by Rod Pearson
Tuesday, Sep 23, 2025
Game Time: 1:00 pm ET, Sunday, September 28, 2025
Venue: MetLife Stadium, East Rutherford, NJ
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chargers -6.5, Giants +6.5; Over/Under: 43.5 points
Bet365: Point Spread: Chargers -6.5, Giants +6.5; Over/Under: 44 points
BetMGM: Point Spread: Chargers -6.5, Giants +6.5; Over/Under: 44.5 points
Season Record
Los Angeles Chargers: 3-0 (1st place, AFC West)
New York Giants: 0-3 (4th place, NFC East)
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Recent Form
Los Angeles Chargers: won their last game at home against the Denver Broncos 23-20.
New York Giants: lost their last game at home against the Kansas City Chiefs 22-9.
Los Angeles Chargers vs New York Giants Preview and Analysis
The Chargers are entering this game with a 3-0 record overall and they have a 3-0 record in their divisional games too. They are 1-0 in their home games, 1-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Denver Broncos 23-20. Justin Herbert was the starting QB and he completed 28/47 passes for 300 passing yards, 1 touchdown, and 1 interception. Omarion Hampton led the team in rushing yards with 70 and 1 TD. Quentin Johnston led the receivers with 89 receiving yards on 6 receptions. Derwin James Jr. led the defense in that game with 10 solo tackles and 2 assisted tackles while Derwin James Jr. and Troy Dye each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Giants are entering this game with a 0-3 record overall and they have a 0-2 record in their divisional games too. They are 0-1 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Kansas City Chiefs 22-9. Russell Wilson was the starting QB and he completed 18/32 passes for 160 passing yards, 0 touchdowns, and 2 interceptions. Cameron Skattebo led the team in rushing yards with 60 and 1 TD. Cameron Skattebo led the receivers with 61 receiving yards on 6 receptions. Paulson Adebo led the defense in that game with 6 solo tackles and 1 assisted tackle while Brian Burns led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Chargers vs Giants Prediction
The current betting odds have the Chargers listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Chargers have looked great in their games this season with their 3-0 record overall which has them right at the top of the AFC West and looking like one of the best teams in the NFL this season. Their defense has looked great in their games with one of the best defenses in the NFL, and their offense has now taken a big step with Harbaugh in his 2nd year coaching there. Meanwhile, the Giants have looked terrible in their games this season with their 0-3 record overall which has them right at the bottom of the NFC East already. Their defense hasn't been terrible, but it definitely hasn't been great either and it doesn't help that their offense can't stay on the field. Their offense had 1 good game against a terrible Cowboys defense, but they struggled against the Commanders and the Chiefs. Now they are moving on from Russell Wilson already so Dart is going to be making his NFL debut here, but this isn't exactly a soft landing spot for a rookie QB making his debut. They are going to be at home, but that is the only going for them as his 1st start is going to be against one of the best defenses in the NFL. This is a terrible situation for the Giants to be starting Dart in and their offense isn't going to look any better with him at QB against this kind of defense. The Chargers are rolling right now and the Giants just won't be able to keep up. The best way to place a bet here is on the Chargers to cover the spread in this game.
Chargers Giants Prediction: Our NFL Pick for Sunday, September 28, 2025 (1:00 pm ET start time) is Chargers 31 Giants 7.
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NFL Betting Trends
Los Angeles Chargers: 8-1 ATS as a favorite of 3.5 to 9.5 points. 5-0 ATS when playing against a terrible team (Win Pct. <=25%). 5-0 ATS vs. poor teams - outscored by 6+ points per game on the season. 12-6 UNDER in road games. 7-1 UNDER in a road game where the total is between 42.5 and 49 points.
New York Giants: 13-22 ATS in all games. 5-11 ATS in all games where the total is between 42.5 and 49 points. 2-10 ATS off a home loss. 24-13 UNDER in all games. 13-4 UNDER as a home underdog of 7 points or less. 12-5 UNDER in all games where the total is between 42.5 and 49 points.
Key Injuries
Los Angeles Chargers: R. Lovato (LS) Injured - NIR-Personal. B. Bozeman (C) Injured - Back. D. Hand (DL) Injured - Back. D. Jackson (CB) Injured - Ankle. W. Dissly (TE) Injured - Knee. M. Becton (OG) Injured - Concussion. E. Molden (CB) Injured - Hamstring. D. Davis (WR) Injured - Knee. T. Pipkins III (OT) Injured - Knee. C. Hart (CB) Injured - Hip.
New York Giants: R. Nunez-Roches Sr. (DL) Injured - Foot. T. Tracy Jr. (RB) Injured - Shoulder. D. Flannigan-Fowles (LB) Injured - Calf. C. Golston (DL) Injured - Ankle. A. Green (CB) Injured - Hip. D. Muasau (LB) Injured - Concussion. J. Schmitz Jr. (C) Injured - Neck. D. Slayton (WR) Injured - Calf. A. Thomas (OT) Injured - Foot. G. Gano (K) Injured - Groin. T. Johnson (TE) Injured - Toe. M. Nabers (WR) Injured - Shoulder.
Notable Quotes
“I don’t think I have the vocabulary to express how great I feel. It’s a signature win. It’s one that reveals your character. That all-out hustle from our guys from the first snap of the game to the end.” - Jim Harbaugh after his team’s win against the Broncos in their last game.
“When you don’t convert on third down, it’s hard to sustain anything. On offense, nothing was good enough. I would be booing too.” - Brian Daboll after his team’s loss against the Chiefs in their last game.
Starting Lineups
Los Angeles Chargers
WR Johnston, Quentin
WR Allen, Keenan
WR McConkey, Ladd
TE Conklin, Tyler
QB Herbert, Justin
RB Hampton, Omarion
FB Matlock, Scott
New York Giants
WR Nabers, Malik
WR Slayton, Darius
WR Robinson, Wan'Dale
TE Johnson, Theo
QB Dart, Jaxson
RB Skattebo, Cam
Statistical Leaders
Los Angeles Chargers
Passing: Justin Herbert (860)
Rushing: Omarion Hampton (142)
Receiving: Quentin Johnston (239)
Touchdowns: Quentin Johnston (3)
New York Giants
Passing: Russell Wilson (778)
Rushing: Cam Skattebo (102)
Receiving: Malik Nabers (251)
Touchdowns: Malik Nabers (2)
Coaches:
Los Angeles Chargers: Jim Harbaugh (2nd season)
New York Giants: Brian Daboll (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
