Jacksonville Jaguars vs Cincinnati Bengals Prediction, Preview and Odds - 09/14/2025

Game Time: 1:00 pm ET, Sunday, September 14, 2025

Venue:  Paycor Stadium, Cincinnati, OH

Where to Watch:  CBS

DraftKings:  Point Spread:  Jaguars +3.5, Bengals -3.5; Over/Under:  49.5 points

Bet365:  Point Spread:  Jaguars +3.5, Bengals -3.5; Over/Under:  49.5 points

BetMGM:  Point Spread:  Jaguars +3.5, Bengals -3.5; Over/Under:  49.5 points

Jacksonville Jaguars:  1-0 (2nd place, AFC South)

Cincinnati Bengals:  1-0 (1st place, AFC North)

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Jacksonville Jaguars:  won their last game at home against the Carolina Panthers 26-10.

Cincinnati Bengals:  won their last game on the road against the Cleveland Browns 17-16.

The Jaguars are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Carolina Panthers 26-10. Trevor Lawrence was the starting QB and he completed 19/31 passes for 178 passing yards, 1 touchdown, and 1 interception. Travis Etienne Jr. led the team in rushing yards with 143. Brenton Strange led the receivers with 59 receiving yards on 4 receptions. Foyesade Oluokun led the defense in that game with 6 solo tackles and 4 assisted tackles while Dawuane Smoot led the defense in sacks with 1. Foyesade Oluokun and Jourdan Lewis each came away with 1 interception for them in that one.

 

 

 

The Bengals are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Cleveland Browns 17-16. Joe Burrow was the starting QB and he completed 14/23 passes for 113 passing yards, 1 touchdown, and 0 interceptions. Chase Brown led the team in rushing yards with 43 and 1 TD. Tee Higgins led the receivers with 33 receiving yards on 3 receptions. Demetrius Knight Jr. led the defense in that game with 8 solo tackles and 2 assisted tackles while B.J. Hill and Trey Hendrickson each led the defense in sacks with 1. Jordan Battle and DJ Turner II each came away with 1 interception for them in that one.

The current betting odds have the Bengals listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The Bengals have a 1-0 record this season and they didn't look great in that season opener, but they got the win and looked a lot better in the opener than they did last season. The offense wasn't great as they only put up 17 points, but that will change with the talent they have on that offense. They had one of the worst defenses in the NFL last season, but that defense looked a lot better with their new DC. Meanwhile, the Jaguars have a 1-0 record this season and they looked good in their season opener, but they were also playing against one of the worst teams in the NFL. The defense looked really good as they weren't giving up much to the Panthers, but the offense has a lot more talent this season and still struggled to get going in that game against a Panthers defense that was one of the worst in the NFL last season. The Jaguars also have a new head coach which isn't ideal for Trevor Lawrence since this is now his 3rd head coach in his short NFL career. The Bengals offense wasn't clicking in week 1, but that was a tough defense on the road in a divisional game, they will look a lot better at home in this one while the Jags offense wasn't really tested last week and now has to go on the road. The best way to place a bet here is on the Bengals to cover the spread in this game. 

Jaguars Bengals Prediction:  Our NFL Pick for Sunday, September 14, 2025 (1:00 pm ET start time) is Bengals 24 Jaguars 20.

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Jacksonville Jaguars: 1-4 ATS against AFC North division opponents. 2-8 1H ATS as a road underdog. 4-10 1H ATS after playing a game at home. 4-1 OVER off a home win. 9-5 OVER after playing a game at home.

Cincinnati Bengals: 8-4 ATS as a favorite of 3.5 to 9.5 points. 4-0 ATS in all games where the total is greater than or equal to 49.5. 6-2 ATS off a road win. 4-1 OVER against AFC South division opponents. 8-3 OVER as a home favorite of 7 points or less. 

Jacksonville Jaguars:  None.

Cincinnati Bengals:  None.

“My boss gave it to me, so I had to accept. It's a cool moment for me personally and all that, but really it's about those guys. These guys played their tails off.” - Liam Coen on receiving a game ball after his team’s win against the Panthers in their last game. 

“For our guys just to find a way to win in the end. I’m proud of them. The best outcome of this game is 1-0. Forget about the stats. Forget about the score. Forget about how it all played out. The best the outcome could have been was 1-0 and we’re proud of that." - Zac Taylor after his team’s win against the Browns in their last game. 

WR Thomas Jr., Brian

WR Brown, Dyami

WR Hunter, Travis

TE Strange, Brenton

QB Lawrence, Trevor 

RB Etienne Jr., Travis

WR Chase, Ja'Marr

WR Higgins, Tee

WR Iosivas, Andrei

TE Sample, Drew

QB Burrow, Joe

RB Brown, Chase

Passing: T. Lawrence (178)

Rushing: T. Etienne Jr. (143)

Receiving: B. Strange (59)

Touchdowns: B. Thomas Jr. (1)

Passing: J. Burrow (113)

Rushing: C. Brown (43)

Receiving: T. Higgins (33)

Touchdowns: C. Brown (1)

Coaches:

Jacksonville Jaguars: Liam Coen (1st season)

Cincinnati Bengals: Zac Taylor (7th season)