by Rod Pearson
Tuesday, Oct 14, 2025
Game Time: 9:30 am ET, Sunday, October 19, 2025
Venue: Wembley Stadium, London, England
Where to Watch: NFL Network, NFL Network+
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Rams -3, Jaguars +3; Over/Under: 45.5 points
Bet365: Point Spread: Rams -3, Jaguars +3; Over/Under: 45 points
BetMGM: Point Spread: Rams -3, Jaguars +3; Over/Under: 45 points
Season Record
Los Angeles Rams: 4-2 (3rd place, NFC West)
Jacksonville Jaguars: 4-2 (2nd place, AFC North)
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Los Angeles Rams: won their last game on the road against the Baltimore Ravens 17-3.
Jacksonville Jaguars: lost their last game at home against the Seattle Seahawks 20-12.
Los Angeles Rams vs Jacksonville Jaguars Preview and Analysis
The Rams are entering this game with a 4-2 record overall and they have a 0-1 record in their divisional games too. They are 2-1 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Baltimore Ravens 17-3. Matthew Stafford was the starting QB and he completed 17/26 passes for 181 passing yards, 1 touchdown, and 0 interceptions. Kyren Williams led the team in rushing yards with 50 and 1 TD. Tyler Higbee led the receivers with 40 receiving yards on 4 receptions and 1 TD. Nate Landman led the defense in that game with 8 solo tackles and 9 assisted tackles while Byron Young led the defense in sacks with 2. Quentin Lake came away with the only interception for them in that one.
The Jaguars are entering this game with a 4-2 record overall and they have a 1-0 record in their divisional games too. They are 3-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Seattle Seahawks 20-12. Trevor Lawrence was the starting QB and he completed 27/42 passes for 258 passing yards, 2 touchdowns, and 0 interceptions. Travis Etienne Jr. led the team in rushing yards with 27. Brian Thomas Jr. led the receivers with 90 receiving yards on 8 receptions and 1 TD. Foyesade Oluokun led the defense in that game with 6 solo tackles and 3 assisted tackles while Arik Armstead led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Rams vs Jaguars Prediction
The current betting odds have the Rams listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Rams have looked really good in their games this season with their 4-2 record overall which has them right near the top of the NFC West in a really tight division race. The NFC West is wide open right now with 3 really good teams so the Rams will be looking to separate themselves in the coming weeks. They are off a 17-3 win over a banged up Ravens team, but their defense has looked really good all season and the offense has a ton of talent for Stafford to work with. Meanwhile, the Jaguars have also looked really good in their games this season with their 4-2 record overall which has them right near the top of the AFC South. They have been rolling in their games lately, but they did just lose their last one at home to the Seahawks 20-12. They have looked great all season, but they have also played against a lot of bad defenses. Their offense didn't look good at all against a better defense in Seattle and they are going to struggle against another good defense here. The Jags do have a really good defense themselves, but they came back down to Earth in the turnover battle their last game and they are going to start regressing after a hot start to the season. The Rams have the talent on defense to do what the Seahawks just did to this Jags offense, and the Jags defense isn't going to be ready for this Rams offense. The best way to place a bet here is on the Rams to cover the spread in this game.
Rams Jaguars Prediction: Our NFL Pick for Sunday, October 19, 2025 (9:30 am ET start time) is Rams 24 Jaguars 17.
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NFL Betting Trends
Los Angeles Rams: 16-35 ATS against teams with a turnover margin of +1 per game or better. 15-24 ATS on the road off a road win. 9-2 UNDER vs. poor passing defenses - allowing 235 or more passing yards/game. 9-1 UNDER versus poor defensive teams - allowing 5.65 yards/play or more.
Jacksonville Jaguars: 9-3 ATS when playing against a good team (Win Pct. 60% to 75%). 4-1 ATS at home vs. good passing teams averaging 7 or more passing yards/att. 13-4 UNDER in games where the line is +3 to -3. 8-4 UNDER when playing against a good team (Win Pct. 60% to 75%).
Key Injuries
Los Angeles Rams: R. Havenstein (OG) Injured - Ankle. C. Parkinson (TE) Injured - Concussion. T. Atwell (WR) Injured - Hamstring. P. Nacua (WR) Injured - Ankle. B. Corum (RB) Injured - Ankle. O. Speights (LB) Injured - Ankle. J. Stewart (LB) Injured - Illness.
Jacksonville Jaguars: E. Murray (S) Injured - Neck. Q. Morris (TE) Injured - Groin. D. Lloyd (LB) Injured - Calf. R. Hainsey (C) Injured - Hamstring. D. Brown (WR) Injured - Shoulder. T. Walker (DL) Injured - Wrist.
Notable Quotes
“I feel like we moved the ball up and down the field last week and had 400-something yards of offense and lost the game and felt pretty (bad) about it. Felt good about this one. Nice job getting a win.” - Matt Stafford after their win against the Ravens in their last game.
“It's an undisciplined operation at the moment. What's standing in our way? Right now, it's us.” - Liam Coen after his team’s loss against the Seahawks in their last game.
Starting Lineups
Los Angeles Rams
WR Adams, Davante
WR Mumpfield, Konata
WR Whittington, Jordan
TE Higbee, Tyler
QB Stafford, Matthew
RB Williams, Kyren
Jacksonville Jaguars
WR Thomas Jr., Brian
WR Brown, Dyami
WR Hunter, Travis
TE Long, Hunter
QB Lawrence, Trevor
RB Etienne Jr., Travis
Statistical Leaders
Los Angeles Rams
Passing: Matthew Stafford (1,684)
Rushing: Kyren Williams (418)
Receiving: Puka Nacua (616)
Touchdowns: Kyren Williams (5)
Jacksonville Jaguars
Passing: Trevor Lawrence (1,324)
Rushing: Travis Etienne Jr. (470)
Receiving: Brian Thomas Jr. (334)
Touchdowns: Travis Etienne Jr. (3)
Coaches:
Los Angeles Rams: Sean McVay (9th season)
Jacksonville Jaguars: Liam Coen (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
