Kansas City Chiefs vs Tennessee Titans Prediction, Preview and Odds - 12/21/2025

Game Time: 1:00 pm ET, Sunday, December 21, 2025

Venue:  Nissan Stadium, Nashville, TN

Where to Watch:  CBS

DraftKings:  Point Spread:  Chiefs -3.5, Titans +3.5; Over/Under:  37.5 points

Bet365:  Point Spread:  Chiefs -3, Titans +3; Over/Under:  37.5 points

BetMGM:  Point Spread:  Chiefs -3.5, Titans +3.5; Over/Under:  37.5 points

Kansas City Chiefs:  6-8 (3rd place, AFC West)

Tennessee Titans:  2-12 (4th place, AFC South)

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Kansas City Chiefs:  lost their last game at home against the Los Angeles Chargers 16-13.

Tennessee Titans:  lost their last game on the road against the San Francisco 49ers 37-24.

The Chiefs are entering this game with a 6-8 record overall and they have a 1-3 record in their divisional games too. They are 5-3 in their home games, 1-4 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Los Angeles Chargers 16-13. Patrick Mahomes was the starting QB and he completed 16/28 passes for 189 passing yards, 0 touchdowns, and 3 interceptions. Isiah Pacheco led the team in rushing yards with 21. Travis Kelce led the receivers with 70 receiving yards on 7 receptions. Drue Tranquill led the defense in that game with 8 solo tackles and 6 assisted tackles while Charles Omenihu led the defense in sacks with 1.5. Ashton Gillotte came away with the only interception for them in that one.

 

 

 

The Titans are entering this game with a 2-12 record overall and they have a 0-5 record in their divisional games too. They are 0-7 in their home games, 2-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the San Francisco 49ers 37-24. Cameron Ward was the starting QB and he completed 18/29 passes for 170 passing yards, 2 touchdowns, and 0 interceptions. Tony Pollard led the team in rushing yards with 104 and 1 TD. Gunnar Helm led the receivers with 49 receiving yards on 4 receptions and 1 TD. Cedric Gray led the defense in that game with 7 solo tackles and 9 assisted tackles while Jeffery Simmons and Jaylen Harrell each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the Titans listed as a 3.5 point underdog in this game according to Draftkings Sportsbook. The Titans have looked terrible in their games this season with their 2-12 record overall which has them right at the bottom of the AFC South with one of the worst records in the entire NFL. They have looked terrible on their home field too with their 0-7 home record this year. Meanwhile, the Chiefs haven't looked good in their games this season with their 6-8 record overall which has them right near the bottom of the AFC West. They have been a terrible road team too with their 1-4 road record this year. The Chiefs are off a 16-13 loss at home to the Chargers in their last one and that loss officially eliminated them from playoff contention. They also lost Mahomes to a torn ACL so it is tough to see where the team's motivation is coming into this one. The Titans have been one of the worst teams in the NFL all season, but they didn't look terrible in their 37-24 loss to the 49ers last week and they have shown a lot more fight lately, even beating the Browns on the road 2 weeks ago. The Titans have players that are still playing for jobs next season and with the current situation surrounding the Chiefs, this is a great opportunity for the Titans to win their first home game of the year. The Chiefs offense hasn't looked great this year, even with Mahomes playing, so Minshew isn't going to make it look any better, and the defense has also been a big issue too. The best way to place a bet here is on the Titans to cover the spread in this game. 

Chiefs Titans Prediction:  Our NFL Pick for Sunday, December 21, 2025 (1:00 pm ET start time) is Titans 21 Chiefs 18.

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Kansas City Chiefs: 4-1 ATS off a home loss. 6-3 ATS vs. poor passing defenses - allowing 7 or more passing yards/att. 3-0 ATS on the road after a loss by 6 or less points. 9-2 UNDER in all games where the total is between 35.5 and 42 points.

Tennessee Titans: 15-32 ATS in all games. 7-18 ATS as an underdog of 3.5 to 9.5 points. 10-24 ATS against conference opponents. 10-4 UNDER when playing against a team with a losing record.

Kansas City Chiefs:  None.

Tennessee Titans:  None.

“It didn't look good.” - Andy Reid on the injury to Mahomes after his team’s loss against the LA Chargers in their last game. 

“You’ve got to be able to get off the field. When you convert at that high rate, that percentage, it’s tough. That’s when you give up all the points. So you’ve got to be able to get off the field on third down.” - Mike McCoy after his team’s loss against the 49ers in their last game. 

WR Smith-Schuster, JuJu

WR Worthy, Xavier

WR Rice, Rashee

TE Kelce, Travis

QB Minshew, Gardner

RB Hunt, Kareem

WR Ayomanor, Elic

WR Proche II, James

WR Dike, Chimere

TE Okonkwo, Chig

QB Ward, Cam

RB Pollard, Tony

Passing: Patrick Mahomes (3,587)

Rushing: Kareem Hunt (557)

Receiving: Travis Kelce (797)

Touchdowns: Kareem Hunt (9)

Passing: Cam Ward (2,638)

Rushing: Tony Pollard (847)

Receiving: Chig Okonkwo (459)

Touchdowns: Tony Pollard (5)

Coaches:

Kansas City Chiefs: Andy Reid (13th season)

Tennessee Titans: Mike McCoy (Interim)