by Rod Pearson
Friday, Sep 12, 2025
Game Time: 10:00 pm ET, Monday, September 15, 2025
Venue: Allegiant Stadium, Las Vegas, NV
Where to Watch: ESPN
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chargers -3.5, Raiders +3.5; Over/Under: 46.5 points
Bet365: Point Spread: Chargers -3.5, Raiders +3.5; Over/Under: 46.5 points
BetMGM: Point Spread: Chargers -3.5, Raiders +3.5; Over/Under: 46.5 points
Season Record
Los Angeles Chargers: 1-0 (1st place, AFC West)
Las Vegas Raiders: 1-0 (3rd place, AFC West)
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Recent Form
Los Angeles Chargers: won their last game at a neutral site against the Kansas City Chiefs 27-21.
Las Vegas Raiders: won their last game on the road against the New England Patriots 20-13.
Los Angeles Chargers vs Las Vegas Raiders Preview and Analysis
The Chargers are entering this game with a 1-0 record overall and they have a 1-0 record in their divisional games too. They are 0-0 in their home games, 0-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Kansas City Chiefs 27-21. Justin Herbert was the starting QB and he completed 25/34 passes for 318 passing yards, 3 touchdowns, and 0 interceptions. Omarion Hampton led the team in rushing yards with 48. Quentin Johnston led the receivers with 79 receiving yards on 5 receptions and 2 TDs. Derwin James Jr. led the defense in that game with 5 solo tackles and 2 assisted tackles while Daiyan Henley and Da'Shawn Hand each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Raiders are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New England Patriots 20-13. Geno Smith was the starting QB and he completed 24/34 passes for 362 passing yards, 1 touchdown, and 1 interception. Ashton Jeanty led the team in rushing yards with 38 and 1 TD. Brock Bowers led the receivers with 103 receiving yards on 5 receptions. Devin White led the defense in that game with 8 solo tackles and 3 assisted tackles while Tyree Wilson, Malcolm Koonce, Jonah Laulu, and Maxx Crosby each led the defense in sacks with 1. Isaiah Pola-Mao came away with the only interception for them in that one.
Chargers vs Raiders Prediction
The current betting odds have the Chargers listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The Chargers have a 1-0 record overall this season and they looked great in their season opener. They opened the season in Brazil against the Chiefs and they picked up a big win which could have big implications on the division toward the end of the year. They beat the Chiefs 27-21, but the score is a lot closer than the game actually was. The Chargers bullied the Chiefs all night on both sides of the ball, and they are going to do the same in another divisional game here. They have a lot of momentum from that win that they can carry into this game and they have extra rest on their side too. Meanwhile, the Raiders have a 1-0 record overall this season and they looked great in their season opener. They beat the Patriots on the road 20-13 and their offense looked a lot better now that they have some stability with Geno Smith. They also have a lot more talent on this offense than they have had in recent years, but they were also playing against the Patriots in week 1 who had one of the worst records in the NFL last season, and they still struggled to pull away in that one. Now they have some momentum coming into this home opener, but even with all of the big changes they made in the off-season, the Chargers have a much better team this year and will be motivated to get ahead in the division with another win. The best way to place a bet here is on the Chargers to cover the spread in this game.
Chargers Raiders Prediction: Our NFL Pick for Monday, September 15, 2025 (10:00 pm ET start time) is Chargers 34 Raiders 14.
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NFL Betting Trends
Los Angeles Chargers: 7-1 ATS as a favorite of 3.5 to 9.5 points. 6-3 ATS on the road after 1 or more consecutive wins. 7-2 ATS on the road in games played on turf. 6-1 UNDER in a road game where the total is between 42.5 and 49 points. 3-0 UNDER after a win by 6 or less points.
Las Vegas Raiders: 4-8 ATS as an underdog of 3.5 to 9.5 points. 6-10 ATS after playing their last game on the road. 10-6 UNDER in all games where the total is between 42.5 and 49 points. 4-0 UNDER when playing on Monday night.
Key Injuries
Los Angeles Chargers: E. Molden (CB) Injured - Hamstring. D. Perryman (LB) Injured - Ankle. D. Phillips (LB) Injured - Toe. T. Still (CB) Injured - Calf.
Las Vegas Raiders: B. Bowers (TE) Injured - Knee. E. Roberts (LB) Injured - Elbow.
Notable Quotes
“It’s monumental. September 5th will go down in some Charger lore, in my opinion. It was a big win.” - Jim Harbaugh after his team’s win against the Chiefs in their last game.
“Geno had a regular game today. I don't think it was a big statement game or anything like that. I just think it was what he does.” - Pete Carroll after his team’s win against the Patriots in their last game.
Starting Lineups
Los Angeles Chargers
WR Johnston, Quentin
WR Allen, Keenan
WR McConkey, Ladd
TE Dissly, Will
QB Herbert, Justin
RB Hampton, Omarion
FB Matlock, Scott
Las Vegas Raiders
WR Thornton Jr., Dont'e
WR Tucker, Tre
WR Meyers, Jakobi
TE Bowers, Brock
QB Smith, Geno
RB Jeanty, Ashton
Statistical Leaders
Los Angeles Chargers
Passing: J. Herbert (318)
Rushing: O. Hampton (48)
Receiving: Q. Johnston (79)
Touchdowns: Q. Johnston (2)
Las Vegas Raiders
Passing: G. Smith (362)
Rushing: A. Jeanty (38)
Receiving: B. Bowers (103)
Touchdowns: A. Jeanty (1)
Coaches:
Los Angeles Chargers: Jim Harbaugh (2nd season)
Las Vegas Raiders: Pete Carroll (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
