Kansas City Chiefs vs Los Angeles Chargers Prediction, Preview and Odds - 09/05/2025

Game Time: 8:00 pm ET, Friday, September 5, 2025

Venue:  Neo Química Arena, São Paulo, Brazil

Where to Watch:  YouTube

DraftKings:  Point Spread:  Chiefs -3, Chargers +3; Over/Under:  45.5 points

Bet365:  Point Spread:  Chiefs -3, Chargers +3; Over/Under:  45.5 points

BetMGM:  Point Spread:  Chiefs -3, Chargers +3; Over/Under:  45.5 points

Kansas City Chiefs:  0-0 (AFC West)

Los Angeles Chargers:  0-0 (AFC West)

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Kansas City Chiefs:  N/A

Los Angeles Chargers:  N/A

The Chiefs finished last season with a 15-2 record overall and they were 5-1 in their division games too. They had an 8-0 record in their home games and had a 7-2 record in their road games, but they will be at a neutral site in this game. Last season, their offense was averaging 22.6 points per game and their defense was allowing an average of 19.2 points per game. Their offense was also averaging 327.6 yards per game and their defense was allowing an average of 320.6 yards per game. Patrick Mahomes led the team in passing yards with 3,928, Kareem Hunt led the team in rushing yards with 728, and Travis Kelce led the team in receiving yards with 823.

The Chargers finished last season with an 11-6 record overall and they were 4-2 in their division games too. They had a 5-3 record in their home games and had a 6-3 record in their road games, but they will be at a neutral site for this game. Last season, their offense was averaging 23.6 points per game and their defense was allowing an average of 17.7 points per game. Their offense was also averaging 324.2 yards per game and their defense was allowing an average of 324.4 yards per game. Justin Herbert led the team in passing yards with 3,870, J.K. Dobbins led the team in rushing yards with 905, and Ladd McConkey led the team in receiving yards with 1,149.

The current betting odds have the Chiefs listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Chiefs had a great season last year, finishing 15-2 overall and going all the way to the Super Bowl before losing to the Eagles. They came up short last season, but they still have 2 Super Bowls over the last 3 seasons and are one of the best teams in the NFL. They were also embarrassed in that Super Bowl game against the Eagles so they are going to be chomping at the bit to come out strong here and put that last game behind them. Meanwhile, the Chargers had a great season in the first year of Jim Harbaugh being head coach. They went 11-6 overall and made it to the playoffs, but they once again lost early in the playoffs and haven't been able to get over that hump. Harbaugh will be looking to pick up where they left off, but this will be a tough game to win at a neutral site in Brazil. The Chargers don't have the experience in these international games that the Chiefs have in recent seasons. The Chiefs have played multiple international games over the last few seasons while the Chargers haven't played one since 2019. The Chargers improved a lot with Harbaugh last season and they are going to be a good team once again, but the Chiefs are still the team to beat in the division. This isn't a great season opener for the Chargers with the Chiefs sitting on a Super Bowl loss for an entire off-season. The best way to place a bet here is on the Chiefs to cover the spread in this game. 

Chiefs Chargers Prediction:  Our NFL Pick for Friday, September 5, 2025 (8:00 pm ET start time) is Chiefs 27 Chargers 20.

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Kansas City Chiefs: 12-4 ATS in games where the line is +3 to -3. 7-4 ATS on the road in games played on a grass field. 25-16 UNDER in all games. 21-13 UNDER as a favorite. 10-2 UNDER versus division opponents.

Los Angeles Chargers: 4-8 ATS as an underdog. 3-6 ATS in games played on a grass field. 20-14 UNDER in all games. 8-4 UNDER as an underdog. 10-5 UNDER in all games where the total is between 42.5 and 49 points. 

Kansas City Chiefs:  None.

Los Angeles Chargers:  None.

“Looks like the quarterbacks trust him. That’s a big part of it. As you watch, you see who the quarterbacks are going to, and there’s a certain trust that they’re developing here in that kid. So that kind of speaks for itself.” - Andy Reid on their rookie WR Jalen Royals.

"When Najee's ready to play he'll be ready to play. To take it past today would be going over the legal limit." - Jim Harbaugh on the injury to Najee Harris.

WR Worthy, Xavier

WR Brown, Hollywood

WR Remigio, Nikko

TE Kelce, Travis

QB Mahomes, Patrick

RB Pacheco, Isiah

WR Harris, Tre'

WR Allen, Keenan

WR McConkey, Ladd

TE Dissly, Will

QB Herbert, Justin

RB Hampton, Omarion

FB Matlock, Scott

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Kansas City Chiefs: Andy Reid (13th season)

Los Angeles Chargers: Jim Harbaugh (2nd season)