by Rod Pearson
Thursday, Sep 25, 2025
Game Time: 4:05 pm ET, Sunday, September 28, 2025
Venue: SoFi Stadium, Inglewood, CA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Colts +3.5, Rams -3.5; Over/Under: 49.5 points
Bet365: Point Spread: Colts +3.5, Rams -3.5; Over/Under: 49.5 points
BetMGM: Point Spread: Colts +3.5, Rams -3.5; Over/Under: 49.5 points
Season Record
Indianapolis Colts: 3-0 (1st place, AFC South)
Los Angeles Rams: 2-1 (4th place, NFC West)
Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the NFL on a 19-11-1 NFL RUN for +$7,020 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Indianapolis Colts: won their last game on the road against the Tennessee Titans 41-20.
Los Angeles Rams: lost their last game on the road against the Philadelphia Eagles 33-26.
Indianapolis Colts vs Los Angeles Rams Preview and Analysis
The Colts are entering this game with a 3-0 record overall and they have a 1-0 record in their divisional games too. They are 2-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Tennessee Titans 41-20. Daniel Jones was the starting QB and he completed 18/25 passes for 228 passing yards, 1 touchdown, and 0 interceptions. Jonathan Taylor led the team in rushing yards with 102 and 3 TDs. Michael Pittman Jr. led the receivers with 73 receiving yards on 6 receptions and 1 TD. Nick Cross led the defense in that game with 5 solo tackles and 2 assisted tackles while Tyquan Lewis led the defense in sacks with 2. Kenny Moore II came away with the only interception for them in that one.
The Rams are entering this game with a 2-1 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Philadelphia Eagles 33-26. Matthew Stafford was the starting QB and he completed 19/33 passes for 196 passing yards, 2 touchdowns, and 1 interception. Kyren Williams led the team in rushing yards with 94. Puka Nacua led the receivers with 112 receiving yards on 11 receptions. Kamren Curl led the defense in that game with 6 solo tackles and 3 assisted tackles while Byron Young, Jared Verse, Poona Ford, and Jaylen McCollough each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Colts vs Rams Prediction
The current betting odds have the Rams listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The Rams have looked good in their games this season with their 2-1 record overall, and they were really close to being 3-0 last week. They are off a 33-26 loss to the Eagles in their last one, but they had the Eagles beat in that game and let them back in it in the 2nd half. They ended up losing on a blocked FG that could have won the Rams the game, but their offense also struggled to get the ball in the end zone throughout the game. Meanwhile, the Colts have looked great in their games this season with their 3-0 record overall which has them right at the top of the AFC South. They have looked great in their 3 games, but 2 of those wins also came against bad teams, beating the Dolphins and the Titans. They do have a solid win at home over the Broncos, but they barely won that game on a last second FG and now they travel to the West coast for their strongest opponent yet. The Colts have looked great, but they have been overachieving to start the season and the Rams are going to be looking to bounce back at home after the way they lost that game in Philadelphia. The Rams have also looked a lot better in their last 2 games and they have the talent to show the Colts what a real Super Bowl contender looks like. The best way to place a bet here is on the Rams to cover the spread in this game.
Colts Rams Prediction: Our NFL Pick for Sunday, September 28, 2025 (4:05 pm ET start time) is Rams 27 Colts 20.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Indianapolis Colts Los Angeles Rams prediction, be sure to drop by every day for our weekly NFL predictions and previews.
NFL Betting Trends
Indianapolis Colts: 3-7 ATS in non-conference games. 0-4 ATS vs. good passing teams averaging 235 or more passing yards/game. 0-3 ATS vs. good offensive teams - scoring 24 or more points/game. 22-14 OVER in all games. 19-10 OVER in games played on turf.
Los Angeles Rams: 23-15 ATS in all games. 12-6 ATS as a favorite. 8-4 ATS vs. good offensive teams - scoring 24 or more points/game. 6-0 OVER vs. good passing defenses - allowing 5.7 or less passing yards/att. 7-1 OVER vs. good teams - outscoring opponents by 6+ PPG on the season.
Key Injuries
Indianapolis Colts: D. Buckner (DL) Injured - Back. M. Goncalves (OG) Injured - Toe. X. Howard (CB) Injured - Rest. K. Moore II (CB) Injured - Achilles. A. Pierce (WR) Injured - Concussion. R. Sanchez (P) Injured - Personal.
Los Angeles Rams: D. Adams (WR) Injured - Hamstring. R. Havenstein (OG) Injured - Ankle. C. Parkinson (TE) Injured - Shoulder. S. Avila (OG) Injured - Ankle. B. Fiske (DL) Injured - Oblique. K. Kinchens (S) Injured - Shoulder. J. Dedich (OG) Injured - Chest.
Notable Quotes
“We all were on the headsets like, we punted, shoot!' Because we thought we had the penalty. And so we’re like, ‘Oh, we’ve still got it going.’ And then we had to punt there.” - Shane Steichen after his team’s win against the Titans in their last game.
“I mean, we’ve all been a part of enough NFL games that the scoreboard doesn’t really matter until the end of the game. We had our chance at the end of the game and it didn’t go our way.” - Matt Stafford after their loss against the Eagles in their last game.
Starting Lineups
Indianapolis Colts
WR Pittman Jr., Michael
WR Pierce, Alec
WR Downs, Josh
TE Warren, Tyler
QB Jones, Daniel
RB Taylor, Jonathan
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Whittington, Jordan
TE Higbee, Tyler
QB Stafford, Matthew
RB Williams, Kyren
Statistical Leaders
Indianapolis Colts
Passing: Daniel Jones (816)
Rushing: Jonathan Taylor (338)
Receiving: Tyler Warren (193)
Touchdowns: Jonathan Taylor (4)
Los Angeles Rams
Passing: Matthew Stafford (739)
Rushing: Kyren Williams (226)
Receiving: Puka Nacua (333)
Touchdowns: Davante Adams (2)
Coaches:
Indianapolis Colts: Shane Steichen (3rd season)
Los Angeles Rams: Sean McVay (9th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
