win at home. Now this is their 1st road game of the year along with it being their 1st conference game and there is going to be a lot of emotions here. Lane Kiffin is returning to the school he abandoned mid-playoff and Ole Miss is going to make sure to bring their best effort for him. Ole Miss still has a really good RB with Kewan Lacy and they kept Trinidad Chambliss who was one of the most electric QB's in the nation last season. The offense has looked great in both games, coming off a 41-9 win over Charlotte last week, and they did get tested in week 1 with a 41-38 win over a really good Louisville team. This game is going to mean a lot for the players on the field at Ole Miss and they have the edge here with the home advantage. LSU definitely has a ton of talent on offense and defense, but so does Ole Miss and Chambliss is good enough to keep them in the game with better QB play. Chambliss is going to be the key factor in this game as he will be the best player on the field, so look for Ole Miss to put everything that they have into this game to pull off the upset win. The best way to place a bet here is on Ole Miss to cover the spread in this game.
LSU Mississippi Prediction: Our NCAAF Pick for Saturday, September 19, 2026 (7:30 pm ET start time) is Ole Miss 31 LSU 28.
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NCAAF Betting Trends
LSU Tigers: 10-18 ATS in all lined games. 1-7 ATS when the line is +3 to -3. 2-7 ATS when the total is between 56.5 and 63. 17-9 UNDER against FBS division opponents. 6-3 UNDER when the total is between 56.5 and 63.
Mississippi Rebels: 6-3 ATS in a home game where the total is between 56.5 and 63. 30-18 ATS after allowing 14 points or less last game. 8-4 UNDER when the total is between 56.5 and 63. 8-4 UNDER after a win by 17 or more points.
Key Injuries
LSU Tigers: None.
Mississippi Rebels: C. Odom (TE) Out - Undisclosed.
Notable Quotes
“We’re winning by 31 points and we’re really upset. We’ve got a good standard going.” - Lane Kiffin after his team’s win against LA Tech in their last game.
“Two touchdown passes and five scores in six drives. That sounds like Trinidad doesn’t it? That sounds like a normal Saturday. He does it and competes every play.” - Pete Golding after his team’s win against Charlotte in their last game.
Starting Lineups
LSU Tigers
WR Elzy, Malik
WR Wilson III, Eugene
WR Watkins Jr., Winston
TE Green, Trey'Dez
QB Leavitt, Sam
RB Jones, Dilin
Mississippi Rebels
WR Alexander, Deuce
WR Fields, Horatio
WR Cook II, Johntay
TE Hasz, Luke
QB Chambliss, Trinidad
RB Lacy, Kewan
Statistical Leaders
LSU Tigers
Passing: Sam Leavitt (574)
Rushing: Dilin Jones (179)
Receiving: Trey'Dez Green (162)
Touchdowns: Sam Leavitt (5)
Mississippi Rebels
Passing: Trinidad Chambliss (561)
Rushing: Kewan Lacy (148)
Receiving: Deuce Alexander (235)
Touchdowns: Kewan Lacy (3)
Coaches:
LSU Tigers: Lane Kiffin (1st season)
Mississippi Rebels: Pete Golding (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
