by Rod Pearson
Friday, Sep 19, 2025
Game Time: 8:20 pm ET, Sunday, September 21, 2025
Venue: MetLife Stadium, East Rutherford, NJ
Where to Watch: NBC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chiefs -6, Giants +6; Over/Under: 45.5 points
Bet365: Point Spread: Chiefs -6, Giants +6; Over/Under: 45 points
BetMGM: Point Spread: Chiefs -6.5, Giants +6.5; Over/Under: 45 points
Season Record
Kansas City Chiefs: 0-2 (4th place, AFC West)
New York Giants: 0-2 (4th place, NFC East)
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Kansas City Chiefs: lost their last game at home against the Philadelphia Eagles 20-17.
New York Giants: lost their last game on the road against the Dallas Cowboys 40-37 in overtime.
Kansas City Chiefs vs New York Giants Preview and Analysis
The Chiefs are entering this game with a 0-2 record overall and they have a 0-1 record in their divisional games too. They are 0-1 in their home games, 0-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Philadelphia Eagles 20-17. Patrick Mahomes was the starting QB and he completed 16/29 passes for 187 passing yards, 1 touchdown, and 1 interception. Patrick Mahomes led the team in rushing yards with 66 and 1 TD. Travis Kelce led the receivers with 61 receiving yards on 4 receptions. Drue Tranquill led the defense in that game with 4 solo tackles and 2 assisted tackles while Omarr Norman-Lott led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Giants are entering this game with a 0-2 record overall and they have a 0-2 record in their divisional games too. They are 0-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Dallas Cowboys 40-37 in OT. Russell Wilson was the starting QB and he completed 30/41 passes for 450 passing yards, 3 touchdowns, and 1 interception. Cameron Skattebo led the team in rushing yards with 45 and 1 TD. Malik Nabers led the receivers with 167 receiving yards on 9 receptions and 2 TDs. Paulson Adebo led the defense in that game with 11 solo tackles and 2 assisted tackles while Kayvon Thibodeaux, Brian Burns, and Elijah Garcia each led the defense in sacks with 1. Andru Phillips came away with the only interception for them in that one.
Chiefs vs Giants Prediction
The current betting odds have the Chiefs listed as a 6 point favorite in this game according to Draftkings Sportsbook. The Chiefs haven't looked good in their games this season with their 0-2 record overall. They haven't been able to do much on offense in their 2 games, but they also opened the season with 2 really good teams who both have good defenses. Now the Chiefs are catching a break on Sunday night with a game against one of the worst teams in the NFL, and they desperately need a get right win here. This is a great situation for them to bounce back against that Giants defense that gave up 40 points last week, and the Chiefs still have a great defense that is going to make the Giants offense look a lot more like they did in week 1 compared to last week. Meanwhile, the Giants haven't looked good in their games this season with their 0-2 record overall. They have already lost 2 games in their division and they did look a lot better last week, but they still lost in heartbreaking fashion in OT. Their defense hasn't looked good in either game this season and now they have to play in a stand alone game against one of the best teams in the NFL who desperately need their first win of the season. This is a great situation for the Chiefs to bounce back and a terrible situation for the Giants, running into the Chiefs at the wrong time. The best way to place a bet here is on the Chiefs to cover the spread in this game.
Chiefs Giants Prediction: Our NFL Pick for Sunday, September 21, 2025 (8:20 pm ET start time) is Chiefs 31 Giants 7.
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NFL Betting Trends
Kansas City Chiefs: 5-2 ATS as a road favorite of 7 points or less. 3-0 ATS off a home loss. 8-4 ATS on the road after playing a game at home. 26-17 UNDER in all games. 7-1 UNDER as a road favorite of 7 points or less.
New York Giants: 13-21 ATS in all games. 5-10 ATS in all games where the total is between 42.5 and 49 points. 2-7 ATS in the first month of the season. 12-4 UNDER as a home underdog of 7 points or less. 11-5 UNDER in all games where the total is between 42.5 and 49 points.
Key Injuries
Kansas City Chiefs: A. Gillotte (DL) Injured - Elbow. P. Mahomes (QB) Injured - Wrist. C. Omenihu (DL) Injured - Hand. J. Taylor (OT) Injured - Knee. D. Tranquill (LB) Injured - Knee. H. Brown (WR) Injured - Ankle. M. Danna (DL) Injured - Quad. K. Fulton (CB) Injured - Ankle. J. Royals (WR) Injured - Knee. X. Worthy (WR) Injured - Shoulder. J. Simmons (OT) Injured - Illness.
New York Giants: D. Flannigan-Fowles (LB) Injured - Calf. C. Golston (DL) Injured - Ankle. D. Muasau (LB) Injured - Concussion. G. Olszewski (WR) Injured - Back. R. Nunez-Roches Sr. (DL) Injured - Foot. W. Robinson (WR) Injured - Foot. J. Runyan (OG) Injured - Back. J. Schmitz Jr. (C) Injured - Toe. D. Slayton (WR) Injured - Groin. A. Thomas (OT) Injured - Foot. T. Tracy Jr. (RB) Injured - Calf. R. Robertson-Harris (DL) Injured - Knee. C. Skattebo (RB) Injured - Ankle.
Notable Quotes
“I’ll take full responsibility for that game.” - Andy Reid after his team’s loss against the Eagles in their last game.
“I think it just depends on what we want to do for that particular week, but I think they’ve both earned playing time with some of the things they’ve done, and they’ll both need to help us.” - Brian Daboll on the position battle between Deonte Banks and Cor’Dale Flott.
Starting Lineups
Kansas City Chiefs
WR Smith-Schuster, JuJu
WR Thornton, Tyquan
WR Brown, Hollywood
TE Kelce, Travis
QB Mahomes, Patrick
RB Pacheco, Isiah
New York Giants
WR Nabers, Malik
WR Slayton, Darius
WR Robinson, Wan'Dale
TE Johnson, Theo
QB Wilson, Russell
RB Skattebo, Cam
Statistical Leaders
Kansas City Chiefs
Passing: P. Mahomes (445)
Rushing: P. Mahomes (123)
Receiving: H. Brown (129)
Touchdowns: P. Mahomes (2)
New York Giants
Passing: R. Wilson (618)
Rushing: R. Wilson (67)
Receiving: M. Nabers (238)
Touchdowns: M. Nabers (2)
Coaches:
Kansas City Chiefs: Andy Reid (13th season)
New York Giants: Brian Daboll (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
