Iowa State Cyclones vs Arizona Wildcats Prediction, Picks and Game Preview - 10/24/2026

Game Time: 7:30 pm ET, Saturday, October 24, 2026

Venue:  Arizona Stadium, Tucson, AZ

Where to Watch:  ESPN2

DraftKings:  Point Spread:  Iowa State +10, Arizona -10; Over/Under:  50.5 points

Bet365:  Point Spread:  Iowa State +10, Arizona -10; Over/Under:  50.5 points

BetMGM:  Point Spread:  Iowa State +10, Arizona -10; Over/Under:  50.5 points

Iowa State Cyclones:  3-3 (1-2) (12th place, Big 12)

Arizona Wildcats:  5-1 (2-1) (5th place, Big 12)

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Iowa State Cyclones:  lost their last game on the road against the BYU Cougars 24-10.

Arizona Wildcats:  won their last game on the road against the West Virginia Mountaineers 52-31.

Iowa State is entering this game with a 3-3 record overall and they have a 1-2 record in their conference games too. They are 3-1 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against BYU 24-10. Jaylen Raynor was the starting QB and he completed 16/29 passes for 98 passing yards, 1 touchdown, and 0 interceptions. Aiden Flora led the team in rushing yards with 86. Tyler Claiborne led the receivers with 31 receiving yards on 3 receptions. Sullivan Schlimgen led the defense in that game with 10 tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

Arizona is entering this game with a 5-1 record overall and they have a 2-1 record in their conference games too. They are 3-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against West Virginia 52-31. Noah Fifita was the starting QB and he completed 16/23 passes for 341 passing yards, 3 touchdowns, and 1 interception. Antwan Roberts led the team in rushing yards with 63 and 1 TD. Isaiah Mizell led the receivers with 183 receiving yards on 6 receptions and 2 TDs. Cam Chapa led the defense in that game with 15 tackles while Julian Savaiinaea led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Arizona listed as a 10 point favorite in this game according to Draftkings Sportsbook. Arizona has looked really good in their games this season with their 5-1 record overall and their 2-1 conference record which has them right near the top of the Big 12. They have looked great on their home field too with their 3-0 home record this season. Meanwhile, Iowa State hasn't looked great in their games this season with their 3-3 record overall and their 1-2 conference record which has them in the bottom half of the Big 12. They have been a bad road team too with their 0-2 road record this year. Iowa State has had a tough schedule lately and they are coming off a 24-10 loss to BYU in their last one. They are coming out of their bye week now, but that isn't going to help much. Their defense hasn't looked great all season, giving up a lot of points in their games, and their offense has had a lot more trouble in conference play as they have played against tougher defenses. Arizona has been quietly rolling this season and they are starting to look like one of the best teams in the Big 12 now. Their defense hasn't looked that great, but their offense has and they have been putting up a ton of points in their games lately. They are coming off a 52-31 road win over West Virginia in their last one and they went right into their bye week after that, so they are going to be well rested for this game too. Their only loss this season was a road loss to BYU who just pulled off an upset win over Notre Dame, and that was a tight game for most of the time, so Arizona has the talent to compete in this conference. Iowa State is starting to fade away now after a scrappy start to the season, so look for Arizona to roll over them at home. The best way to place a bet here is on Arizona to cover the spread in this game. 

Iowa State Arizona Prediction:  Our NCAAF Pick for Saturday, October 24, 2026 (7:30 pm ET start time) is Arizona 38 Iowa State 17.

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Iowa State Cyclones: 6-3 ATS after playing their last game on the road. 5-2 ATS on the road as an underdog. 3-1 ATS on the road versus good offensive teams - averaging 425 yards/game or more. 38-26 UNDER as an underdog of 3.5 to 10 points. 38-26 UNDER off a road loss against a conference rival.

Arizona Wildcats: 25-45 ATS as a favorite of 3.5 to 10 points. 16-24 ATS in a home game where the total is between 49.5 and 56. 19-30 ATS after 3 or more consecutive straight up wins. 24-16 UNDER in a home game where the total is between 49.5 and 56. 9-3 UNDER after playing their last game on the road.

Iowa State Cyclones:  D. Overby (WR) Questionable - Knee. E. Miller (RB) Questionable - Undisclosed. L. Galer (TE) Questionable - Undisclosed. J. Singletary (CB) Questionable - Undisclosed. C. Crawford (DL) Questionable - Undisclosed. R. Barnes (TE) Questionable - Undisclosed. C. Pabst (WR) Out - Knee. J. Bailey (WR) Out - Undisclosed.

Arizona Wildcats:  S. Brennan (WR) Questionable - Undisclosed. C. Warren III (RB) Questionable - Undisclosed. G. Richardson (WR) Questionable - Hamstring. C. Rusk (TE) Questionable - Leg. M. Harris (LB) Questionable - Undisclosed. T. Spivey (WR) Out - Ankle. D. Austin (S) Out - Undisclosed.

“I’m kind of at a loss of words because I felt like we were going to come into this and be competitive in so many ways, and we really weren’t in so many ways. 3-3 is where we’re at. Doesn’t mean that that’s where we need to be.” - Jimmy Rogers after his team’s loss against BYU in their last game. 

“Holy smokes, Isaiah Mizell. I'm really proud of him. He was going to be ready for his opportunity.” - Brent Brennan after his team’s win against WVU in their last game. 

WR Overby, Dominic

WR Jackson, Cody

WR Hayes, Omari

TE Fortenberry, Tyler

QB Raynor, Jaylen

RB Flora, Aiden

WR Spivey, Tré

WR Hunter III, Chris

WR Richardson, Giovanni

TE Rusk, Cole

QB Fifita, Noah

RB Mahdi, Ismail

Passing: Jaylen Raynor (1,001)

Rushing: Aiden Flora (680)

Receiving: Dominic Overby (212)

Touchdowns: Aiden Flora (6)

Passing: Noah Fifita (1,756)

Rushing: Kedrick Reescano (262)

Receiving: Isaiah Mizell (359)

Touchdowns: Kedrick Reescano (4)

Coaches:

Iowa State Cyclones: Jimmy Rogers (1st season)

Arizona Wildcats: Brent Brennan (3rd season)