Iowa Hawkeyes vs USC Trojans Prediction, Picks and Game Preview - 11/15/2025

Game Time: 3:30 pm ET, Saturday, November 15, 2025

Venue:  LA Memorial Coliseum, Los Angeles, CA

Where to Watch:  Big Ten Network

DraftKings:  Point Spread:  Iowa +6.5, USC -6.5; Over/Under:  49.5 points

Bet365:  Point Spread:  Iowa +6.5, USC -6.5; Over/Under:  49.5 points

BetMGM:  Point Spread:  Iowa +6.5, USC -6.5; Over/Under:  49.5 points

Iowa Hawkeyes:  6-3 (4-2) (6th place, Big Ten)

USC Trojans:  7-2 (5-1) (4th place, Big Ten)

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Iowa Hawkeyes:  lost their last game at home against the Oregon Ducks 18-16.

USC Trojans:  won their last game at home against the Northwestern Wildcats 38-17.

Iowa is entering this game with a 6-3 record overall and they have a 4-2 record in their conference games too. They are 4-2 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Oregon 18-16. Mark Gronowski was the starting QB and he completed 10/18 passes for 138 passing yards, 1 touchdown, and 0 interceptions. Kamari Moulton led the team in rushing yards with 87. DJ Vonnahme led the receivers with 43 receiving yards on 2 receptions and 1 TD. Jayden Montgomery led the defense in that game with 5 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Deshaun Lee came away with the only interception for them in that one.

 

 

 

USC is entering this game with a 7-2 record overall and they have a 5-1 record in their conference games too. They are 5-0 in their home games, 2-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Northwestern 38-17. Jayden Maiava was the starting QB and he completed 24/33 passes for 299 passing yards, 2 touchdowns, and 1 interception. King Miller led the team in rushing yards with 127 and 1 TD. Makai Lemon led the receivers with 161 receiving yards on 11 receptions and 1 TD. Kamari Ramsey led the defense in that game with 5 solo tackles and 1 assisted tackle while Jide Abasiri and Jahkeem Stewart each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Iowa listed as a 6.5 point underdog in this game according to Draftkings Sportsbook. Iowa has looked good in their games this season with their 6-3 record overall and their 4-2 conference record which has them in the top half of the Big Ten. They are off an 18-16 loss at home to Oregon in their last one, but they looked good in that game against a top 10 team in the nation and they are still trying to make a playoff case for themselves. Meanwhile, USC has looked really good in their games this season with their 7-2 record overall and their 5-1 conference record which has them right near the top of the Big Ten. They have looked a lot better on their home field this year with their 5-0 home record and they are still trying to make a playoff case for themselves too. They are off a 38-17 win over Northwestern in their last one and they haven't really been challenged in their home games this year, but this is going to be one of the best defenses they play all season and that Iowa defense is going to travel. Iowa is going to muddy this game up with their defense like they usually do and USC still doesn't have a great defense themselves so Iowa will be able to move the ball. Iowa was very close to beating Oregon in their last one too so they are only going to be more motivated here to pick up a road ranked win. The best way to place a bet here is on USC to cover the spread in this game. 

Iowa USC Prediction:  Our NCAAF Pick for Saturday, November 15, 2025 (3:30 pm ET start time) is USC 23 Iowa 20.

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Iowa Hawkeyes: 7-4 ATS in road lined games. 5-2 ATS vs. good passing teams averaging 8 or more passing yards/att. 9-5 ATS when playing against a team with a winning record. 6-3 OVER after 1 or more consecutive straight up losses. 

USC Trojans: 2-8 ATS as a favorite of 3.5 to 10 points. 4-10 ATS after scoring 37 points or more last game. 3-10 ATS off a win against a conference rival. 10-5 OVER as a home favorite. 6-1 OVER in a home game where the total is between 49.5 and 56. 

Iowa Hawkeyes:  J. Buie (WR) Questionable - Undisclosed. L. Allgeyer (OG) Questionable - Undisclosed. A. Ostrenga (TE) Out - Undisclosed.

USC Trojans:  D. Harvey (CB) Questionable - Undisclosed. J. Jarrett (DL) Questionable - Undisclosed. W. Jordan (RB) Questionable - Ankle. A. Beavers Jr. (LB) Questionable - Undisclosed. P. Brown (CB) Questionable - Undisclosed. F. Boucard (DL) Questionable - Undisclosed. C. Chittenden (K) Questionable - Undisclosed. E. Sanders (RB) Out - Knee. C. Johnson (CB) Out - Knee.

“Sometimes that’s football. When you play a team like Oregon, you’ve got to be right there. There’s nothing easy. This was a game we were hoping it could be. And we couldn’t get it done.” - Kirk Ferentz after his team’s loss against Oregon in their last game. 

“We were excited about the challenge that this became. Flipping time zones, the tough battle in Lincoln just a few days ago, and then having to turn over and play a really good football team coming off a bye week. I just felt like these last two games would be a really important stretch for this season, and it’s cool to see our guys respond.” - Lincoln Riley after his team’s win against Northwestern in their last game. 

WR Phillips, Sam

WR Anderson, Seth 

WR Gill, Jacob

TE Large, Hayden

QB Gronowski, Mark

RB Moulton, Kamari

WR Lane, Ja'Kobi

WR Hines, Tanook

WR Lemon, Makai

TE McRee, Lake

QB Maiava, Jayden

RB Miller, King

Passing: Mark Gronowski (1,084)

Rushing: Kamari Moulton (522)

Receiving: Sam Phillips (216)

Touchdowns: Mark Gronowski (12)

Passing: Jayden Maiava (2,614)

Rushing: King Miller (636)

Receiving: Makai Lemon (937)

Touchdowns: Makai Lemon (9)

Coaches:

Iowa Hawkeyes: Kirk Ferentz (27th season)

USC Trojans: Lincoln Riley (4th season)