by Rod Pearson
Friday, Aug 22, 2025
Game Time: 8:40 pm ET, Saturday, August 23, 2025
Venue: Petco Park, San Diego, CA
Where to Watch: Fox Sports 1
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Dodgers -144, Padres +118; Over/Under: 8.5 runs
Bet365: Moneyline odds: Dodgers -140, Padres +120; Over/Under: 8 runs
BetMGM: Moneyline odds: Dodgers -140, Padres +115; Over/Under: 8 runs
Season Record
Los Angeles Dodgers: 73-55 (1st place, NL West)
San Diego Padres: 72-56 (2nd place, NL West)
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Recent Form
Los Angeles Dodgers: 5-5 last 10
San Diego Padres: 6-4 last 10
Los Angeles Dodgers vs San Diego Padres Preview and Analysis
The Dodgers are entering this series off a win and split their 4-game series against the Colorado Rockies 2-2 in their last series. They enter this game with a 73-55 record overall and have a road record of 32-31. This is the 2nd game of a 3-game series with the Padres on Saturday with the series opener still to be played on Friday. Their offense ranks 2nd in the MLB with a .773 OPS. Blake Snell is their starting pitcher on Friday while Tyler Glasnow is making his start in this game on Saturday. He is 1-1 with a 3.12 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 1 HR, and 1 BB with 8 SO on 6 hits through 5 IP against the San Diego Padres.
The Padres are entering this series off a win and won their 4-game series against the San Francisco Giants 3-1 in their last series. They enter this game with a 72-56 record overall and have a home record of 41-21. This is the 2nd game of a 3-game series with the Dodgers on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 20th in the MLB with a .707 OPS. Yu Darvish is their starting pitcher on Friday while Nestor Cortes is making his start in this game on Saturday. He is 1-2 with a 5.87 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 3 homers, and 4 walks with 5 strikeouts on 7 hits through 5.2 innings pitched against the San Francisco Giants.
Dodgers vs Padres Prediction
The current betting odds have the Dodgers listed as a favorite in this game according to Draftkings Sportsbook. The Dodgers have looked great in their games this season with their 72-55 record overall which has them right at the top of the NL West. They haven't been a great road team though with their 31-31 road record this season. Meanwhile, the Padres have looked really good in their games this season with their 71-56 record overall which has them right near the top of the NL West. They have looked great in their own ballpark too with their 40-21 home record this season. The Padres have looked really good lately too, but the Dodgers do have the better pitching matchup here and the Padres haven't had a ton of success against the Dodgers this season. The Dodgers are going with Glasnow in this one and he has looked good this season. He is 1-1 with a 3.12 ERA and hasn't been giving up many runs lately. His team has lost 2 of their last 3 games with him starting, but he is coming off a good start in which he only gave up 2 earned runs and the Padres don't have a great offense this season either. Cortes is on the mound for the Padres in this one and he hasn't looked good this season either. He is 1-2 with a 5.87 ERA and has been giving up quite a few runs in his starts. His team has won 3 of their last 4 games with him starting, but he did give up 4 earned runs in his last start which has been a common theme for him and the Dodgers do have one of the best offenses in the MLB, putting up more runs lately too. The best way to place a bet here is on the Dodgers to win this game.
Dodgers Padres Prediction: Our MLB Pick for Saturday, August 23, 2025 (8:40 pm ET start time) is Dodgers 7 Padres 2.
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MLB Betting Trends
Los Angeles Dodgers: 282-189 (-9.1 units) on the moneyline in all games. 130-104 (-8.1 units) on the moneyline in road games. 126-103 (-11 units) on the moneyline when playing against a team with a winning record. 25-15 UNDER on the road vs. a starting pitcher whose lasts less than 5 innings per start.
San Diego Padres: 72-77 (+15 units) on the moneyline as an underdog of +100 or higher. 252-208 (+4.1 units) on the moneyline in all games. 87-75 (+17.6 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 38-18 UNDER vs. an NL starting pitcher whose ERA is 3.20 or better.
Key Injuries
Los Angeles Dodgers: S. Ohtani (DH) Day To Day - Leg. M. Muncy (3B) Ten Day IL - Oblique. B. Stewart (RP) Fifteen Day IL - Shoulder. T. Edman (2B) Ten Day IL - Ankle. K. Yates (RP) Fifteen Day IL - Back. H. Kim (2B) Ten Day IL - Shoulder. T. Scott (RP) Fifteen Day IL - Elbow. M. Kopech (RP) Sixty Day IL - Knee. E. Hernandez (1B) Ten Day IL - Elbow. R. Sasaki (SP) Sixty Day IL - Shoulder. T. Gonsolin (SP) Sixty Day IL - Elbow. E. Phillips (RP) Sixty Day IL - forearm. K. Hurt (SP) Sixty Day IL - Elbow. B. Graterol (RP) Sixty Day IL - Shoulder. M. Grove (RP) Sixty Day IL - Shoulder. R. Ryan (SP) Sixty Day IL - Elbow. G. Stone (SP) Sixty Day IL - Shoulder.
San Diego Padres: J. Merrill (CF) Day To Day - Ankle. M. King (SP) Fifteen Day IL - Knee. J. Brito (RP) Sixty Day IL - Forearm. J. Musgrove (SP) Sixty Day IL - Elbow.
Notable Quotes
“I wish we’d have won all four. It just didn’t happen. They beat us two games pretty handily. That’s just the way baseball is. We’ve got to go out there and, regardless of the standings, we’ve got to beat [the Padres].” - Dave Roberts after his team’s win against the Rockies in their game on Thursday.
“Listen, we’re excited, we are human. We are aware of how we didn’t put absolutely our best foot forward. We competed well, just couldn’t get on the good side of it. Ultimately, it’s about execution and playing the game. Really excited, can’t wait for tomorrow night. I wish it was tonight.” - Mike Shildt after his team’s win against the Giants in their game on Thursday.
Starting Lineups
Los Angeles Dodgers
Mookie Betts (R) SS
Freddie Freeman (L) 1B
Will Smith (R) DH
Michael Conforto (L) LF
Alex Freeland (S) 3B
Dalton Rushing (L) C
Andy Pages (R) CF
Alex Call (R) RF
Miguel Rojas (R) 2B
San Diego Padres
Fernando Tatis Jr. (R) RF
Luis Arraez (L) 1B
Manny Machado (R) 3B
Ryan O'Hearn (L) DH
Xander Bogaerts (R) SS
Gavin Sheets (L) LF
Ramón Laureano (R) CF
Jake Cronenworth (L) 2B
Freddy Fermin (R) C
Statistical Leaders
Los Angeles Dodgers
Batting Average: Hyeseong Kim (.304)
Hits: Shohei Ohtani (138)
Home Runs: Shohei Ohtani (44)
RBI: Shohei Ohtani (83)
Stolen Bases: Shohei Ohtani (17)
Wins: Yoshinobu Yamamoto (10)
Saves: Tanner Scott (19)
ERA: Evan Phillips (0.00)
San Diego Padres
Batting Average: Ramón Laureano (.333)
Hits: Manny Machado (145)
Home Runs: Manny Machado (21)
RBI: Manny Machado (77)
Stolen Bases: Fernando Tatis (25)
Wins: Nick Pivetta (13)
Saves: Robert Suarez (33)
ERA: Bradgley Rodriguez (0.00)
Managers:
Los Angeles Dodgers: Dave Roberts (10th season)
San Diego Padres: Mike Shildt (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
