LSU Tigers vs Alabama Crimson Tide Prediction, Picks and Game Preview - 11/08/2025

Game Time: 7:30 pm ET, Saturday, November 8, 2025

Venue:  Saban Field at Bryant-Denny Stadium, Tuscaloosa, AL

Where to Watch:  ABC

DraftKings:  Point Spread:  LSU +10, Alabama -10; Over/Under:  49.5 points

Bet365:  Point Spread:  LSU +10, Alabama -10; Over/Under:  49.5 points

BetMGM:  Point Spread:  LSU +10, Alabama -10; Over/Under:  49.5 points

LSU Tigers:  5-3 (2-3) (10th place, SEC)

Alabama Crimson Tide:  7-1 (5-0) (2nd place, SEC)

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LSU Tigers:  lost their last game at home against the Texas A&M Aggies 49-25

Alabama Crimson Tide:  won their last game on the road against the South Carolina Gamecocks 29-22.

LSU is entering this game with a 5-3 record overall and they have a 2-3 record in their conference games too. They are 4-1 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Texas A&M 49-25. Garrett Nussmeier was the starting QB and he completed 22/35 passes for 168 passing yards, 1 touchdown, and 0 interceptions. Harlem Berry led the team in rushing yards with 59 and 1 TD. Barion Brown led the receivers with 60 receiving yards on 4 receptions. A.J. Haulcy led the defense in that game with 7 solo tackles and 5 assisted tackles while no one on the defense recorded a sack for them. A.J. Haulcy and Harold Perkins Jr. each came away with 1 interception for them in that one.

 

 

 

Alabama is entering this game with a 7-1 record overall and they have a 5-0 record in their conference games too. They are 4-0 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against South Carolina 29-22. Ty Simpson was the starting QB and he completed 24/43 passes for 253 passing yards, 2 touchdowns, and 0 interceptions. Jamarion Miller led the team in rushing yards with 26. Daniel Hill led the receivers with 76 receiving yards on 4 receptions. Deontae Lawson and Justin Jefferson each led the defense in that game with 6 solo tackles and 1 assisted tackle while Justin Jefferson and Keon Keeley each led the defense in sacks with 1. D'Shawn Jones came away with the only interception for them in that one.

The current betting odds have Alabama listed as a 10 point favorite in this game according to Draftkings Sportsbook. Alabama has looked really good in their games this season with their 7-1 record overall and their 5-0 conference record which has them right near the top of the SEC. They have looked great on their home field too with their 4-0 home record this season. Meanwhile, LSU has looked good in their games this season with their 5-3 record overall, but their 2-3 conference record has them lower in the SEC. They haven't been a great road team this year either with their 1-2 road record. They are off a 49-25 loss at home to Texas A&M in their last one which led to the team firing Brian Kelly and now they are coming out of their bye week with some new hope, but they still haven't shown much on offense this season. The defense has looked great at times, but they have struggled against better offenses, and their own offense hasn't been able to compete in their games against better opponents. LSU can't really turn this season around either and this might be the toughest game they play all season too. Alabama's only loss this year was on the road against Florida State, but that loss was in their season opener and they have looked like a completely different team lately. This isn't the same team that lost to Florida State as they look like one of the best teams in the SEC now, and they are also coming out of their bye week so they will be ready to take down LSU at home. The best way to place a bet here is on Alabama to cover the spread in this game. 

LSU Alabama Prediction:  Our NCAAF Pick for Saturday, November 8, 2025 (7:30 pm ET start time) is Alabama 41  LSU 17.

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LSU Tigers: 1-4 ATS as a road underdog. 2-5 ATS when the total is between 49.5 and 56. 2-7 ATS when playing against a top-level team (Win Pct. > 75%). 13-7 OVER when playing against a team with a winning record. 5-1 OVER after a game with a turnover margin of +2 or better.

Alabama Crimson Tide: 13-4 ATS as a home favorite. 11-2 ATS after playing their last game on the road. 12-6 ATS when playing against a team with a winning record. 5-2 OVER in a home game where the total is between 49.5 and 56. 9-4 OVER after 3 or more consecutive straight up wins.

LSU Tigers:  C. Curne (OG) Probable - Undisclosed. Z. Weeks (LB) Doubtful - Undisclosed. T. Adams (OG) Out - Undisclosed. G. Reliford (DL) Out - Undisclosed. W. Weeks (LB) Questionable - Ankle. J. Lindsey (RB) Out - Suspension.

Alabama Crimson Tide:  R. Williams (WR) Probable - Undisclosed. D. Kirkpatrick Jr. (CB) Out - Undisclosed. C. Jones (LB) Out - Undisclosed. J. Latham (LB) Out - Neck. Q. Russaw (LB) Out - Leg. D. Lewis Jr. (TE) Questionable - Undisclosed. J. Beaman (DL) Out - Lower Body.

"Nobody’s more disappointed than our football team. Our fan base should be upset. They have every right to be. That second half was unacceptable on any level.” - Brian Kelly after LSU’s loss against Texas A&M in their last game. 

“If you play with confidence, you give yourself a chance.” - Kalen DeBoer after his team’s win against South Carolina in their last game. 

WR Thomas, Zavion

WR Brown, Barion

WR Anderson, Aaron

TE Sharp, Bauer

QB Nussmeier, Garrett

RB Durham, Caden

WR Horton, Isaiah

WR Bernard, Germie

WR Williams, Ryan

TE Lewis Jr., Danny

TE Cuevas, Josh

QB Simpson, Ty

RB Miller, Jam

Passing: Garrett Nussmeier (1,806)

Rushing: Caden Durham (378)

Receiving: Aaron Anderson (382)

Touchdowns: Trey'Dez Green (4)

Passing: Ty Simpson (2,184)

Rushing: Jam Miller (308)

Receiving: Germie Bernard (526)

Touchdowns: Germie Bernard (8)

Coaches:

LSU Tigers: Frank Wilson (Interim)

Alabama Crimson Tide: Kalen DeBoer (2nd season)