Jacksonville Jaguars vs Denver Broncos Prediction, Preview and Odds - 12/21/2025

Game Time: 4:05 pm ET, Sunday, December 21, 2025

Venue:  Empower Field at Mile High, Denver, CO

Where to Watch:  FOX

DraftKings:  Point Spread:  Jaguars +3, Broncos -3; Over/Under:  47.5 points

Bet365:  Point Spread:  Jaguars +3, Broncos -3; Over/Under:  47 points

BetMGM:  Point Spread:  Jaguars +3, Broncos -3; Over/Under:  46.5 points

Jacksonville Jaguars:  10-4 (1st place, AFC South)

Denver Broncos:  12-2 (1st place, AFC West)

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Jacksonville Jaguars:  won their last game at home against the New York Jets 48-20.

Denver Broncos:  won their last game at home against the Green Bay Packers 34-26.

The Jaguars are entering this game with a 10-4 record overall and they have a 3-1 record in their divisional games too. They are 6-1 in their home games, 4-2 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New York Jets 48-20. Trevor Lawrence was the starting QB and he completed 20/32 passes for 330 passing yards, 5 touchdowns, and 0 interceptions. Trevor Lawrence led the team in rushing yards with 51 and 1 TD. Travis Etienne Jr. led the receivers with 73 receiving yards on 3 receptions and 3 TDs. Antonio Johnson and Greg Newsome II each led the defense in that game with 5 solo tackles and 0 assisted tackles while Eric Murray, Dennis Gardeck, and B.J. Green II each led the defense in sacks with 1. Antonio Johnson, Montaric Brown, and Ventrell Miller each came away with 1 interception for them in that one.

 

 

 

The Broncos are entering this game with a 12-2 record overall and they have a 3-1 record in their divisional games too. They are 7-0 in their home games, 4-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Green Bay Packers 34-26. Bo Nix was the starting QB and he completed 23/34 passes for 302 passing yards, 4 touchdowns, and 0 interceptions. RJ Harvey led the team in rushing yards with 65 and 1 TD. Courtland Sutton led the receivers with 113 receiving yards on 7 receptions and 1 TD. Dre Greenlaw led the defense in that game with 5 solo tackles and 3 assisted tackles while Jonah Elliss and Dondrea Tillman each led the defense in sacks with 1. Riley Moss and Patrick Surtain II each came away with 1 interception for them in that one.

The current betting odds have the Jaguars listed as a 3 point underdog in this game according to Draftkings Sportsbook. The Jaguars have looked really good in their games this season with their 10-4 record overall which has them right at the top of the AFC West. They have been a good road team too with their 4-2 road record this year. Meanwhile, the Broncos have looked great in their games this season with their 12-2 record overall which has them right at the top of the AFC West with the best record in the entire NFL. They have looked great on their home field too with their 6-1 home record this season. The Broncos are off a 34-26 win over the Packers in their last one and they have been rolling in their games lately with 11 wins in a row now. As good as they have been on this run, they have been playing in a lot of tight games with how up and down their offense has been this season. They have one of the best defenses in the NFL, but the Jaguars also have a very good defense that can turn this game into a rock fight. The Jags are off a 48-20 win over the Jets in their last one and they have been rolling in their games lately with a lot of big wins by double digits. Their offense has been a lot more consistent lately too. The Jaguars have been rolling lately and they have the talent to keep this a tight game with the way the Broncos don't really pull away from their opponents. The best way to place a bet here is on the Jaguars to cover the spread in this game. 

Jaguars Broncos Prediction:  Our NFL Pick for Sunday, December 21, 2025 (4:05 pm ET start time) is Jaguars 23 Broncos 20.

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Jacksonville Jaguars: 19-10 ATS in all games where the total is between 42.5 and 49 points. 7-2 ATS after a win by 14 or more points. 7-2 ATS after a game with a turnover margin of +2 or better. 15-8 UNDER in games where the line is +3 to -3. 3-0 UNDER after a 2 game home stand.

Denver Broncos: 31-45 ATS off 3 or more consecutive overs. 14-21 ATS at home off a upset win as an underdog. 9-2 UNDER in a home game where the total is between 42.5 and 49 points. 9-0 UNDER vs. good teams - outscoring opponents by 6+ PPG on the season. 

Jacksonville Jaguars:  A. Armstead (DL) Injured - Hand. E. Cleveland (OG) Injured - Shoulder. J. Hines-Allen (DL) Injured - Illness. W. Little (OG) Injured - Concussion. T. Walker (DL) Injured - Knee. D. Striggow (DL) Injured - Ankle. J. McLeod (LB) Injured - Ankle. B. Tuten (RB) Injured - Finger.

Denver Broncos:  M. McGlinchey (OT) Injured - Neck. B. Powers (OG) Injured - Biceps. L. Wattenberg (C) Injured - Ankle. J. Strnad (LB) Injured - Foot. M. Mims Jr. (WR) Injured - Biceps. K. Reid (LB) Injured - Hamstring. P. Bryant (WR) Injured - Hamstring. R. Harvey (RB) Injured - Ribs.

“Definitely this is as confident as I've felt. Just the feeling in our locker room and our team and our offense, it's been fun. We've got to continue to build on that and not get complacent. There's still a lot more ahead for us.” - Trevor Lawrence after their win against the Jets in their last game. 

“Well, we talked about it at halftime and we said that's the habitat we've been living in.” - Sean Payton after his team’s win against the Packers in their last game. 

WR Thomas Jr., Brian

WR Meyers, Jakobi

WR Washington, Parker

TE Strange, Brenton

QB Lawrence, Trevor 

RB Etienne Jr., Travis

WR Sutton, Courtland

WR Humphrey, Lil'Jordan

WR Franklin, Troy

TE Trautman, Adam

QB Nix, Bo

RB Harvey, RJ

FB Prentice, Adam

Passing: Trevor Lawrence (3,210)

Rushing: Travis Etienne Jr. (949)

Receiving: Brian Thomas Jr. (691)

Touchdowns: Travis Etienne Jr. (12)

Passing: Bo Nix (3,256)

Rushing: J.K. Dobbins (772)

Receiving: Courtland Sutton (886)

Touchdowns: RJ Harvey (10)

Coaches:

Jacksonville Jaguars: Liam Coen (1st season)

Denver Broncos: Sean Payton (3rd season)