Los Angeles Dodgers vs San Diego Padres Prediction, Preview and Odds - 06/26/2026

Game Time: 9:45 pm ET, Friday, June 26, 2026

Venue:  Petco Park, San Diego, CA

Where to Watch:  Apple TV

DraftKings:  Moneyline odds:  Dodgers -157, Padres +130; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Dodgers -155, Padres +130; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Dodgers -155, Padres +125; Over/Under:  7.5 runs

Los Angeles Dodgers:  52-29 (1st place, NL West)

San Diego Padres:  42-37 (2nd place, NL West)

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Los Angeles Dodgers:  7-3 last 10

San Diego Padres:  6-4 last 10

The Dodgers are entering this series off a win and completed the sweep in their 3-game series against the Minnesota Twins 3-0 in their last series. They enter this game with a 52-29 record overall and have a road record of 26-15. This is the series opener of a 3-game series with the Padres on Friday and they have Thursday off as a day of rest. Their offense ranks 1st in the MLB with a .783 OPS. Shohei Ohtani was their starting pitcher on Wednesday while Roki Sasaki is making his start in this game on Friday. He is 3-4 with a 4.76 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 2 HR, and 1 BB with 6 SO on 4 hits through 5.2 IP against the Baltimore Orioles.

The Padres are entering this series off a win and completed the sweep in their 3-game series against the Atlanta Braves 3-0 in their last series. They enter this game with a 42-37 record overall and have a home record of 22-19. This is the 1st game of a 3-game series with the Dodgers on Friday and they have Thursday off as a day of rest. Their offense ranks 30th in the MLB with a .658 OPS. JP Sears was their starting pitcher on Wednesday while Walker Buehler is making his start in this game on Friday. He is 4-3 with a 3.96 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 7 strikeouts on 5 hits through 5.1 innings pitched against the Texas Rangers.

The current betting odds have the Padres listed as an underdog in this game according to Draftkings Sportsbook. The Padres have looked good in their games this season with their 42-37 record overall which has them right near the top of the NL West. They have looked good in their own ballpark too with their 22-19 home record this season. Meanwhile, the Dodgers have looked great in their games this season with their 52-29 record overall which has them right at the top of the NL West with one of the best records in MLB. They have been a great road team too with their 26-15 road record this year. The Dodgers are 7-3 in their last 10 games and they have looked great lately, but the Padres have also been getting hot now too. The Padres are 6-4 in their last 10 games and they just swept the Braves in their last series. They are going with Buehler in this one and he hasn't looked bad this season. He is 4-3 with a 3.96 ERA and his team has been having a lot of success with him lately. They have won 3 games in a row now with him starting and he is coming off another great start in which he gave up 1 earned run. That is starting to become a common theme for him lately and he will be looking to have a great performance against his former team. The Dodgers are going with Sasaki in this one and he hasn't looked great this season. He is 3-4 with a 4.76 ERA and he has been giving up quite a few runs all year. The team has won 2 of their last 3 games with him starting, but he did give up 3 earned runs in his last start and he has had some really bad starts this year. The Dodgers have the edge with their offense, but the Padres have the edge with their pitching staff and this is a pitching matchup that the Padres can take advantage of. The best way to place a bet here is on the Padres to win this game. 

Dodgers Padres Prediction:  Our MLB Pick for Friday, June 26, 2026 (9:45 pm ET start time) is Padres 5 Dodgers 3.

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Los Angeles Dodgers: 267-171 (-10.3 units) on the moneyline in all games. 240-138 (-6.8 units) on the moneyline as a favorite of -110 or higher. 185-122 (-12.2 units) on the moneyline against right-handed starters. 11-2 UNDER when the total is 7 to 7.5.

San Diego Padres: 231-183 (+26.2 units) on the moneyline in all games. 122-85 (+9.6 units) on the moneyline in home games. 86-81 (+27.8 units) on the moneyline as an underdog of +100 or higher. 9-5 UNDER as a home underdog of +100 or higher.

Los Angeles Dodgers:  K. Tucker (RF) Day To Day - Back. B. Treinen (RP) Fifteen Day IL - Elbow. W. Smith (C) Ten Day IL - Neck. B. Graterol (RP) Sixty Day IL - Shoulder. T. Hernandez (LF) Ten Day IL - Hamstring. B. Snell (SP) Sixty Day IL - Elbow. E. Hernandez (1B) Ten Day IL - Oblique. B. Casparius (RP) Sixty Day IL - Shoulder. E. Diaz (RP) Sixty Day IL - Elbow. T. Glasnow (SP) Sixty Day IL - Back. L. Knack (SP) Sixty Day IL - Chest. J. Cousins (RP) Sixty Day IL - Elbow. G. Stone (SP) Sixty Day IL - Shoulder. B. Miller (SP) Sixty Day IL - Shoulder. E. Phillips (RP) Sixty Day IL - Elbow.

San Diego Padres:  L. Giolito (SP) Fifteen Day IL - Elbow. J. Estrada (RP) Fifteen Day IL - Knee. R. Laureano (LF) Sixty Day IL - Hip. N. Pivetta (SP) Sixty Day IL - Elbow. L. Campusano (C) Ten Day IL - Toe. M. Waldron (SP) Fifteen Day IL - Arm. J. Cronenworth (2B) Seven Day IL - Concussion. G. Marquez (SP) Fifteen Day IL - Forearm. B. Hoeing (RP) Sixty Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

"I don't think it was a blow [to his ego]. I actually think it freed [Rushing] up. I think that if there's ever any doubt, the pitcher always has the right of last refusal and can call his own game. So I think once we decided to do that, then it was pretty clean after that." - Dave Roberts on Shohei Ohtani taking over the pitch-calling duties in his team’s win against the Twins in their game on Wednesday. 

“The way he threw the ball today is what he’s capable of doing in the big leagues. We needed him big. He stepped up.” - Craig Stammen after his team’s win against the Braves in their game on Wednesday. 

Shohei Ohtani (L) P

Andy Pages (R) CF

Freddie Freeman (L) 1B

Mookie Betts (R) SS

Max Muncy (L) 3B

Alex Call (R) RF

Ryan Ward (L) LF

Dalton Rushing (L) C

Alex Freeland (S) 2B

Fernando Tatis Jr. (R) 2B

Samad Taylor (R) LF

Manny Machado (R) 3B

Xander Bogaerts (R) SS

Jackson Merrill (L) CF

Miguel Andujar (R) DH

Ty France (R) 1B

Freddy Fermin (R) C

Jase Bowen (R) RF

Batting Average:  Enrique Hernández (1.000)

Hits:  Andy Pages (83)

Home Runs:  Shohei Ohtani (17)

RBI:  Andy Pages (58)

Stolen Bases:  Andy Pages (8)

Wins:  Justin Wrobleski (9)

Saves:  Tanner Scott (11)

ERA:  Charlie Barnes (0.00)

Batting Average:  Samad Taylor (.379)

Hits:  Fernando Tatis (85)

Home Runs:  Manny Machado (14)

RBI:  Manny Machado (43)

Stolen Bases:  Fernando Tatis (19)

Wins:  Randy Vásquez (6)

Saves:  Mason Miller (21)

ERA:  Mason Miller (0.79)

Managers:

Los Angeles Dodgers: Dave Roberts (11th season)

San Diego Padres: Craig Stammen (1st season)