by Rod Pearson
Friday, Oct 17, 2025
Game Time: 4:05 pm ET, Sunday, October 19, 2025
Venue: SoFi Stadium, Inglewood, CA
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Colts +1.5, Chargers -1.5; Over/Under: 48.5 points
Bet365: Point Spread: Colts +1.5, Chargers -1.5; Over/Under: 48.5 points
BetMGM: Point Spread: Colts +1.5, Chargers -1.5; Over/Under: 48.5 points
Season Record
Indianapolis Colts: 5-1 (1st place, AFC South)
Los Angeles Chargers: 4-2 (1st place, AFC West)
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Recent Form
Indianapolis Colts: won their last game at home against Arizona Cardinals 31-27.
Los Angeles Chargers: won their last game on the road against the Miami Dolphins 29-27.
Indianapolis Colts vs Los Angeles Chargers Preview and Analysis
The Colts are entering this game with a 5-1 record overall and they have a 1-0 record in their divisional games too. They are 4-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Arizona Cardinals 31-27. Daniel Jones was the starting QB and he completed 22/30 passes for 212 passing yards, 2 touchdowns, and 1 interception. Jonathan Taylor led the team in rushing yards with 123 and 1 TD. Tyler Warren led the receivers with 63 receiving yards on 6 receptions and 1 TD. Germaine Pratt led the defense in that game with 8 solo tackles and 3 assisted tackles while Kwity Paye led the defense in sacks with 2. Mekhi Blackmon came away with the only interception for them in that one.
The Chargers are entering this game with a 4-2 record overall and they have a 3-0 record in their divisional games too. They are 1-1 in their home games, 2-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Miami Dolphins 29-27. Justin Herbert was the starting QB and he completed 29/38 passes for 264 passing yards, 2 touchdowns, and 0 interceptions. Kimani Vidal led the team in rushing yards with 124. Ladd McConkey led the receivers with 100 receiving yards on 7 receptions and 1 TD. Troy Dye led the defense in that game with 5 solo tackles and 1 assisted tackle while Odafe Oweh and Tuli Tuipulotu each led the defense in sacks with 1. Tony Jefferson, Derwin James Jr., and Benjamin St-Juste each came away with 1 interception for them in that one.
Colts vs Chargers Prediction
The current betting odds have the Chargers listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Chargers have looked good in their games this season with their 4-2 record overall which has them right near the top of the AFC West. They went through a rough patch after starting the season 3-0, but they bounced back in their last one with a nice win over the Dolphins. Their offense looked a lot better in that win too. Meanwhile, the Colts have looked great in their games this season with their 5-1 record overall which has them right at the top of the AFC South. They have been a big surprise this season as Daniel Jones is reviving his career, but they are due to start coming back down to Earth now. They are off a tight win over the Cardinals in their last one, winning 31-27 at home against a backup QB, and they already have a loss in this building this season, their only loss coming in this building when they lost to the Rams a few weeks ago. The Chargers bounced back in their last one and got their run game going once again which is going to be big for that offense in this game. The Colts have also been beating up on a lot of bad teams this year, now they have to play one of the best teams in the AFC. The best way to place a bet here is on the Chargers to cover the spread in this game.
Colts Chargers Prediction: Our NFL Pick for Sunday, October 19, 2025 (4:05 pm ET start time) is Chargers 27 Colts 23.
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NFL Betting Trends
Indianapolis Colts: 14-7 ATS in games where the line is +3 to -3. 19-9 ATS against conference opponents. 15-7 ATS in the first half of the season. 4-1 UNDER versus good offensive teams - averaging 5.65 yards/play or more.
Los Angeles Chargers: 3-8 ATS in a home game where the total is greater than or equal to 45.5. 3-9 ATS versus good offensive teams - averaging 5.65 yards/play or more. 2-6 ATS versus good rushing teams - averaging 130 rushing yards/game or more. 14-7 UNDER in all games where the total is between 42.5 and 49 points.
Key Injuries
Indianapolis Colts: G. Stewart (DL) Injured - Rest. J. Downs (WR) Injured - Concussion. A. Dulin (WR) Injured - Chest. T. Goodson (RB) Injured - Groin. K. Moore II (CB) Injured - Achilles. A. Pierce (WR) Injured - Ankle. B. Smith (OT) Injured - Rest. C. Ward (CB) Injured - Concussion.
Los Angeles Chargers: B. Bozeman (C) Injured - Illness. H. Haskins (RB) Injured - Chest. K. Allen (WR) Injured - NIR-Rest. K. Mack (LB) Injured - Elbow. D. Perryman (LB) Injured - Ankle. D. James Jr. (S) Injured - Rest. T. Dye (LB) Injured - Thumb. E. Molden (CB) Injured - Thumb. D. Henley (LB) Injured - Groin. S. Matlock (DL) Injured - Ankle. J. Salyer (OG) Injured - Knee. D. Davis (WR) Injured - Knee. T. Pipkins III (OG) Injured - Knee. Q. Johnston (WR) Injured - Hamstring. J. Alt (OT) Injured - Ankle. K. Kennard (LB) Injured - Knee.
Notable Quotes
“We knew it was going to be a back-and-forth game. And it was great to see the offense there at the end, go down and get that touchdown to go up 31-27." - Shane Steichen after his team’s win against the Cardinals in their last game.
“He’s able to just mighty-man it and shake it off and hit Ladd McConkey. I’m going to remember that play until they throw dirt over top of me. That’s how great I feel about that.” - Jim Harbaugh after his team’s win against the Dolphins in their last game.
Starting Lineups
Indianapolis Colts
WR Pittman Jr., Michael
WR Pierce, Alec
WR Gould, Anthony
TE Warren, Tyler
QB Jones, Daniel
RB Taylor, Jonathan
Los Angeles Chargers
WR Harris, Tre'
WR Allen, Keenan
WR McConkey, Ladd
TE Gadsden, Oronde
QB Herbert, Justin
RB Vidal, Kimani
FB Matlock, Scott
Statistical Leaders
Indianapolis Colts
Passing: Daniel Jones (1,502)
Rushing: Jonathan Taylor (603)
Receiving: Tyler Warren (370)
Touchdowns: Jonathan Taylor (8)
Los Angeles Chargers
Passing: Justin Herbert (1,493)
Rushing: Omarion Hampton (314)
Receiving: Quentin Johnston (377)
Touchdowns: Quentin Johnston (4)
Coaches:
Indianapolis Colts: Shane Steichen (3rd season)
Los Angeles Chargers: Jim Harbaugh (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
