by Rod Pearson
Monday, Sep 01, 2025
Game Time: 12:00 pm ET, Saturday, September 6, 2025
Venue: Jack Trice Stadium, Ames, IA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Iowa +3, ISU -3; Over/Under: 41.5 points
Bet365: Point Spread: Iowa +3, ISU -3; Over/Under: 41.5 points
BetMGM: Point Spread: Iowa +3, ISU -3; Over/Under: 41.5 points
Season Record
Iowa Hawkeyes: 1-0 (0-0) (7th place, Big Ten)
Iowa State Cyclones: 2-0 (1-0) (1st place, Big 12)
Do not miss out on our expert handicapper analysis! Big Al McMordie is on a HOT STREAK in college football on a 97-64-2 CFB RUN for +$26,970 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Iowa Hawkeyes: won their last game at home against the Albany Great Danes 34-7.
Iowa State Cyclones: won their last game at home against the South Dakota Coyotes 55-7.
Iowa Hawkeyes vs Iowa State Cyclones Preview and Analysis
Iowa is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Albany 34-7. Mark Gronowski was the starting QB and he completed 8/15 passes for 44 passing yards, 1 touchdown, and 0 interceptions. Xavier Williams led the team in rushing yards with 122 and 1 TD. Jacob Gill led the receivers with 13 receiving yards on 1 reception. TJ Hall led the defense in that game with 5 solo tackles and 0 assisted tackles while Aaron Graves and Max Llewellyn each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Iowa State is entering this game with a 2-0 record overall and they have a 1-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against South Dakota 55-7. Rocco Becht was the starting QB and he completed 19/20 passes for 278 passing yards, 3 touchdowns, and 0 interceptions. Dylan Lee led the team in rushing yards with 81 and 1 TD. Gabe Burkle led the receivers with 85 receiving yards on 4 receptions and 1 TD. Jamison Patton led the defense in that game with 4 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Jamison Patton and Nick Reinicke each came away with 1 interception for them in that one.
Iowa vs Iowa State Prediction
The current betting odds have Iowa State listed as a 3 point favorite in this game according to Draftkings Sportsbook. Iowa State has looked great in their games this season with their 2-0 record overall and their 1-0 conference record. They opened the season with a tough conference game in Ireland, but they managed to get the win and then come back home in week 1 to play one of the best FCS teams from last season, and they embarrassed them. They won 55-7 against South Dakota and they look like they are picking up right where they left off last season as a true contender in the Big 12. They also have a big advantage here since they have 2 games under their belt while Iowa only has 1 game played and it was against a team from the FCS so they weren't really challenged in that one. Iowa ended up beating Albany 34-7 in their season opener, but it took them a while to get going and pull away in that game. They didn't have a great passing game either with their starting QB only throwing for 44 yards. They look like they are ready to play another season of Iowa football with great defense and a solid running game, but this is a much stronger Iowa State team than they have faced in years past and they could get themselves into a lot of trouble with that terrible passing game if they fall too far behind here. Iowa always makes this a close game, but Iowa State looks like the more well-rounded team and they have the home advantage too. The best way to place a bet here is on Iowa State to cover the spread in this game.
Iowa Iowa State Prediction: Our NCAAF Pick for Saturday, September 6, 2025 (12:00 pm ET start time) is Iowa State 24 Iowa 10.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Iowa Hawkeyes Iowa State Cyclones prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.
NCAAF Betting Trends
Iowa Hawkeyes: 2-5 ATS as an underdog. 3-6 ATS in non-conference games. 2-6 ATS after a win by 17 or more points. 6-1 UNDER as an underdog. 12-4 UNDER after allowing 14 points or less last game.
Iowa State Cyclones: 4-1 ATS as a home favorite of 7 points or less. 5-1 ATS when the total is between 35.5 and 42 points. 6-2 ATS after allowing 14 points or less last game. 9-5 UNDER in home lined games. 4-1 UNDER after scoring 37 points or more last game.
Key Injuries
Iowa Hawkeyes: K. Moulton (RB) Questionable - Undisclosed. R. Vander Zee (WR) Questionable - Foot. J. Buie (WR) Questionable - Undisclosed.
Iowa State Cyclones: T. Buhr (OG) Questionable - Illness. D. Hasert (OG) Questionable - Undisclosed. D. Jackson (WR) Questionable - Undisclosed. M. Chapman (DL) Out - Undisclosed. L. Hicks II (CB) Questionable - Undisclosed. R. Peppers (RB) Questionable - Undisclosed. S. Zelenovich (WR) Questionable - Undisclosed. J. Klosterman (LB) Questionable - Undisclosed. J. Jackson (RB) Questionable - Undisclosed. W. Tompkins (OG) Questionable - Undisclosed. D. Jensen (OG) Questionable - Undisclosed. S. Same (LB) Questionable - Undisclosed. M. Parkes (WR) Questionable - Undisclosed. M. Sat (OG) Questionable - Undisclosed. E. Stecker (CB) Questionable - Undisclosed.
Notable Quotes
“It was just good to get the win. That's what we came for.” - Kirk Ferentz after his team’s win against Albany in their last game.
“He’s a young man for us that just continues to do great things in a powerful way. I told him, ‘You just have to go out there and win,’ and he felt really good about it.” - Matt Campbell after his team’s win against South Dakota in their last game.
Starting Lineups
Iowa Hawkeyes
WR Phillips, Sam
WR Gill, Jacob
WR Anderson, Seth
TE Ostrenga, Addison
QB Gronowski, Mark
RB Moulton, Kamari
Iowa State Cyclones
WR Overby, Dominic
WR Eskildsen, Brett
WR Green, Eli
TE Burkle, Gabe
TE Brahmer, Benjamin
QB Becht, Rocco
RB Hansen, Carson
Statistical Leaders
Iowa Hawkeyes
Passing: M. Gronowski (44)
Rushing: X. Williams (122)
Receiving: J. Gill (13)
Touchdowns: M. Gronowski (1)
Iowa State Cyclones
Passing: R. Becht (461)
Rushing: C. Hansen (90)
Receiving: B. Eskildsen (123)
Touchdowns: B. Brahmer (2)
Coaches:
Iowa Hawkeyes: Kirk Ferentz (27th season)
Iowa State Cyclones: Matt Campbell (10th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
