by Rod Pearson
Tuesday, Sep 16, 2025
Game Time: 1:00 pm ET, Sunday, September 21, 2025
Venue: Nissan Stadium, Nashville, TN
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Colts -3.5, Titans +3.5; Over/Under: 43.5 points
Bet365: Point Spread: Colts -3.5, Titans +3.5; Over/Under: 43.5 points
BetMGM: Point Spread: Colts -3.5, Titans +3.5; Over/Under: 43.5 points
Season Record
Indianapolis Colts: 2-0 (1st place, AFC South)
Tennessee Titans: 0-2 (4th place, AFC South)
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Recent Form
Indianapolis Colts: won their last game at home against the Denver Broncos 29-28.
Tennessee Titans: lost their last game at home against the Los Angeles Rams 33-19.
Indianapolis Colts vs Tennessee Titans Preview and Analysis
The Colts are entering this game with a 2-0 record overall and they have a 0-0 record in their divisional games too. They are 2-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Denver Broncos 29-28. Daniel Jones was the starting QB and he completed 23/34 passes for 316 passing yards, 1 touchdown, and 0 interceptions. Jonathan Taylor led the team in rushing yards with 165. Tyler Warren led the receivers with 79 receiving yards on 4 receptions. Nick Cross led the defense in that game with 5 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Camryn Bynum came away with the only interception for them in that one.
The Titans are entering this game with a 0-2 record overall and they have a 0-0 record in their divisional games too. They are 0-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Los Angeles Rams 33-19. Cameron Ward was the starting QB and he completed 19/33 passes for 175 passing yards, 1 touchdown, and 0 interceptions. Tony Pollard led the team in rushing yards with 92. Calvin Ridley led the receivers with 57 receiving yards on 3 receptions. Amani Hooker and Jarvis Brownlee Jr. each led the defense in that game with 5 solo tackles and 3 assisted tackles while Amani Hooker led the defense in sacks with 1. Cody Barton came away with the only interception for them in that one.
Colts vs Titans Prediction
The current betting odds have the Colts listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The Colts have looked great in their games this season with their 2-0 record overall which has them right at the top of the AFC South. They beat up on a really bad Dolphins team in week 1, obliterating them 33-8, but now they are off a really good win over the Broncos 29-28. They were trailing for most of that game, but they also put up 29 points against one of the best defenses in the NFL as Daniel Jones has looked great in this new offense. Now they are playing their first road game of the season and it is a divisional game too, but they are playing one of the worst teams in the NFL who has been struggling to start the season. Meanwhile, the Titans have a 0-2 record overall this season and they haven't looked good in their games. They kept their week 1 game with the Broncos really close on the road, never trailing by more than 1 score in that one, but they came home and got obliterated by the Rams 33-19. They don't have a bad defense so they have been staying competitive in games and they were right in that game against the Rams up until halftime. They let the game get away from them in the 2nd half though and that is because they just don't have a good offense. Cam Ward has shown some flashes that he can be the guy, but he is not ready to go yet in this rookie season so this offense is going to need some time to get on the same page. The Colts have a much better offense that will eventually pull away in this one. The best way to place a bet here is on the Colts to cover the spread in this game.
Colts Titans Prediction: Our NFL Pick for Sunday, September 21, 2025 (1:00 pm ET start time) is Colts 27 Titans 9.
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NFL Betting Trends
Indianapolis Colts: 9-5 ATS as a favorite. 17-9 ATS against conference opponents. 8-4 ATS versus division opponents. 8-4 OVER versus division opponents. 6-3 OVER off a home win.
Tennessee Titans: 10-25 ATS in all games. 3-13 ATS as an underdog of 3.5 to 9.5 points. 2-10 ATS versus division opponents. 3-10 ATS after playing a game at home. 7-2 OVER off a home loss. 10-4 OVER after 2 or more consecutive losses.
Key Injuries
Indianapolis Colts: A. Ajiake (LB) Injured - Throat. J. Downs (WR) Injured - Ankle. T. Goodson (RB) Injured - Elbow. L. Latu (DL) Injured - Hamstring. B. Raimann (OT) Injured - Illness. C. Ward (CB) Injured - Concussion. T. Warren (TE) Injured - Toe.
Tennessee Titans: J. Latham (OT) Injured - Hip. K. Mullings (RB) Injured - Ankle. B. Oliver (WR) Injured - Knee. L. Sneed (CB) Injured - Back. T. Sweat (DL) Injured - Ankle. K. Winston Jr. (S) Injured - Hamstring. K. Zeitler (OG) Injured - Bicep.
Notable Quotes
“It's electric in there right now. To win a game like that — Spencer did a hell of a job finishing it there with the kick. We found a way to do it.” - Shane Steichen after his team’s win against the Broncos in their last game.
“Frustrating to start a season 0-2, certainly. I’ve still got a lot of belief in our football team, that we can win games in this league in the season. But right now, we haven’t put together a game worth winning against two really good football teams to start.” - Brian Callahan after his team’s loss against the LA Rams in their last game.
Starting Lineups
Indianapolis Colts
WR Pittman Jr., Michael
WR Pierce, Alec
WR Downs, Josh
TE Warren, Tyler
QB Jones, Daniel
RB Taylor, Jonathan
Tennessee Titans
WR Ayomanor, Elic
WR Ridley, Calvin
WR Lockett, Tyler
TE Okonkwo, Chig
QB Ward, Cam
RB Pollard, Tony
Statistical Leaders
Indianapolis Colts
Passing: D. Jones (588)
Rushing: J. Taylor (236)
Receiving: T. Warren (155)
Touchdowns: D. Jones (3)
Tennessee Titans
Passing: C. Ward (287)
Rushing: T. Pollard (152)
Receiving: C. Ridley (84)
Touchdowns: E. Ayomanor (1)
Coaches:
Indianapolis Colts: Shane Steichen (3rd season)
Tennessee Titans: Brian Callahan (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
