Kansas City Chiefs vs Buffalo Bills Prediction, Preview and Odds - 11/02/2025

Game Time: 4:25 pm ET, Sunday, November 2, 2025

Venue:  Highmark Stadium, Orchard Park, NY 

Where to Watch:  CBS

DraftKings:  Point Spread:  Chiefs -1.5, Bills +1.5; Over/Under:  52.5 points

Bet365:  Point Spread:  Chiefs -1.5, Bills +1.5; Over/Under:  52.5 points

BetMGM:  Point Spread:  Chiefs -2, Bills +2; Over/Under:  52.5 points

Kansas City Chiefs:  5-3 (3rd place, AFC West)

Buffalo Bills:  5-2 (2nd place, AFC East)

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Kansas City Chiefs:  won their last game at home against the Washington Commanders 28-7.

Buffalo Bills:  won their last game on the road against the Carolina Panthers 40-9.

The Chiefs are entering this game with a 5-3 record overall and they have a 1-1 record in their divisional games too. They are 4-1 in their home games, 1-1 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Washington Commanders 28-7. Patrick Mahomes was the starting QB and he completed 25/34 passes for 299 passing yards, 3 touchdowns, and 2 interceptions. Isiah Pacheco led the team in rushing yards with 58. Travis Kelce led the receivers with 99 receiving yards on 6 receptions and 1 TD. Chamarri Conner led the defense in that game with 5 solo tackles and 5 assisted tackles while George Karlaftis and Mike Danna each led the defense in sacks with 1. Mike Danna and Jack Cochrane each came away with 1 interception for them in that one.

 

 

 

The Bills are entering this game with a 5-2 record overall and they have a 2-1 record in their divisional games too. They are 3-1 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Carolina Panthers 40-9. Josh Allen was the starting QB and he completed 12/19 passes for 163 passing yards, 1 touchdown, and 0 interceptions. James Cook led the team in rushing yards with 216 and 2 TDs. Khalil Shakir led the receivers with 88 receiving yards on 6 receptions and 1 TD. Cole Bishop led the defense in that game with 3 solo tackles and 4 assisted tackles while Michael Hoecht led the defense in sacks with 1.5. A.J. Epenesa came away with the only interception for them in that one.

The current betting odds have the Chiefs listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Chiefs have looked good in their games this season with their 5-3 record overall, but that record has them right near the bottom of the AFC West in a competitive division. They had a slow start to the season and weren't looking great in their games, but they have been getting healthier and have now won 3 games in a row. Meanwhile, the Bills have looked really good in their games this season with their 5-2 record overall which has them right near the top of the AFC East. They had a really hot start to the season as they were 4-0 before losing 2 games in a row, but they came out of their bye week and beat up on the Panthers 40-9 on the road. They got their momentum back with that big win out of the bye week, but they have also been beating up on a lot of bad teams this season. Their offense has looked great as it usually does, but their defense has been a big issue in their games. That gives the Chiefs a big edge here since they have one of the best defenses in the NFL, and that defense hasn't been giving up many points at all lately. The Chiefs have the better defense in this game and that will be the key factor as the Chiefs continue to roll. The best way to place a bet here is on the Chiefs to cover the spread in this game. 

Chiefs Bills Prediction:  Our NFL Pick for Sunday, November 2, 2025 (4:25 pm ET start time) is Chiefs 27 Bills 24.

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Kansas City Chiefs: 14-6 ATS in games where the line is +3 to -3. 13-7 ATS vs. good offensive teams - scoring 24 or more points/game. 10-4 ATS versus good offensive teams - averaging 350 yards/game or more. 30-19 UNDER in all games. 5-0 UNDER in all games where the total is greater than or equal to 49.5.

Buffalo Bills: 5-9 ATS after a win by 14 or more points. 4-9 ATS in weeks 5 through 9. 9-3 UNDER ersus good offensive teams - averaging 5.65 yards/play or more. 8-4 UNDER versus good offensive teams - averaging 350 yards/game or more.

Kansas City Chiefs:  K. Hunt (RB) Injured - Ankle. J. Taylor (OT) Injured - Knee. H. Brown (WR) Injured - Illness. C. Omenihu (DL) Injured - Ankle. T. Smith (OG) Injured - Back. N. Bolton (LB) Injured - Knee. I. Pacheco (RB) Injured - Knee. B. Smith (RB) Injured - Toe. J. Simmons (OT) Injured - NIR - Personal.

Buffalo Bills:  M. Prater (K) Injured - Calf. J. Bosa (DL) Injured - Rest. M. Milano (LB) Injured - Pectoral. J. Phillips (DL) Injured - Rest. S. Thompson (LB) Injured - Hamstring. D. Jones (DL) Injured - Calf. T. Bernard (LB) Injured - Ankle. J. Palmer (WR) Injured - Knee. R. Davis (RB) Injured - Illness.

“There wasn't a lot of punting but there wasn't a lot of points. That doesn't normally happen.” - Andy Reid after his team’s win against the Commanders in their last game. 

“I think it's the way that our guys handle (the bye). Just making sure that we're practicing the right way. Coming off two losses it's been lingering with us, so we wanted to come out and put our best foot forward — and we did that.” - Josh Allen after their win against the Panthers in their last game.

WR Worthy, Xavier

WR Brown, Hollywood

WR Rice, Rashee

TE Kelce, Travis

QB Mahomes, Patrick

RB Hunt, Kareem

WR Shavers, Tyrell

WR Coleman, Keon

WR Shakir, Khalil

TE Kincaid, Dalton

QB Allen, Josh

RB Cook, James

FB Gilliam, Reggie

Passing: Patrick Mahomes (2,099)

Rushing: Isiah Pacheco (329)

Receiving: Travis Kelce (474)

Touchdowns: Kareem Hunt (5)

Passing: Josh Allen (1,560)

Rushing: James Cook (753)

Receiving: Khalil Shakir (356)

Touchdowns: James Cook (7)

Coaches:

Kansas City Chiefs: Andy Reid (13th season)

Buffalo Bills: Sean McDermott (9th season)