Indianapolis Colts vs Kansas City Chiefs Prediction, Preview and Odds - 09/20/2026

Game Time: 8:20 pm ET, Sunday, September 20, 2026

Venue:  Arrowhead Stadium, Kansas City, MO

Where to Watch:  NBC

DraftKings:  Point Spread:  Colts +6.5, Chiefs -6.5; Over/Under:  46.5 points

Bet365:  Point Spread:  Colts +6.5, Chiefs -6.5; Over/Under:  46.5 points

BetMGM:  Point Spread:  Colts +6.5, Chiefs -6.5; Over/Under:  46.5 points

Indianapolis Colts:  0-1 (2nd place, AFC South)

Kansas City Chiefs:  1-0 (1st place, AFC West)

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Indianapolis Colts:  lost their last game at home against the Baltimore Ravens 41-23.

Kansas City Chiefs:  won their last game at home against the Denver Broncos 31-10.

The Colts are entering this game with a 0-1 record overall and they have a 0-0 record in their divisional games too. They are 0-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Baltimore Ravens 41-23. Daniel Jones was the starting QB and he completed 19/31 passes for 166 passing yards, 1 touchdown, and 1 interception. Jonathan Taylor led the team in rushing yards with 98 and 2 TDs. Alec Pierce led the receivers with 61 receiving yards on 4 receptions. Akeem Davis-Gaither led the defense in that game with 8 solo tackles while Laiatu Latu, Arden Key, DeForest Buckner, and Grover Stewart each led the defense in sacks with 0.5. No one on the defense came away with an interception for them in that one.

 

 

 

The Chiefs are entering this game with a 1-0 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Denver Broncos 31-10. Patrick Mahomes was the starting QB and he completed 15/27 passes for 184 passing yards, 2 touchdowns, and 1 interception. Kenneth Walker III led the team in rushing yards with 173 and 1 TD. Travis Kelce led the receivers with 71 receiving yards on 3 receptions. L'Jarius Sneed led the defense in that game with 8 solo tackles while Nohl Williams, R Mason Thomas, and Felix Anudike-Uzomah each led the defense in sacks with 1. Mansoor Delane came away with the only interception for them in that one.

The current betting odds have the Chiefs listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Chiefs have looked great in their games this season with their 1-0 record overall and their 1-0 record in the division. They have looked good on their home field too with their 1-0 home record so far. Meanwhile, the Colts have looked terrible in their games this season with their 0-1 record overall so far. They haven't played any road games yet and will be playing their 1st road game of the year here. The Colts are coming off a 41-23 loss to the Ravens at home and they looked terrible in that game. The offense didn't look that bad, but they were chasing the whole game and Taylor was also the saving grace for them with Daniel Jones not looking great. The defense also looked terrible and the Ravens could have put up a lot more points in that game. The Chiefs are coming off a 31-10 win over the Broncos in week 1 and they look like they are back as one of the best teams in the NFL. They had a down year last season going 6-11, but they came out with an edge in week 1 and put the screws to one of the best defenses in the NFL. Kenneth Walker has unlocked a new kind of offense for them and they are going to destroy that Colts defense the same way that the Ravens did through their rushing attack. The Chiefs always bring their best effort for prime time games too and they are playing this season with a chip on their shoulder after that disaster season last year. The Colts were a disaster themselves going back to the back half of last season and nothing has changed for them to start this new year. The best way to place a bet here is on the Chiefs to cover the spread in this game. 

Colts Chiefs Prediction:  Our NFL Pick for Sunday, September 20, 2026 (8:20 pm ET start time) is Chiefs 35 Colts 17.

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Indianapolis Colts: 4-1 ATS against AFC West division opponents. 8-3 ATS as a road underdog. 16-9 ATS against conference opponents. 6-3 UNDER on the road in the first half of the regular season.

Kansas City Chiefs: 1-5 ATS against AFC South division opponents. 3-13 ATS as a favorite of 3.5 to 9.5 points. 3-8 ATS after playing a division game. 12-5 UNDER as a favorite of 3.5 to 9.5 points.

Indianapolis Colts:  D. Giddens (RB) Injured - Knee. G. Stewart (DL) Injured - Personal. A. Richardson Sr. (QB) Injured - Groin. A. Ajiake (LB) Injured - Hamstring. K. Allen (WR) Injured - Rest. D. Buckner (DL) Injured - Ankle. A. Davis-Gaither (LB) Injured - Knee. A. Dulin (WR) Injured - Ankle. A. Pierce (WR) Injured - Heel.

Kansas City Chiefs:  C. Jones (DL) Injured - Calf. R. Rice (WR) Injured - Knee. L. Sneed (CB) Injured - Knee. R. Thomas (DL) Injured - Hamstring. P. Mahomes (QB) Injured - Knee. C. Conner (CB) Injured - Knee. J. Simmons (OT) Injured - Back. M. Delane (CB) Injured - Shoulder. A. Gillotte (DL) Injured - Foot.

“Obviously, we've got to be better. We've got to coach better. We've got to play better. They had a ton of yards. We've got to be better there, but it's not just about one group. We weren't good enough.” - Shane Steichen after his team’s loss against the Ravens in their last game. 

“He did a really nice job and you never know going in how many times you're going to give him the ball. That's not a calculated thing. You have to be making yards. For him to play the way he did I thought was spectacular.” - Andy Reid after his team’s win against the Broncos in their last game. 

WR Pierce, Alec

WR Allen, Keenan

WR Downs, Josh

TE Warren, Tyler

QB Jones, Daniel

RB Taylor, Jonathan

WR Thornton, Tyquan

WR Worthy, Xavier

WR Rice, Rashee

TE Kelce, Travis

QB Mahomes, Patrick

RB Walker, Kenneth

FB VanSumeren, Ben

Passing: Daniel Jones (166)

Rushing: Jonathan Taylor (98)

Receiving: Alec Pierce (61)

Touchdowns: Jonathan Taylor (2)

Passing: Patrick Mahomes (184)

Rushing: Kenneth Walker III (173)

Receiving: Travis Kelce (71)

Touchdowns: Kenneth Walker III (2)

Coaches:

Indianapolis Colts: Shane Steichen (4th season)

Kansas City Chiefs: Andy Reid (14th season)