Iowa State Cyclones vs Arkansas State Red Wolves Prediction, Picks and Game Preview - 09/13/2025

Game Time: 4:00 pm ET, Saturday, September 13, 2025

Venue:  Centennial Bank Stadium, Jonesboro, AR

Where to Watch:  ESPN2

DraftKings:  Point Spread:  ISU -21, AR State +21; Over/Under:  55.5 points

Bet365:  Point Spread:  ISU -21, AR State +21; Over/Under:  55 points

BetMGM:  Point Spread:  ISU -21, AR State +21; Over/Under:  55.5 points

Iowa State Cyclones:  3-0 (1-0) (1st place, Big 12)

Arkansas State Red Wolves:  1-1 (0-0) (3rd place, Sun Belt West)

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Iowa State Cyclones:  won their last game at home against the Iowa Hawkeyes 16-13.

Arkansas State Red Wolves:  lost their last game on the road against the Arkansas Razorbacks 56-14.

Iowa State is entering this game with a 3-0 record overall and they have a 1-0 record in their conference games too. They are 2-0 in their home games, 0-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Iowa 16-13. Rocco Becht was the starting QB and he completed 18/27 passes for 134 passing yards, 1 touchdown, and 0 interceptions. Abu Sama III led the team in rushing yards with 47. Brett Eskildsen led the receivers with 39 receiving yards on 2 receptions. Marcus Neal led the defense in that game with 5 solo tackles and 4 assisted tackles while Tamatoa McDonough led the defense in sacks with 2. Jeremiah Cooper came away with the only interception for them in that one.

 

 

 

Arkansas State is entering this game with a 1-1 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Arkansas 56-14. Jaylen Raynor was the starting QB and he completed 21/33 passes for 125 passing yards, 1 touchdown, and 2 interceptions. Jaylen Raynor led the team in rushing yards with 38. Chauncy Cobb led the receivers with 50 receiving yards on 4 receptions. Terry Kirksey Jr. led the defense in that game with 5 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Terry Kirksey Jr. and Avante Dickerson each came away with 1 interception for them in that one.

The current betting odds have Iowa State listed as a 21 point favorite in this game according to Draftkings Sportsbook. Iowa State has a 3-0 record overall this season and they have looked great in their games so far. They have been tested already with a tough rivalry game, beating Iowa 16-13 last week, and they are also 1-0 in conference games with a win over Kansas State in week 1. They have played 2 home games so far, but they also have a neutral site conference game in Ireland under their belt so this road game is going to be no problem for them against a weaker opponent too. They have very high hopes this season of being a true threat to win the Big 12 and they are going to be motivated to keep powering forward, using this game as a tune up after a slugfest against their rival last week. Meanwhile, Arkansas State has a 1-1 record overall and they don't have the talent to compete with these power 4 schools. They beat up on a team from the FCS in week 1, but their defense didn't look great as they still gave up 24 points. Now they are off a 56-14 road loss to Arkansas where their defense looked terrible again, and being at home here isn't going to help them much. Iowa State has been rolling in their games and they have an extra game under their belt too so a team like Arkansas State isn't going to be able to slow them down here. The best way to place a bet here is on Iowa State to cover the spread in this game. 

Iowa State Arkansas State Prediction:  Our NCAAF Pick for Saturday, September 13, 2025 (4:00 pm ET start time) is Iowa State 45 Arkansas State 17.

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Iowa State Cyclones: 7-3 ATS in road lined games. 6-2 ATS after allowing 14 points or less last game. 7-4 ATS in games played on turf. 7-4 UNDER when the total is between 49.5 and 56. 

Arkansas State Red Wolves: 1-5 ATS as an underdog of 10.5 to 21 points. 19-31 ATS vs. good offensive  teams - scoring 31 or more points/game. 3-7 ATS vs. good defensive teams who give up 17 or less points/game. 20-8 UNDER as a home underdog.

Iowa State Cyclones:  M. Chapman (DL) Questionable - Undisclosed. T. Buhr (OG) Questionable - Illness. W. Archer (CB) Questionable - Undisclosed. C. Willich (LB) Questionable - Undisclosed. D. Hasert (OG) Questionable - Undisclosed. D. Jackson (WR) Questionable - Undisclosed. L. Hicks II (CB) Questionable - Undisclosed. R. Peppers (RB) Questionable - Undisclosed. S. Zelenovich (WR) Questionable - Undisclosed. J. Klosterman (LB) Questionable - Undisclosed. J. Jackson (RB) Questionable - Undisclosed. W. Tompkins (OG) Questionable - Undisclosed. D. Jensen (OG) Questionable - Undisclosed. S. Same (LB) Questionable - Undisclosed. M. Parkes (WR) Questionable - Undisclosed. M. Sat (OG) Questionable - Undisclosed. E. Stecker (CB) Questionable - Undisclosed.

Arkansas State Red Wolves:  J. Cross (RB) Out - Knee.

“You win football games when your best players make the best plays in key moments. When you've got a guy like Kyle, you just trust him.” - Matt Campbell after his team’s win against Iowa in their last game. 

“When you play a team like Arkansas, they will expose you. If your eyes are in the wrong place, if you don’t use the proper technique or fundamentals and details to execute, you’re going to be behind, and the speed of the game is going to get you and the size of the game is going to get you. That was the case, particularly the way we started.” - Butch Jones after his team’s loss against Arkansas in their last game. 

WR Overby, Dominic

WR Eskildsen, Brett

WR Green, Eli

TE Burkle, Gabe

TE Brahmer, Benjamin

QB Becht, Rocco

RB Hansen, Carson

WR Rucker, Corey

WR Summers, Hunter

WR Cobb, Chauncy

TE Little, Tyler

QB Raynor, Jaylen

RB Cross, Ja'Quez

Passing: R. Becht (595)

Rushing: C. Hansen (136)

Receiving: B. Eskildsen (162)

Touchdowns: B. Brahmer (3)

Passing: J. Raynor (470)

Rushing: D. Spencer (73)

Receiving: C. Cobb (135)

Touchdowns: J. Cross (2)

Coaches:

Iowa State Cyclones: Matt Campbell (10th season)

Arkansas State Red Wolves: Butch Jones (5th season)