Indiana Hoosiers vs Oregon Ducks Prediction, Picks and Game Preview - 10/11/2025

Game Time: 3:30 pm ET, Saturday, October 11, 2025

Venue:  Autzen Stadium, Eugene, OR

Where to Watch:  CBS

DraftKings:  Point Spread:  Indiana +7.5, Oregon -7.5; Over/Under:  54.5 points

Bet365:  Point Spread:  Indiana +7.5, Oregon -7.5; Over/Under:  54.5 points

BetMGM:  Point Spread:  Indiana +8.5, Oregon -8.5; Over/Under:  55.5 points

Indiana Hoosiers:  5-0 (2-0) (1st place, Big Ten)

Oregon Ducks:  5-0 (2-0) (2nd place, Big Ten)

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Indiana Hoosiers:  won their last game on the road against the Iowa Hawkeyes 20-15.

Oregon Ducks:  won their last game on the road against the Penn State Nittany Lions 30-24 in overtime. 

Indiana is entering this game with a 5-0 record overall and they have a 2-0 record in their conference games too. They are 4-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Iowa 20-15. Fernando Mendoza was the starting QB and he completed 13/23 passes for 233 passing yards, 2 touchdowns, and 1 interception. Roman Hemby led the team in rushing yards with 86. Elijah Sarratt led the receivers with 132 receiving yards on 6 receptions and 1 TD. Aiden Fisher led the defense in that game with 5 solo tackles and 2 assisted tackles while Isiah Jones and Kellan Wyatt each led the defense in sacks with 0.5. Amare Ferrell came away with the only interception for them in that one.

 

 

 

Oregon is entering this game with a 5-0 record overall and they have a 2-0 record in their conference games too. They are 3-0 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Penn State 30-24 in OT. Dante Moore was the starting QB and he completed 29/39 passes for 248 passing yards, 3 touchdowns, and 0 interceptions. Dierre Hill Jr. led the team in rushing yards with 82. Dakorien Moore led the receivers with 89 receiving yards on 7 receptions. Teitum Tuioti led the defense in that game with 4 solo tackles and 1 assisted tackle while Teitum Tuioti and Matayo Uiagalelei each led the defense in sacks with 1. Dillon Thieneman came away with the only interception for them in that one.

The current betting odds have Oregon listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. Oregon has looked great in their games this season with their 5-0 record overall and their 2-0 conference record which has them right near the top of the Big Ten. They are off a big road win over Penn State in their last one which is going to give them some momentum going forward, beating a top 5 team at the time, and now they are coming out of their bye week so they have had some extra time to prepare for this game. Oregon has looked great all season as they once again have been rolling over every opponent they play, and they once again look like one of the best teams in the nation. A lot of that is due to the standard that Dan Lanning has kept over the last few years and they are going to bring their best effort for another ranked opponent in the conference. Meanwhile, Indiana has looked great in their games this season with their 5-0 record overall and their 2-0 conference record which has them right near the top of the Big Ten. They are also coming out of their bye week and they have some good wins under their belt this year, beating Illinois 63-10 and coming off a tough 20-15 road win over Iowa, but this isn't going to be an easy trip for them to make. Last season, Indiana made it to the playoffs because of a weaker schedule where Ohio State was the only true contender they faced, but this game is going to be a real test for them. They did not handle these kinds of opponents well last season and as good as they have looked this year, they still don't have the talent that this Oregon team has brought in. Indiana has a chance to make a big statement here, but so does Oregon and they have the more talented team on both sides of the ball. The best way to place a bet here is on Oregon to cover the spread in this game. 

Indiana Oregon Prediction:  Our NCAAF Pick for Saturday, October 11, 2025 (3:30 pm ET start time) is Oregon 34 Indiana 17.

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Indiana Hoosiers: 20-30 ATS in a road game where the total is between 49.5 and 56. 12-24 ATS after a bye week. 32-46 ATS versus good rushing teams - averaging 200  rushing yards/game or more. 20-10 OVER in all lined games. 9-2 OVER in road lined games. 8-2 OVER vs. good teams - outscoring opponents by 10+ PPG on the season.

Oregon Ducks: 21-11 ATS in all lined games. 19-10 ATS as a favorite. 12-6 ATS off a win against a conference rival. 7-2 ATS when playing against a top-level team (Win Pct. > 75%). 7-4 OVER when the total is between 49.5 and 56. 4-0 OVER vs. good passing defenses - allowing 5.75 or less passing yards/att.

Indiana Hoosiers:  B. Baldwin Jr. (CB) Questionable - Undisclosed. B. Bonds (CB) Out - Undisclosed. D. Ponds (CB) Questionable - Undisclosed. L. Beebe Jr. (RB) Out - Leg. T. Morris (WR) Out - Knee.

Oregon Ducks:  M. Hughes (RB) Out - Redshirt. K. Sadiq (TE) Questionable - Undisclosed. J. Ressler (WR) Questionable - Undisclosed. D. Gresham (WR) Questionable - Undisclosed. D. Brew (CB) Questionable - Undisclosed. B. Platt (LB) Questionable - Undisclosed. B. Boulton (OG) Out - Undisclosed. E. Stewart (WR) Out - Knee. T. McNutt (CB) Out - Leg.

“It was the good, the bad, and the ugly, and there was a lot of the bad and the ugly.” - Curt Cignetti after his team’s win against Iowa in their last game. 

“We just talked all week about it’s about getting a cut. It’s death by 1,000 cuts. Eventually that cut was going to be a jugular and that last interception was a jugular.” - Dan Lanning after his team’s win against PSU in their last game. 

WR Sarratt, Elijah

WR Williams Jr., E.J.

WR Cooper Jr., Omar

TE Nowakowski, Riley

QB Mendoza, Fernando

RB Hemby, Roman

WR Benson, Malik

WR Moore, Dakorien

WR Bryant Jr., Gary

TE Sadiq, Kenyon

QB Moore, Dante

RB Whittington, Noah

Passing: Fernando Mendoza (1,208)

Rushing: Roman Hemby (351)

Receiving: Omar Cooper Jr. (432)

Touchdowns: Omar Cooper Jr. (7)

Passing: Dante Moore (1,210)

Rushing: Dierre Hill Jr. (270)

Receiving: Dakorien Moore (296)

Touchdowns: Jordon Davison (7)

Coaches:

Indiana Hoosiers: Curt Cignetti (2nd season)

Oregon Ducks: Dan Lanning (4th season)