Louisiana Ragin' Cajuns vs Missouri Tigers Prediction, Picks and Game Preview - 09/13/2025

Game Time: 4:00 pm ET, Saturday, September 13, 2025

Venue:  Faurot Field at Memorial Stadium, Columbia, MO

Where to Watch:  ESPN+, SEC Network+

DraftKings:  Point Spread:  ULL +27.5, Mizzou -27.5; Over/Under:  47.5 points

Bet365:  Point Spread:  ULL +27.5, Mizzou -27.5; Over/Under:  47.5 points

BetMGM:  Point Spread:  ULL +27.5, Mizzou -27.5; Over/Under:  47.5 points

Louisiana Ragin' Cajuns:  1-1 (0-0) (6th place, Sun Belt West)

Missouri Tigers:  2-0 (0-0) (4th place, SEC)

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Louisiana Ragin' Cajuns:  won their last game at home against the McNeese State Cowboys 34-10.

Missouri Tigers:  won their last game at home against the Kansas Jayhawks 42-31.

Louisiana-Lafayette is entering this game with a 1-1 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against McNeese State 34-10. Daniel Beale was the starting QB and he completed 14/22 passes for 86 passing yards, 1 touchdown, and 0 interceptions. Bill Davis led the team in rushing yards with 132 and 2 TDs. Darius Wade led the receivers with 19 receiving yards on 1 reception. Maurion Eleam led the defense in that game with 6 solo tackles and 0 assisted tackles while Caleb Kibodi led the defense in sacks with 1. Jalen Clark came away with the only interception for them in that one.

 

 

 

Missouri is entering this game with a 2-0 record overall and they have a 0-0 record in their conference games too. They are 2-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Kansas 42-31. Beau Pribula was the starting QB and he completed 30/39 passes for 334 passing yards, 3 touchdowns, and 0 interceptions. Jamal Roberts led the team in rushing yards with 143 and 1 TD. Kevin Coleman Jr. led the receivers with 126 receiving yards on 10 receptions and 1 TD. Daylan Carnell led the defense in that game with 4 solo tackles and 0 assisted tackles while Zion Young and Darris Smith each led the defense in sacks with 1. Daylan Carnell came away with the only interception for them in that one.

The current betting odds have Missouri listed as a 27.5 point favorite in this game according to Draftkings Sportsbook. Missouri has a 2-0 record overall this season and they have looked great in their 2 games. They demolished Central Arkansas in their season opener and now they are off a big win over a good Kansas team. They got themselves into an early hole in that one and the defense didn't look great throughout that game, but the offense looked great and they were able to dig themselves out of that early hole and end with a double digit win. Missouri has been building a great program under Drinkwitz over the last few seasons and they are going to be a dangerous team with that really good offense. Meanwhile, Louisiana has a 1-1 record overall this season and they haven't looked great in their games. They just beat a team from the FCS at home 34-10 in their last one, but the offense didn't look great in that game. They only put up 12 points at home in their season opening loss to Rice 14-12 too. Now this will be their first road game of the season against a much stronger SEC opponent and they just don't have the talent to keep up in this game. That Louisiana defense isn't stopping this Mizzou offense and as bad as that Missouri defense looked last week, Louisiana still doesn't have the offense to keep up with them and put up a fight. The best way to place a bet here is on Missouri to cover the spread in this game. 

Louisiana Missouri Prediction:  Our NCAAF Pick for Saturday, September 13, 2025 (4:00 pm ET start time) is Missouri 63 Louisiana 3.

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Louisiana Ragin' Cajuns: 19-29 ATS after allowing 14 points or less last game. 23-36 ATS after a game with a turnover margin of +2 or better. 6-3 OVER as an underdog. 12-4 OVER against SEC opponents. 

Missouri Tigers: 20-8 ATS in all lined games. 13-5 ATS as a favorite. 7-2 ATS after scoring 37 points or more last game. 9-5 OVER off a home win. 5-1 OVER after a 2 game home stand.

Louisiana Ragin' Cajuns:  W. Howard (QB) Out - Oblique.

Missouri Tigers:  B. Craig (K) Out - Undisclosed. S. Horn (QB) Out - Leg.

“I’m proud of our team. Last week, we got gut punched and it was certainly a game we expected so it’s a fine line you got to walk. I think our coaching staff did a phenomenal job of pushing them and our team responded.” - Michael Desormeaux after his team’s win against McNeese State in their last game. 

“I thought that was one of the coolest things: It wasn't our players folding in the moment that caused us to have issues, it was players making plays in the moment that elevated us.” - Eli Drinkwitz after his team’s win against Kansas in their last game. 

WR Sampson Jr., Shelton

WR Williams, Robert

WR Johnson, Jaydon

TE Jensen, Caden

QB Howard, Walker

RB Perry, Zylan

WR Johnson, Marquis

WR Manning, Joshua

WR Coleman Jr., Kevin

TE Norfleet, Brett

QB Pribula, Beau

RB Hardy, Ahmad

Passing: W. Howard (88)

Rushing: B. Davis (190)

Receiving: S. Sampson Jr. (63)

Touchdowns: B. Davis (2)

Passing: B. Pribula (617)

Rushing: A. Hardy (212)

Receiving: K. Coleman Jr. (174)

Touchdowns: B. Norfleet (3)

Coaches:

Louisiana Ragin' Cajuns: Michael Desormeaux (5th season)

Missouri Tigers: Eli Drinkwitz (6th season)