Los Angeles Dodgers vs San Diego Padres Prediction, Preview and Odds - 08/22/2025

Game Time: 9:40 pm ET, Friday, August 22, 2025

Venue:  Petco Park, San Diego, CA 

Where to Watch:  MLB.tv, Sportsnet LA, PADRES.tv 

DraftKings:  Moneyline odds:  Dodgers -125, Padres +105; Over/Under:  8 runs

Bet365:  Moneyline odds:  Dodgers -125, Padres +105; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Dodgers -125, Padres +105; Over/Under:  7.5 runs

Los Angeles Dodgers:  72-55 (1st place, NL West)

San Diego Padres:  71-56 (2nd place, NL West)

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Los Angeles Dodgers:  4-6 last 10

San Diego Padres:  6-4 last 10

The Dodgers completed the sweep in their 3-game series against the San Diego Padres 3-0. They enter this game with a 72-55 record overall and have a road record of 31-31. This is the series opener of a 3-game series with the Padres on Friday with the series finale of their series against the Colorado Rockies still to be played on Thursday. The Dodgers lost the series opener of that series on Monday, won the 2nd game on Tuesday, and lost the 3rd game on Wednesday. Their offense ranks 2nd in the MLB with a .771 OPS. Clayton Kershaw is their starting pitcher on Thursday while Blake Snell is making his start in this game on Friday. He is 3-1 with a 1.80 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 2 BB with 3 SO on 5 hits through 6 IP against the San Diego Padres.

The Padres got swept in their 3-game series against the Los Angeles Dodgers 3-0. They enter this game with a 71-56 record overall and have a home record of 40-21. This is the 1st game of a 3-game series with the Dodgers on Friday with the series finale of their series against the San Francisco Giants still to be played on Thursday. The Padres lost the 1st game of that series on Monday, won the 2nd game on Tuesday, and won the 3rd game on Wednesday. Their offense ranks 20th in the MLB with a .707 OPS. Dylan Cease is their starting pitcher on Thursday while Yu Darvish is making his start in this game on Friday. He is 2-3 with a 5.97 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 2 homers, and 2 walks with 5 strikeouts on 3 hits through 4 innings pitched against the Los Angeles Dodgers.

The current betting odds have the Dodgers listed as a slight favorite in this game according to Draftkings Sportsbook. The Dodgers have looked great in their games this season with their 72-55 record overall which has them right at the top of the NL West. They haven't been a great road team though with their 31-31 road record this season. Meanwhile, the Padres have looked really good in their games this season with their 71-56 record overall which has them right near the top of the NL West. They have looked great in their own ballpark too with their 40-21 home record this season. The Padres have also looked like the hotter team lately as they are 6-4 in their last 10 games while the Dodgers are 4-6 and coming off a bad series against the Rockies where the best they can do is split the series. The Dodgers did sweep the Padres less than a week ago though and they also have the better pitching matchup so they can take advantage of that here. The Padres are going with Darvish in this one and he hasn't looked great this season. He is 2-3 with a 5.97 ERA and even though the team has been having success with him lately, he has still been giving up a lot of runs. The team has won 3 of their last 4 games with him starting now, but he did give up 4 earned runs in his last start which was against the Dodgers and the Dodgers have the much stronger offense to help out in this game too. The Dodgers are going with Snell in this one and he has looked good this season. He is 3-1 with a 1.80 ERA and hasn't been giving up many runs at all. He is coming off another great start in which he gave up no runs against the Padres and the team has had a lot of success with him too, winning 4 of their last 5 games with him starting. The Dodgers always bring their best effort for the Padres so this is a good series for them to get back on track. The best way to place a bet here is on the Dodgers to win this game. 

Dodgers Padres Prediction:  Our MLB Pick for Friday, August 22, 2025 (9:40 pm ET start time) is Dodgers 6 Padres 3.

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Los Angeles Dodgers: 281-189 (-10.1 units) on the moneyline in all games. 129-104 (-9.1 units) on the moneyline in road games. 126-103 (-11 units) on the moneyline when playing against a team with a winning record. 21-14 UNDER vs. an NL starting pitcher whose ERA is 5.40 or worse.

San Diego Padres: 72-77 (+15 units) on the moneyline as an underdog of +100 or higher. 77-59 (+7.1 units) on the moneyline against left-handed starters. 87-75 (+17.6 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 84-49 UNDER against left-handed starters.

Los Angeles Dodgers:  S. Ohtani (DH) Day To Day - Leg. M. Muncy (3B) Ten Day IL - Oblique. B. Stewart (RP) Fifteen Day IL - Shoulder. T. Edman (2B) Ten Day IL - Ankle. K. Yates (RP) Fifteen Day IL - Back. H. Kim (2B) Ten Day IL - Shoulder. T. Scott (RP) Fifteen Day IL - Elbow. M. Kopech (RP) Sixty Day IL - Knee. E. Hernandez (1B) Ten Day IL - Elbow. R. Sasaki (SP) Sixty Day IL - Shoulder. T. Gonsolin (SP) Sixty Day IL - Elbow. E. Phillips (RP) Sixty Day IL - forearm. K. Hurt (SP) Sixty Day IL - Elbow. B. Graterol (RP) Sixty Day IL - Shoulder. M. Grove (RP) Sixty Day IL - Shoulder. R. Ryan (SP) Sixty Day IL - Elbow. G. Stone (SP) Sixty Day IL - Shoulder.

San Diego Padres:  J. Merrill (CF) Day To Day - Ankle. M. King (SP) Fifteen Day IL - Knee. J. Brito (RP) Sixty Day IL - Forearm. J. Musgrove (SP) Sixty Day IL - Elbow.

“It was getting stiff and there was some swelling in there. It was in the thigh, fortunately, and not off the knee. But it got him square. I felt as the game was going to go on, it was going to stiffen up more.” - Dave Roberts on taking Ohtani out of the game after his team’s loss against the Rockies in their game on Wednesday.

“It really is an art form. It’s timing as much as anything. And then it’s just the athleticism.” - Mike Shildt after his team’s win against the Giants in their game on Wednesday.

Mookie Betts (R) SS

Freddie Freeman (L) 1B

Will Smith (R) DH

Michael Conforto (L) LF

Alex Freeland (S) 3B

Dalton Rushing (L) C

Andy Pages (R) CF

Alex Call (R) RF

Miguel Rojas (R) 2B

Fernando Tatis Jr. (R) RF

Luis Arraez (L) DH

Manny Machado (R) 3B

Ryan O'Hearn (L) 1B

Ramón Laureano (R) CF

Gavin Sheets (L) LF

Jose Iglesias (R) SS

Jake Cronenworth (L) 2B

Freddy Fermin (R) C

Batting Average:  Hyeseong Kim (.304)

Hits:  Shohei Ohtani (138)

Home Runs:  Shohei Ohtani (44)

RBI:  Shohei Ohtani (83)

Stolen Bases:  Shohei Ohtani (17)

Wins:  Yoshinobu Yamamoto (10)

Saves:  Tanner Scott (19)

ERA:  Evan Phillips (0.00)

Batting Average:  Ramón Laureano (.324)

Hits:  Manny Machado (143)

Home Runs:  Manny Machado (21)

RBI:  Manny Machado (74)

Stolen Bases:  Fernando Tatis (25)

Wins:  Nick Pivetta (13)

Saves:  Robert Suarez (33)

ERA:  Bradgley Rodriguez (0.00)

Managers:

Los Angeles Dodgers: Dave Roberts (10th season)

San Diego Padres: Mike Shildt (2nd season)