Indiana Hoosiers vs Nebraska Cornhuskers Prediction, Picks and Game Preview - 10/10/2026

Game Time: 12:00 pm ET, Saturday, October 10, 2026

Venue:  Memorial Stadium, Lincoln, NE

Where to Watch:  FOX

DraftKings:  Point Spread:  Indiana -7.5, Nebraska +7.5; Over/Under:  51.5 points

Bet365:  Point Spread:  Indiana -7.5, Nebraska +7.5; Over/Under:  51.5 points

BetMGM:  Point Spread:  Indiana -7.5, Nebraska +7.5; Over/Under:  52.5 points

Indiana Hoosiers:  5-0 (2-0) (1st place, Big Ten)

Nebraska Cornhuskers:  5-0 (2-0) (1st place, Big Ten)

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Indiana Hoosiers:  won their last game on the road against the Rutgers Scarlet Knights 47-15.

Nebraska Cornhuskers:  won their last game at home against the Maryland Terrapins 48-23.

Indiana is entering this game with a 5-0 record overall and they have a 2-0 record in their conference games too. They are 4-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Rutgers 47-15. Josh Hoover was the starting QB and he completed 20/27 passes for 251 passing yards, 4 touchdowns, and 0 interceptions. Turbo Richard led the team in rushing yards with 204 and 1 TD. Nick Marsh led the receivers with 120 receiving yards on 7 receptions and 1 TD. Byron Baldwin Jr., Isaiah Jones, and Tobi Osunsanmi each led the defense in that game with 7 tackles while Stephen Daley led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

 

 

 

Nebraska is entering this game with a 5-0 record overall and they have a 2-0 record in their conference games too. They are 4-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Maryland 48-23. Anthony Colandrea was the starting QB and he completed 26/39 passes for 238 passing yards, 3 touchdowns, and 1 interception. Anthony Colandrea led the team in rushing yards with 108. Kwazi Gilmer led the receivers with 147 receiving yards on 11 receptions and 2 TDs. Owen Chambliss and Donovan Jones each led the defense in that game with 8 tackles while Vincent Shavers Jr. led the defense in sacks with 1. Dwayne McDougle and Kade Pietrzak each came away with 1 interception for them in that one.

The current betting odds have Indiana listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. Indiana has looked great in their games this season with their 5-0 record overall and their 2-0 conference record which has them right near the top of the Big Ten. They have been a good road team too with their 1-0 road record this year. Meanwhile, Nebraska has looked good in their games this season with their 5-0 record overall and their 2-0 conference record which has them right near the top of the Big Ten. They have looked great on their home field too with their 4-0 home record this season. Nebraska is coming off a 48-23 win over Maryland in their last one, but they really beat up on a team that was already down. Their only road game this year was a win over Michigan State, but Michigan State is still trying to rebuild their program. Nebraska has had a great start to the year, but they haven't really played any tough opponents and even their non-conference schedule wasn't that strong. This is going to be their first real challenge of the season and this is something that has been common with them in recent years, starting the season undefeated and then losing once they face their first real challenge. Indiana is in a similar boat since they haven't had a strong scedule to start the season and haven't looked great against some lesser opponents. They are also the defending National Champions though and haven't lost a game in well over a year, so they don't really need to prove themselves early on. They are coming off their first road game of the season too and they finally looked like the soul crushing team that they were last year, beating Rutgers 47-15 with their defense not giving much up. Indiana is going to start rolling now that they have an opportunity to take down an undefeated team in the conference and that defense has looked like one of the best defenses in the nation, just like last season. The best way to place a bet here is on Indiana to cover the spread in this game. 

Indiana Nebraska Prediction:  Our NCAAF Pick for Saturday, October 10, 2026 (12:00 pm ET start time) is Indiana 38 Nebraska 17.

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Indiana Hoosiers: 7-2 ATS as a favorite of 3.5 to 10 points. 8-4 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 8-4 ATS vs. good defensive teams who give up 17 or less points/game. 14-6 OVER when the total is between 49.5 and 56. 15-7 OVER against conference opponents.

Nebraska Cornhuskers: 1-4 ATS as an underdog of 3.5 to 10 points. 4-9 ATS when playing against a team with a winning record. 2-7 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 12-6 OVER in home lined games. 6-2 OVER vs. good defensive teams who give up 17 or less points/game.

Indiana Hoosiers:  L. Beebe Jr. (RB) Questionable - Undisclosed. T. Richard (RB) Probable - Ankle. L. Bond (WR) Out - Undisclosed.

Nebraska Cornhuskers:  C. Nelson (TE) Questionable - Leg. J. Rule (RB) Questionable - Undisclosed. L. Miles (WR) Out - Undisclosed.

“We had good news on Turbo early in the week. We felt confident about him. Beebe, kind of came up with something early in the week and there was some concern but after about 24 hours we felt pretty good about it.” - Curt Cignetti after his team’s win against Rutgers in their last game. 

“The way we play, it’s maybe not all the time the coolest thing, the visual, but we’re going to try to be physical. Sometimes we might go three and out, but if we continue to be physical, we give ourselves a chance in the fourth quarter.” - Matt Rhule after his team’s win against Maryland in their last game. 

WR Marsh, Nick

WR Becker, Charlie

WR Morris, Tyler

TE Barker, Andrew

QB Hoover, Josh

RB Richard, Turbo

WR Hunter, Nyziah

WR Gilmer, Kwazi

WR Barney Jr., Jacory

TE Lindenmeyer, Luke

QB Colandrea, Anthony

RB Mozee, Isaiah

Passing: Josh Hoover (1,101)

Rushing: Turbo Richard (587)

Receiving: Charlie Becker (477)

Touchdowns: Charlie Becker (8)

Passing: Anthony Colandrea (1,142)

Rushing: Jamal Rule (333)

Receiving: Kwazi Gilmer (387)

Touchdowns: Kwazi Gilmer (6)

Coaches:

Indiana Hoosiers: Curt Cignetti (3rd season)

Nebraska Cornhuskers: Matt Rhule (4th season)