Louisiana Tech Bulldogs vs LSU Tigers Prediction, Picks and Game Preview - 09/06/2025

Game Time: 7:30 pm ET, Saturday, September 6, 2025

Venue:  Tiger Stadium, Baton Rouge, LA 

Where to Watch:  ESPN+, SEC Network+

DraftKings:  Point Spread:  LA Tech +37.5, LSU -37.5; Over/Under:  51.5 points

Bet365:  Point Spread:  LA Tech +37, LSU -37; Over/Under:  51.5 points

BetMGM:  Point Spread:  LA Tech +37.5, LSU -37.5; Over/Under:  51.5 points

Louisiana Tech Bulldogs:  1-0 (0-0) (5th place, CUSA)

LSU Tigers:  1-0 (0-0) (13th place, SEC)

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Louisiana Tech Bulldogs:  won their last game at home against the Southeastern Louisiana Lions 24-0.

LSU Tigers:  won their last game on the road against the Clemson Tigers 17-10.

Louisiana Tech is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against SELA 24-0. Trey Kukuk was the starting QB and he completed 14/19 passes for 130 passing yards, 1 touchdown, and 0 interceptions. Clay Thevenin led the team in rushing yards with 61 and 1 TD. Eli Finley led the receivers with 59 receiving yards on 4 receptions. Sifa Leota led the defense in that game with 5 solo tackles and 7 assisted tackles while Mekhi Mason led the defense in sacks with 2. Jakari Foster and Zion Nason each came away with 1 interception for them in that one.

 

 

 

LSU is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Clemson 17-10. Garrett Nussmeier was the starting QB and he completed 28/38 passes for 230 passing yards, 1 touchdown, and 0 interceptions. Caden Durham led the team in rushing yards with 74 and 1 TD. Aaron Anderson led the receivers with 99 receiving yards on 6 receptions. PJ Woodland led the defense in that game with 5 solo tackles and 0 assisted tackles while PJ Woodland and Harold Perkins Jr. each led the defense in sacks with 1. Mansoor Delane came away with the only interception for them in that one.

The current betting odds have LSU listed as a 37.5 point favorite in this game according to Draftkings Sportsbook. LSU is 1-0 overall and they looked great in their season opener. They went on the road against a ranked Clemson opponent and won in their house 17-10. They were the better team throughout the game and their offense looked really good even though they only put up 17 points. Their defense also looked great and was able to shut down a really good Clemson offense in the 2nd half. Brian Kelly finally looks like he has his act together in Baton Rouge and they will definitely be looking to follow up that win with another great performance against a cupcake in their home opener. Meanwhile, LA Tech is also 1-0 overall and their defense looked great in their season opener. They shut out SELA 24-0, but they were also at home against a team from the FCS and the offense didn't look great against that weaker defense. LA Tech could still barely move the ball last week and they are going to have a lot more trouble on the road against this LSU defense. LSU wasn't able to have a big explosive game on offense against that Clemson defense either so they will be looking to run up the score at home. The best way to place a bet here is on LSU to cover the spread in this game. 

Louisiana Tech LSU Prediction:  Our NCAAF Pick for Saturday, September 6, 2025 (7:30 pm ET start time) is LSU 55 LA Tech 3.

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Louisiana Tech Bulldogs: 9-3 ATS as an underdog of 31 or more points. 7-2 OVER as an underdog of 31 or more points. 24-15 OVER off a home win by 17 points or more. 38-25 OVER after a game with a turnover margin of +2 or better.

LSU Tigers: 4-11 ATS off an upset win as a road underdog. 21-33 ATS at home off a road win. 20-9 OVER as a favorite of 31 or more points. 6-3 OVER off an upset win as a road underdog.

Louisiana Tech Bulldogs:  J. Wilkerson (WR) Questionable - Undisclosed.

LSU Tigers:  D. Hill (WR) Out - Hand. M. Van Buren Jr. (QB) Questionable - Undisclosed. J. Lindsey (RB) Out - Suspension. A. Anderson (WR) Questionable - Knee. N. Anderson (WR) Questionable - Concussion.

“They really don’t have any weaknesses, probably the best quarterback in the country." - Sonny Cumbie on his team’s upcoming game against LSU this week. 

“I think getting him out of the pocket and primarily got him out of rhythm. I thought we did that very, very well and we took his running game away. Any quarterback that doesn’t have a running game, it becomes predictable and we had some predictable down the distances because they couldn’t run the football.” - Brian Kelly after his team’s win against Clemson in their last game. 

WR Singleton Jr., Marques

WR Benedix, Dane

WR Latulas, Dedrick

TE Finley, Eli 

QB Kukuk, Trey

RB Wiggins, Omiri

WR Thomas, Zavion

WR Anderson, Aaron

WR Hilton Jr., Chris

TE Sharp, Bauer

QB Nussmeier, Garrett

RB Durham, Caden

Passing: T. Kukuk (126)

Rushing: C. Thevenin (61)

Receiving: E. Finley (59)

Touchdowns: C. Thevenin (1)

Passing: G. Nussmeier (230)

Rushing: C. Durham (74)

Receiving: A. Anderson (99)

Touchdowns: C. Durham (1)

Coaches:

Louisiana Tech Bulldogs: Sonny Cumbie (4th season)

LSU Tigers: Brian Kelly (4th season)