by Rod Pearson
Thursday, Sep 11, 2025
Game Time: 1:00 pm ET, Sunday, September 14, 2025
Venue: Nissan Stadium, Nashville, TN
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Rams -5.5, Titans +5.5; Over/Under: 41.5 points
Bet365: Point Spread: Rams -5.5, Titans +5.5; Over/Under: 41.5 points
BetMGM: Point Spread: Rams -5.5, Titans +5.5; Over/Under: 41.5 points
Season Record
Los Angeles Rams: 1-0 (3rd place, NFC West)
Tennessee Titans: 0-1 (3rd place, AFC South)
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Los Angeles Rams: won their last game at home against the Houston Texans 14-9.
Tennessee Titans: lost their last game on the road against the Denver Broncos 20-12.
Los Angeles Rams vs Tennessee Titans Preview and Analysis
The Rams are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Houston Texans 14-9. Matthew Stafford was the starting QB and he completed 21/29 passes for 245 passing yards, 1 touchdown, and 0 interceptions. Kyren Williams led the team in rushing yards with 66 and 1 TD. Puka Nacua led the receivers with 130 receiving yards on 10 receptions. Kamren Curl led the defense in that game with 8 solo tackles and 2 assisted tackles while Byron Young, Jaylen McCollough, and Tyler Davis each led the defense in sacks with 1. Cobie Durant came away with the only interception for them in that one.
The Titans are entering this game with a 0-1 record overall and they have a 0-0 record in their divisional games too. They are 0-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Denver Broncos 20-12. Cameron Ward was the starting QB and he completed 12/28 passes for 112 passing yards, 0 touchdowns, and 0 interceptions. Tony Pollard led the team in rushing yards with 60. Tony Pollard led the receivers with 29 receiving yards on 1 reception. Jarvis Brownlee Jr. led the defense in that game with 6 solo tackles and 3 assisted tackles while Jeffery Simmons led the defense in sacks with 1. Roger McCreary and Xavier Woods each came away with 1 interception for them in that one.
Rams vs Titans Prediction
The current betting odds have the Rams listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. The Rams have a 1-0 record overall this season and they didn't look great in week 1, but they found a way to get the win. They beat the Texans at home 14-9 and the offense looked terrible, but the defense was great and made the big plays at the end of the game for them to win. The offense didn't put up a ton of points, but they still moved the ball well in that one and played a lot better than the score suggests. Meanwhile, the Titans have a 0-1 record overall this season and they didn't look great in their season opener. They were on the road in Denver which isn't easy for a rookie QB making his NFL debut, and he showed it in that game. They lost 20-12 without scoring a touchdown in the game and Cam Ward didn't look good at all in the offense. The defense kept them in that game though, but they won't be able to do that here. The Broncos do have a great team with a lot of talent on offense, but they still have a 2nd year QB and he didn't have a great season opener. Now this defense will see a seasoned veteran in Matt Stafford and he has a lot more talent to work with in that Rams offense. The Rams will look better in this 2nd game and this is a bad situation for the Titans coming back home after a tough game in Denver. The best way to place a bet here is on the Rams to cover the spread in this game.
Rams Titans Prediction: Our NFL Pick for Sunday, September 14, 2025 (1:00 pm ET start time) is Rams 28 Titans 7.
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NFL Betting Trends
Los Angeles Rams: 22-14 ATS in all games. 12-6 ATS in road games. 11-6 ATS as a favorite. 11-5 ATS after playing a game at home. 11-6 UNDER as a favorite. 4-1 1H UNDER after scoring 14 points or less last game.
Tennessee Titans: 10-24 ATS in all games. 3-12 ATS as an underdog of 3.5 to 9.5 points. 4-10 ATS off a road loss. 9-5 UNDER off a road loss. 11-5 UNDER after playing their last game on the road.
Key Injuries
Los Angeles Rams: D. Adams (WR) Injured - NIR-Rest. R. Havenstein (OG) Injured - Ankle. C. Parkinson (TE) Injured - Shoulder. K. Dotson (OG) Injured - Ankle. S. Avila (OG) Injured - Ankle. D. Allen (TE) Injured - Knee.
Tennessee Titans: Q. Diggs (S) Injured - Hand. A. Key (LB) Injured - Pectoral. L. Sneed (CB) Injured - Knee. J. Latham (OT) Injured - Hip. T. Sweat (DL) Injured - Ankle. K. Winston Jr. (S) Injured - Hamstring. K. Mullings (RB) Injured - Ankle.
Notable Quotes
“I thought we did as many things as we (could possibly) do to not be able to put that game away, but what I do love about this group is they’re resilient. They keep responding. I thought we really found a way.” - Sean McVay after his team’s win against the Texans in their last game.
“Incredibly frustrating. Those are opportunities to score points and put the game away and we didn’t do it.” - Brian Callahan after his team’s loss against the Broncos in their last game.
Starting Lineups
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Atwell, Tutu
TE Higbee, Tyler
QB Stafford, Matthew
RB Williams, Kyren
Tennessee Titans
WR Ayomanor, Elic
WR Ridley, Calvin
WR Lockett, Tyler
TE Okonkwo, Chig
QB Ward, Cam
RB Pollard, Tony
Statistical Leaders
Los Angeles Rams
Passing: M. Stafford (245)
Rushing: K. Williams (66)
Receiving: P. Nacua (130)
Touchdowns: K. Williams (1)
Tennessee Titans
Passing: C. Ward (112)
Rushing: T. Pollard (60)
Receiving: T. Pollard (29)
Touchdowns: N/A
Coaches:
Los Angeles Rams: Sean McVay (9th season)
Tennessee Titans: Brian Callahan (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
