Jacksonville Jaguars vs Denver Broncos Prediction, Preview and Odds - 09/20/2026

Game Time: 4:05 pm ET, Sunday, September 20, 2026

Venue:  Empower Field at Mile High, Denver, CO

Where to Watch:  CBS

DraftKings:  Point Spread:  Jaguars +2.5, Broncos -2.5; Over/Under:  45.5 points

Bet365:  Point Spread:  Jaguars +2.5, Broncos -2.5; Over/Under:  45.5 points

BetMGM:  Point Spread:  Jaguars +2.5, Broncos -2.5; Over/Under:  45.5 points

Jacksonville Jaguars:  1-0 (1st place, AFC South)

Denver Broncos:  0-1 (3rd place, AFC West)

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Jacksonville Jaguars:  won their last game at home against the Cleveland Browns 34-10.

Denver Broncos:  lost their last game on the road against the Kansas City Chiefs 31-10.

The Jaguars are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Cleveland Browns 34-10. Trevor Lawrence was the starting QB and he completed 18/23 passes for 245 passing yards, 4 touchdowns, and 0 interceptions. Bhayshul Tuten led the team in rushing yards with 66. Parker Washington led the receivers with 83 receiving yards on 5 receptions and 1 TD. Ventrell Miller led the defense in that game with 10 solo tackles while Josh Hines-Allen and Travon Walker each led the defense in sacks with 1.5. Foyesade Oluokun came away with the only interception for them in that one.

 

 

 

The Broncos are entering this game with a 0-1 record overall and they have a 0-1 record in their divisional games too. They are 0-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Kansas City Chiefs 31-10. Bo Nix was the starting QB and he completed 17/28 passes for 131 passing yards, 1 touchdown, and 1 interception. J.K. Dobbins led the team in rushing yards with 36. Evan Engram led the receivers with 43 receiving yards on 4 receptions and 1 TD. Alex Singleton led the defense in that game with 16 solo tackles while Zach Allen led the defense in sacks with 2. Brandon Jones came away with the only interception for them in that one.

The current betting odds have the Broncos listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. The Broncos haven't looked good in their games this season with their 0-1 record overall so far. They haven't played any home games though and will be playing their home opener here. Meanwhile, the Jaguars have looked good in their games this season with their 1-0 record overall so far. They haven't played any road games yet and will be playing their 1st road game of the season here. The Jaguars looked great in week 1 with a 34-10 win over the Browns. They were up right away on the Browns and that game was over by halftime, but the Browns are also one of the worst teams in the NFL with a disaster situation at QB. Now the Jags are playing their 1st road game of the year and Denver has one of the biggest home advantages in the NFL. The Broncos looked terrible in their season opener with a 31-10 loss to the Chiefs, but they were one of the best teams in the NFL last season with one of the best defenses too. That defense didn't show up in week 1, but they are going to bounce back in this home opener and answer the call from last week. The offense was also terrible, but Bo Nix has been a feast or famine kind of QB in his short career and he will be looking to play better at home. The Jaguars also embarrassed the Broncos in Denver last season, so the Broncos will be coming for their revenge here. Look for the Broncos to bounce back here and pick up their 1st win of the season at home with the defense looking a lot better this week. The best way to place a bet here is on the Broncos to cover the spread in this game. 

Jaguars Broncos Prediction:  Our NFL Pick for Sunday, September 20, 2026 (4:05 pm ET start time) is Broncos 21 Jaguars 17.

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Jacksonville Jaguars: 22-12 ATS in all games. 10-5 ATS in road games. 17-7 ATS in all games where the total is between 42.5 and 49 points. 9-3 OVER in a road game where the total is between 42.5 and 49 points.

Denver Broncos: 1-4 ATS in the first two weeks of the regular season. 10-15 ATS at home against AFC South division opponents. 5-2 OVER as a home favorite of 7 points or less. 31-22 OVER after playing on Monday night football. 

Jacksonville Jaguars:  C. Braswell (CB) Injured - Knee. L. Allen Jr. (RB) Injured - Hip. J. Meyers (WR) Injured - Thumb. F. Oluokun (LB) Injured - Wrist. B. Thomas Jr. (WR) Injured - Shoulder. C. Van Lanen (OG) Injured - Knee.

Denver Broncos:  M. Mims Jr. (WR) Injured - Foot. J. Elliss (LB) Injured - Shoulder. T. Franklin (WR) Injured - Knee. R. Harvey (RB) Injured - Hamstring.

“It was awesome. Guys were ready to play.” - Trevor Lawrence after their win against the Browns in their last game. 

“Obviously not a good evening." - Sean Payton after his team’s loss against the Chiefs in their last game. 

WR Thomas Jr., Brian

WR Meyers, Jakobi

WR Washington, Parker

TE Strange, Brenton

QB Lawrence, Trevor

RB Tuten, Bhayshul 

WR Sutton, Courtland

WR Waddle, Jaylen

WR Bryant, Pat 

TE Engram, Evan

QB Nix, Bo

RB Dobbins, J.K.

Passing: Trevor Lawrence (245)

Rushing: Bhayshul Tuten (66)

Receiving: Parker Washington (83)

Touchdowns: Parker Washington (1)

Passing: Bo Nix (131)

Rushing: J.K. Dobbins (36)

Receiving: Evan Engram (43)

Touchdowns: Evan Engram (1)

Coaches:

Jacksonville Jaguars: Liam Coen (2nd season)

Denver Broncos: Sean Payton (4th season)