by Rod Pearson
Wednesday, Dec 17, 2025
Game Time: 1:00 pm ET, Sunday, December 21, 2025
Venue: AT&T Stadium, Arlington, TX
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chargers +2.5, Cowboys -2.5; Over/Under: 49.5 points
Bet365: Point Spread: Chargers +2, Cowboys -2; Over/Under: 49.5 points
BetMGM: Point Spread: Chargers +2.5, Cowboys -2.5; Over/Under: 49.5 points
Season Record
Los Angeles Chargers: 10-4 (2nd place, AFC West)
Dallas Cowboys: 6-7-1 (2nd place, NFC East)
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Recent Form
Los Angeles Chargers: won their last game on the road against the Kansas City Chiefs 16-13.
Dallas Cowboys: lost their last game at home against the Minnesota Vikings 34-26.
Los Angeles Chargers vs Dallas Cowboys Preview and Analysis
The Chargers are entering this game with a 10-4 record overall and they have a 5-0 record in their divisional games too. They are 5-2 in their home games, 4-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Kansas City Chiefs 16-13. Justin Herbert was the starting QB and he completed 19/29 passes for 210 passing yards, 1 touchdown, and 1 interception. Omarion Hampton led the team in rushing yards with 61. Oronde Gadsden II led the receivers with 61 receiving yards on 4 receptions. Denzel Perryman led the defense in that game with 4 solo tackles and 5 assisted tackles while Odafe Oweh and Tuli Tuipulotu each led the defense in sacks with 2. Derwin James Jr. and Daiyan Henley each came away with 1 interception for them in that one.
The Cowboys are entering this game with a 6-7-1 record overall and they have a 3-1 record in their divisional games too. They are 4-2-1 in their home games, 2-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Minnesota Vikings 34-26. Dak Prescott was the starting QB and he completed 23/38 passes for 294 passing yards, 0 touchdowns, and 0 interceptions. Javonte Williams led the team in rushing yards with 91 and 1 TD. CeeDee Lamb led the receivers with 111 receiving yards on 6 receptions. DeMarvion Overshown led the defense in that game with 4 solo tackles and 3 assisted tackles while no one on the defense recorded a sack for them. Quinnen Williams came away with the only interception for them in that one.
Chargers vs Cowboys Prediction
The current betting odds have the Chargers listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. The Chargers have looked really good in their games this season with their 10-4 record overall which has them right near the top of the AFC West. They have been a good road team too with their 4-2 road record this year. Meanwhile, the Cowboys haven't looked great in their games this season with their 6-7-1 record overall, but that record has them right near the top of the NFC East. They have looked a lot better on their home field though with their 4-2-1 home record this season. The Cowboys are in a tough position here since they are technically still alive to win the division and make the playoffs, but they don't control anything. They would need the Eagles to lose out just to have a chance, and they really hurt themselves last week with a 34-26 home loss to the Vikings. They have had a great offense all season with a lot of talent all over, but they have also had one of the worst defenses in the NFL and they haven't been able to overcome that in a lot of their games. The Chargers are off a 16-13 win over the Chiefs in their last one and they are going to have a ton of momentum from that road win that ended the Chiefs season. The Chargers have been dealing with a ton of injuries this season too, but they continue to find ways to win games and will do the same here. The defense has also looked a lot better lately, and they are still able to win the division over the Broncos so this is a big game for them. The Chargers keep finding ways to win games despite their injuries so look for them to keep rolling in this game. The best way to place a bet here is on the Chargers to cover the spread in this game.
Chargers Cowboys Prediction: Our NFL Pick for Sunday, December 21, 2025 (1:00 pm ET start time) is Chargers 31 Cowboys 28.
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NFL Betting Trends
Los Angeles Chargers: 22-13 ATS against NFC East division opponents. 23-9 ATS in a road game where the total is greater than or equal to 49.5. 23-17 ATS off a road win against a division rival. 6-1 UNDER as a road underdog.
Dallas Cowboys: 4-9 ATS in all games where the total is greater than or equal to 49.5. 4-7 ATS when playing against a good team (Win Pct. 60% to 75%). 2-11 ATS at home off an upset loss as a home favorite. 5-2 UNDER off 3 or more consecutive overs.
Key Injuries
Los Angeles Chargers: None.
Dallas Cowboys: None.
Notable Quotes
“It’s a ball team. This is a ball team. Starting to think this is my favorite ball team that I’ve ever been on. I’ve been on a lot of teams, none better than this team. It’s a ball team. A real ball team. Love these guys.” - Jim Harbaugh after his team’s win against the Chiefs in their last game.
“We never got to the point where I felt like we were able to just kind of seize momentum. There wasn’t a momentum-changing play in any regard other than probably the interception early in the game.” - Brian Schottenheimer after his team’s loss against the Vikings in their last game.
Starting Lineups
Los Angeles Chargers
WR Harris, Tre'
WR Allen, Keenan
WR McConkey, Ladd
TE Gadsden, Oronde
QB Herbert, Justin
RB Hampton, Omarion
FB Matlock, Scott
Dallas Cowboys
WR Pickens, George
WR Lamb, CeeDee
WR Flournoy, Ryan
TE Ferguson, Jake
QB Prescott, Dak
RB Williams, Javonte
FB Luepke, Hunter
Statistical Leaders
Los Angeles Chargers
Passing: Justin Herbert (3,191)
Rushing: Kimani Vidal (620)
Receiving: Ladd McConkey (715)
Touchdowns: Quentin Johnston (7)
Dallas Cowboys
Passing: Dak Prescott (3,931)
Rushing: Javonte Williams (1,113)
Receiving: George Pickens (1,212)
Touchdowns: Javonte Williams (12)
Coaches:
Los Angeles Chargers: Jim Harbaugh (2nd season)
Dallas Cowboys: Brian Schottenheimer (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
