Kentucky Wildcats vs Vanderbilt Commodores Prediction, Picks and Game Preview - 11/22/2025

Game Time: 3:30 pm ET, Saturday, November 22, 2025

Venue:  FirstBank Stadium, Nashville, TN

Where to Watch:  ESPN

DraftKings:  Point Spread:  Kentucky +10, Vanderbilt -10; Over/Under:  54.5 points

Bet365:  Point Spread:  Kentucky +9.5, Vanderbilt -9.5; Over/Under:  54 points

BetMGM:  Point Spread:  Kentucky +9.5, Vanderbilt -9.5; Over/Under:  53.5 points

Kentucky Wildcats:  5-5 (2-5) (11th place, SEC)

Vanderbilt Commodores:  8-2 (4-2) (5th place, SEC)

Do not miss out on our expert handicapper analysis! Brian Bitler is on a HOT STREAK in college football on an 8-1 CFB RUN for +$6,900 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Kentucky Wildcats:  won their last game at home against the Tennessee Tech Golden Eagles 42-10.

Vanderbilt Commodores:  won their last game at home against the Auburn Tigers 45-38 in overtime. 

Kentucky is entering this game with a 5-5 record overall and they have a 2-5 record in their conference games too. They are 4-3 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Tennessee Tech 42-10. Cutter Boley was the starting QB and he completed 18/21 passes for 236 passing yards, 1 touchdown, and 0 interceptions. Dante Dowdell led the team in rushing yards with 87 and 1 TD. Kendrick Law led the receivers with 124 receiving yards on 11 receptions. Daveren Rayner led the defense in that game with 5 solo tackles and 0 assisted tackles while Jonquis Hardaway led the defense in sacks with 1. Cam Dooley came away with the only interception for them in that one.

 

 

 

Vanderbilt is entering this game with an 8-2 record overall and they have a 4-2 record in their conference games too. They are 6-0 in their home games, 2-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Auburn 45-38 in OT. Diego Pavia was the starting QB and he completed 25/33 passes for 377 passing yards, 3 touchdowns, and 0 interceptions. Diego Pavia led the team in rushing yards with 112 and 1 TD. Tre Richardson led the receivers with 124 receiving yards on 3 receptions and 1 TD. Bryan Longwell led the defense in that game with 11 solo tackles and 0 assisted tackles while CJ Heard and Keanu Koht each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Kentucky listed as a 10 point underdog in this game according to Draftkings Sportsbook. Kentucky hasn't looked great in their games this season with their 5-5 record overall and their 2-5 conference record which has them right near the bottom of the SEC. As bad as they have looked this season, They have looked a lot better in their games lately and haven't been getting blown out in a lot of games either. Meanwhile, Vanderbilt has looked really good in their games this season with their 8-2 record overall and their 4-2 conference record which has them right near the top of the SEC. They have been rolling in their games all year as they have some nice wins under their belt and continue to find ways to win games, but lately they have been playing in a lot more fights. They are off a 45-38 win over Auburn in their last one, a game which they needed OT to win, and they have been trailing more in their last few games too. They haven't won a game by more than a TD since September either. They have a really good offense that is going to put up points, but their defense hasn't looked great with the number of points they have been giving up all year. This Kentucky defense has also looked a lot better lately as they have been giving some of their conference opponents trouble over the last month, and that offense has looked a lot better since making a change at QB too. Kentucky can do enough in this game to keep it close like they have in some of their other conference games this year. The best way to place a bet here is on Kentucky to cover the spread in this game. 

Kentucky Vanderbilt Prediction:  Our NCAAF Pick for Saturday, November 22, 2025 (3:30 pm ET start time) is Vanderbilt 27 Kentucky 24.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Kentucky Wildcats Vanderbilt Commodores prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Kentucky Wildcats: 0-3 ATS after 3 or more consecutive wins against the spread. 4-7 ATS vs. good passing teams averaging 250 or more passing yards/game. 8-0 OVER as an underdog of 3.5 to 10 points. 10-3 OVER vs. good offensive  teams - scoring 31 or more points/game.

Vanderbilt Commodores: 5-1 ATS after a bye week. 8-3 ATS at home off a home win against a conference rival. 7-3 OVER as a home favorite. 7-2 OVER in a home game where the total is between 49.5 and 56. 5-1 OVER after allowing 37 points or more last game.

Kentucky Wildcats:  J. Wilcox (RB) Questionable - Personal. D. Washington Jr. (WR) Questionable - Undisclosed. T. Stellato (WR) Questionable - Undisclosed. D. Smith (LB) Questionable - Undisclosed. J. Smith (CB) Questionable - Undisclosed. A. Selm (OG) Questionable - Undisclosed. T. Nichols (CB) Questionable - Undisclosed. E. Brown (TE) Questionable - Undisclosed. D. Waller Jr. (CB) Questionable - Undisclosed.

Vanderbilt Commodores:  C. Gillespie (RB) Questionable - Undisclosed. Y. Ouattara (DL) Questionable - Undisclosed. N. Jefferson (DL) Questionable - Undisclosed. D. Dickey (QB) Questionable - Undisclosed. V. Hinton (CB) Questionable - Undisclosed.

“We had talked about it all the time to continue to play with great effort, continue to try to improve in the execution. It doesn’t matter who we’re playing. We just got to try to continue to worry about ourselves, continue to get better. I love this team’s attitude and effort, and really greatly appreciate the seniors playing for the last time in Kroger Field. Some of those guys have been around a long time, some of them are new, but all of them have had a great impact on our program, and they’ve shown great leadership, and I greatly appreciate them and their families being here today to celebrate a good victory. And now it’s on to the next, and we’ve been handling it very much with the mindset of one week at a time, one day at a time. Appreciate the effort, and them preparing and taking care of business. And now it’s on to the next opponent, and we’ll get back to work.” - Mark Stoops after his team’s win against Tennessee Tech in their last game. 

“We’re out of opportunities. Everything’s at stake, and the mission is winning.” - Clark Lea after his team’s win against Auburn in their last game. 

WR Gilmore IV, Hardley

WR Maclin, Ja'Mori

WR Law, Kendrick

TE Kattus, Josh

TE Rodriguez, Willie

QB Boley, Cutter

RB McGowan, Seth

WR Sherrill, Junior

WR Richardson, Tre

WR Hoskins, Richie

TE Stowers, Eli

QB Pavia, Diego

RB Alexander, Sedrick

Passing: Cutter Boley (1,780)

Rushing: Seth McGowan (693)

Receiving: Kendrick Law (519)

Touchdowns: Seth McGowan (12)

Passing: Diego Pavia (2,440)

Rushing: Diego Pavia (613)

Receiving: Eli Stowers (669)

Touchdowns: Sedrick Alexander (12)

Coaches:

Kentucky Wildcats: Mark Stoops (13th season)

Vanderbilt Commodores: Clark Lea (5th season)