by Rod Pearson
Thursday, Sep 18, 2025
Game Time: 1:00 pm ET, Sunday, September 21, 2025
Venue: Northwest Stadium, Landover, MD
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Raiders +3, Commanders -3; Over/Under: 44.5 points
Bet365: Point Spread: Raiders +3.5, Commanders -3.5; Over/Under: 44 points
BetMGM: Point Spread: Raiders +3.5, Commanders -3.5; Over/Under: 44 points
Season Record
Las Vegas Raiders: 1-1 (2nd place, AFC West)
Washington Commanders: 1-1 (2nd place, NFC East)
Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the NFL on a 13-7 NFL RUN for +$5,470 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Las Vegas Raiders: lost their last game at home against the Los Angeles Chargers 20-9.
Washington Commanders: lost their last game on the road against the Green Bay Packers 27-18.
Las Vegas Raiders vs Washington Commanders Preview and Analysis
The Raiders are entering this game with a 1-1 record overall and they have a 0-1 record in their divisional games too. They are 0-1 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Los Angeles Chargers 20-9. Geno Smith was the starting QB and he completed 24/43 passes for 180 passing yards, 0 touchdowns, and 3 interceptions. Ashton Jeanty led the team in rushing yards with 43. Jakobi Meyers led the receivers with 68 receiving yards on 6 receptions. Devin White led the defense in that game with 6 solo tackles and 2 assisted tackles while Jonah Laulu led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.
The Commanders are entering this game with a 1-1 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Green Bay Packers 27-18. Jayden Daniels was the starting QB and he completed 24/42 passes for 200 passing yards, 2 touchdowns, and 0 interceptions. Austin Ekeler led the team in rushing yards with 17. Zach Ertz led the receivers with 64 receiving yards on 6 receptions and 1 TD. Mike Sainristil and Marshon Lattimore each led the defense in that game with 5 solo tackles and 1 assisted tackle while Dorance Armstrong led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Raiders vs Commanders Prediction
The current betting odds have the Commanders listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Commanders have a 1-1 record overall this year and they are off their first loss of the season. They lost to the Packers 27-18 and could be without their starting QB now, but they played that game on Thursday night so they have had extra time to prepare and that puts them in a much better situation at home. Meanwhile, the Raiders have a 1-1 record overall this season and they are off their first loss of the season too. They lost at home to the Chargers 20-9 and they had plenty of chances late in that game to come back, but they kept turning the ball over. That game was also on Monday night so that puts them at a big rest disadvantage here. The Raiders have made a lot of changes to the team this season with a new head coach and they are starting to head in the right direction, but they were still one of the worst teams in the NFL last season and have a lot of work to do. The Commanders are in a better situation here with the rest and their 2nd year coach. Mariota is not a terrible backup either so if he needs to play this week they will still have success against this Raiders defense. This is a good situation for the Commanders to bounce back at home with a big rest advantage. The best way to place a bet here is on the Commanders to cover the spread in this game.
Raiders Commanders Prediction: Our NFL Pick for Sunday, September 21, 2025 (1:00 pm ET start time) is Commanders 21 Raiders 13.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Las Vegas Raiders Washington Commanders prediction, be sure to drop by every day for our weekly NFL predictions and previews.
NFL Betting Trends
Las Vegas Raiders: 5-1 ATS off a home loss. 10-3 ATS after playing a game at home. 7-3 ATS after a game with a turnover margin of -2 or worse. 11-6 UNDER in all games where the total is between 42.5 and 49 points. 8-2 UNDER in non-conference games.
Washington Commanders: 40-63 ATS as a favorite of 3.5 to 9.5 points. 63-88 ATS off a road loss. 61-40 UNDER as a favorite of 3.5 to 9.5 points. 4-0 UNDER at home in September games.
Key Injuries
Las Vegas Raiders: B. Bowers (TE) Injured - Knee. J. Chinn (S) Injured - Pectoral. J. Powers-Johnson (C) Injured - Concussion.
Washington Commanders: J. Bates (TE) Injured - Groin. N. Brown (WR) Injured - Groin. J. Daniels (QB) Injured - Knee. Z. Ertz (TE) Injured - NIR - Rest. V. Miller (LB) Injured - NIR - Rest. L. Tunsil (OT) Injured - NIR - Rest. T. Amos (CB) Injured - Shoulder. B. Coleman (OT) Injured - Shoulder. J. McNichols (RB) Injured - Hamstring. C. Yankoff (TE) Injured - Hip.
Notable Quotes
"He ran the ball well. I thought he hit stuff well. And he went the wrong way on a play and so that was unfortunate and mixes up the whole play. Geno [Smith] goes this way. He goes that way. He's still getting it.” - Pete Carroll on Ashton Jeanty after his team’s loss against the LA Chargers in their last game.
“We'll use the weekend to see where we're at from the injuries. I don't want to make a guess.” - Dan Quinn after his team’s loss against the Packers in their last game.
Starting Lineups
Las Vegas Raiders
WR Thornton Jr., Dont'e
WR Tucker, Tre
WR Meyers, Jakobi
TE Bowers, Brock
QB Smith, Geno
RB Jeanty, Ashton
Washington Commanders
WR McLaurin, Terry
WR Lane, Jaylin
WR Samuel, Deebo
TE Ertz, Zach
QB Mariota, Marcus
RB Ekeler, Austin
Statistical Leaders
Las Vegas Raiders
Passing: G. Smith (542)
Rushing: A. Jeanty (81)
Receiving: J. Meyers (165)
Touchdowns: A. Jeanty (1)
Washington Commanders
Passing: J. Daniels (433)
Rushing: J. Croskey-Merritt (99)
Receiving: D. Samuel (121)
Touchdowns: Z. Ertz (2)
Coaches:
Las Vegas Raiders: Pete Carroll (1st season)
Washington Commanders: Dan Quinn (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
