by Rod Pearson
Thursday, Sep 18, 2025
Game Time: 1:00 pm ET, Sunday, September 21, 2025
Venue: Lincoln Financial Field, Philadelphia, PA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Rams +3.5, Eagles -3.5; Over/Under: 44.5 points
Bet365: Point Spread: Rams +3.5, Eagles -3.5; Over/Under: 44.5 points
BetMGM: Point Spread: Rams +3.5, Eagles -3.5; Over/Under: 44.5 points
Season Record
Los Angeles Rams: 2-0 (3rd place, NFC West)
Philadelphia Eagles: 2-0 (1st place, NFC East)
Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the NFL on a 13-7 NFL RUN for +$5,470 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Los Angeles Rams: won their last game on the road against the Tennessee Titans 33-19.
Philadelphia Eagles: won their last game on the road against the Kansas City Chiefs 20-17.
Los Angeles Rams vs Philadelphia Eagles Preview and Analysis
The Rams are entering this game with a 2-0 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Tennessee Titans 33-19. Matthew Stafford was the starting QB and he completed 23/33 passes for 298 passing yards, 2 touchdowns, and 1 interception. Kyren Williams led the team in rushing yards with 66. Davante Adams led the receivers with 106 receiving yards on 6 receptions and 1 TD. Kamren Kinchens led the defense in that game with 7 solo tackles and 3 assisted tackles while Byron Young led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.
The Eagles are entering this game with a 2-0 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Kansas City Chiefs 20-17. Jalen Hurts was the starting QB and he completed 15/22 passes for 101 passing yards, 0 touchdowns, and 0 interceptions. Saquon Barkley led the team in rushing yards with 88 and 1 TD. DeVonta Smith led the receivers with 53 receiving yards on 4 receptions. Cooper DeJean led the defense in that game with 6 solo tackles and 1 assisted tackle while Moro Ojomo led the defense in sacks with 1. Andrew Mukuba came away with the only interception for them in that one.
Rams vs Eagles Prediction
The current betting odds have the Eagles listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The Eagles have looked great in their games this season with their 2-0 record overall and they have shown that they are still the team to beat in the NFL. They are off a tight win over the Chiefs in their last one and their offense struggled a lot against that defense, but they were moving the ball easily against the Cowboys so this offense will be fine with the talent they have. Meanwhile, the Rams have looked great in their games this season with their 2-0 record overall. They are off a 33-19 win over the Titans in their last one, but they struggled to pull away in that one as it was still a close game at halftime. They eventually broke it open in the 2nd half, but their offense still struggled at times and they had major problems in week 1 against a much better defense. The Eagles have the talent on defense to make this a really difficult game for that Rams offense with their slower start to the season. The Rams have been good defensively, but they did give up 19 points last week to one of the worst teams in the NFL, and this Eagles offense is due for a big game at home. They are going to have some momentum from that win at Arrowhead last week and they will carry that into this game too. The best way to place a bet here is on the Eagles to cover the spread in this game.
Rams Eagles Prediction: Our NFL Pick for Sunday, September 21, 2025 (1:00 pm ET start time) is Eagles 31 Rams 20.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Los Angeles Rams Philadelphia Eagles prediction, be sure to drop by every day for our weekly NFL predictions and previews.
NFL Betting Trends
Los Angeles Rams: 27-45 ATS against NFC East division opponents. 32-51 ATS on the road after playing their last game on the road. 8-4 OVER as an underdog of 3.5 to 9.5 points. 4-1 OVER after a win by 14 or more points.
Philadelphia Eagles: 8-2 ATS as a home favorite of 7 points or less. 9-4 ATS after a win by 6 or less points. 7-4 OVER off a road win. 3-0 OVER at home against NFC West division opponents.
Key Injuries
Los Angeles Rams: S. Avila (OG) Injured - Ankle. B. Fiske (DL) Injured - Oblique. D. Adams (WR) Injured - Rest. R. Havenstein (OG) Injured - Rest. C. Parkinson (TE) Injured - Shoulder.
Philadelphia Eagles: W. Shipley (RB) Injured - Oblique. J. Carter (DL) Injured - Shoulder. D. Goedert (TE) Injured - Knee. T. McKee (QB) Injured - Right Thumb.
Notable Quotes
“I was pleased with the way we finished that game. I thought we had really great command in the second half. That’s a really tough football team.” - Sean McVay after his team’s win against the Titans in their last game.
“Our job, especially early in the season, is find a way to win. Take pride in winning any way you possibly can. Work to get better throughout the week, and repeat. I think when you come off a season like we came off last year the expectation is that you're going to pick up where you left off. There are steps to this.” - Nick Sirianni after his team’s win against the Chiefs in their last game.
Starting Lineups
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Whittington, Jordan
TE Higbee, Tyler
QB Stafford, Matthew
RB Williams, Kyren
Philadelphia Eagles
WR Brown, A.J.
WR Dotson, Jahan
WR Smith, DeVonta
TE Calcaterra, Grant
QB Hurts, Jalen
RB Barkley, Saquon
Statistical Leaders
Los Angeles Rams
Passing: M. Stafford (543)
Rushing: K. Williams (132)
Receiving: P. Nacua (221)
Touchdowns: D. Allen (2)
Philadelphia Eagles
Passing: J. Hurts (253)
Rushing: S. Barkley (148)
Receiving: D. Smith (69)
Touchdowns: J. Hurts (3)
Coaches:
Los Angeles Rams: Sean McVay (9th season)
Philadelphia Eagles: Nick Sirianni (5th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
