by Rod Pearson
Friday, Sep 25, 2026
Game Time: 8:20 pm ET, Sunday, September 27, 2026
Venue: Empower Field at Mile High, Denver, CO
Where to Watch: NBC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Rams -2.5, Broncos +2.5; Over/Under: 43.5 points
Bet365: Point Spread: Rams -2.5, Broncos +2.5; Over/Under: 43.5 points
BetMGM: Point Spread: Rams -2, Broncos +2; Over/Under: 44 points
Season Record
Los Angeles Rams: 1-1 (3rd place, NFC West)
Denver Broncos: 1-1 (2nd place, AFC West)
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Recent Form
Los Angeles Rams: won their last game at home against the New York Giants 28-6.
Denver Broncos: won their last game at home against the Jacksonville Jaguars 20-13.
Los Angeles Rams vs Denver Broncos Preview and Analysis
The Rams are entering this game with a 1-1 record overall and they have a 0-1 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New York Giants 28-6. Matthew Stafford was the starting QB and he completed 22/31 passes for 327 passing yards, 4 touchdowns, and 1 interception. Kyren Williams led the team in rushing yards with 85. Davante Adams led the receivers with 195 receiving yards on 8 receptions and 2 TDs. Quentin Lake and Nate Landman each led the defense in that game with 7 solo tackles while Byron Young and Wesley Bailey each led the defense in sacks with 1. Trent McDuffie came away with the only interception for them in that one.
The Broncos are entering this game with a 1-1 record overall and they have a 0-1 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Jacksonville Jaguars 20-13. Bo Nix was the starting QB and he completed 22/31 passes for 288 passing yards, 1 touchdown, and 1 interception. Jonah Coleman led the team in rushing yards with 39 and 1 TD. Jaylen Waddle led the receivers with 138 receiving yards on 8 receptions. Alex Singleton led the defense in that game with 9 solo tackles while Malcolm Roach and Quandarrius Robinson each led the defense in sacks with 1. Riley Moss came away with the only interception for them in that one.
Rams vs Broncos Prediction
The current betting odds have the Rams listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. The Rams haven't looked great in their games this season with their 1-1 record overall so far. They haven't played any road games yet and will be playing their 1st road game of the season here. Meanwhile, the Broncos haven't looked great in their games this season with their 1-1 record overall so far. They have looked better on their home field though with their 1-0 home record this season. The Broncos are coming off a 20-13 win over the Jags in their last one and they looked a lot better in that game. They had one of the best defenses in the NFL last season and that defense looked a lot better against the Jaguars after a terrible week 1. They did lose their season opener to the Chiefs 31-10 though and as good as their defense looked last week, the offense still didn't look great. They had a lot of trouble putting points up against the Jaguars and they were even down 10-3 at half before coming back in the 2nd half. The offense hasn't looked good in both games though and Bo Nix was really up and down all season last year. The Rams are in a similar boat as they looked terrible in week 1, losing 27-7 to the 49ers, but that game was also in Australia. They looked a lot better last week in their 28-6 win over the Giants and the offense found a lot of momentum in that one. The Rams looked like the team that was the Super Bowl favorite entering the season and they weren't even fully healthy either. The Broncos have a great defense that can cause trouble for Stafford here, but the Rams also have a great defense themselves along with a more consistent offense to get the job done. The best way to place a bet here is on the Rams to cover the spread in this game.
Rams Broncos Prediction: Our NFL Pick for Sunday, September 27, 2026 (8:20 pm ET start time) is Rams 24 Broncos 17.
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NFL Betting Trends
Los Angeles Rams: 6-12 ATS on the road against AFC West division opponents. 21-36 ATS on the road in September games. 16-10 UNDER as a favorite. 7-3 UNDER in non-conference games.
Denver Broncos: 14-6 ATS in home games. 8-3 ATS in a home game where the total is between 42.5 and 49 points. 8-2 ATS in non-conference games. 11-6 UNDER as an underdog. 13-6 UNDER in all games where the total is between 42.5 and 49 points.
Key Injuries
Los Angeles Rams: A. Jackson (OG) Injured - Knee. T. Ferguson (TE) Injured - Ankle. N. Landman (LB) Injured - Shoulder. C. Parkinson (TE) Injured - Knee. K. Kinchens (S) Injured - Hamstring. P. Nacua (WR) Injured - Hip. J. Whittington (WR) Injured - Quadricep.
Denver Broncos: R. Harvey (RB) Injured - Hamstring. M. Mims Jr. (WR) Injured - Foot. J. Coleman (RB) Injured - Ankle. J. Dobbins (RB) Injured - Hip.
Notable Quotes
“(Adams) was special, and it showed all night. I thought he made some great plays, but you can see there's a lot of trust he and Matthew have. It's only going to continue to build, and I was really happy for him.” - Sean McVay after his team’s win against the Giants in their last game.
“I’m glad he’s ours.” - Sean Payton on Jaylen Waddle after his team’s win against the Jaguars in their last game.
Starting Lineups
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Whittington, Jordan
TE Parkinson, Colby
QB Stafford, Matthew
RB Williams, Kyren
Denver Broncos
WR Sutton, Courtland
WR Waddle, Jaylen
WR Bryant, Pat
TE Engram, Evan
QB Nix, Bo
RB Dobbins, J.K.
Statistical Leaders
Los Angeles Rams
Passing: Matthew Stafford (482)
Rushing: Blake Corum (133)
Receiving: Davante Adams (221)
Touchdowns: Kyren Williams (2)
Denver Broncos
Passing: Bo Nix (419)
Rushing: J.K. Dobbins (72)
Receiving: Jaylen Waddle (140)
Touchdowns: Evan Engram (1)
Coaches:
Los Angeles Rams: Sean McVay (10th season)
Denver Broncos: Sean Payton (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
