Indiana Hoosiers vs Iowa Hawkeyes Prediction, Picks and Game Preview - 09/27/2025

Game Time: 3:30 pm ET, Saturday, September 27, 2025

Venue:  Kinnick Stadium, Iowa City, IA

Where to Watch:  Peacock

DraftKings:  Point Spread:  Indiana -7.5, Iowa +7.5; Over/Under:  48.5 points

Bet365:  Point Spread:  Indiana -7.5, Iowa +7.5; Over/Under:  48.5 points

BetMGM:  Point Spread:  Indiana -7.5, Iowa +7.5; Over/Under:  48.5 points

Indiana Hoosiers:  4-0 (1-0) (1st place, Big Ten)

Iowa Hawkeyes:  3-1 (1-0) (6th place, Big Ten)

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Indiana Hoosiers:  won their last game at home against the Illinois Fighting Illini 63-10.

Iowa Hawkeyes:  won their last game on the road against the Rutgers Scarlet Knights 38-28.

Indiana is entering this game with a 4-0 record overall and they have a 1-0 record in their conference games too. They are 4-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Illinois 63-10. Fernando Mendoza was the starting QB and he completed 21/23 passes for 267 passing yards, 5 touchdowns, and 0 interceptions. Khobie Martin led the team in rushing yards with 107 and 2 TDs. Elijah Sarratt led the receivers with 92 receiving yards on 9 receptions and 2 TDs. Louis Moore led the defense in that game with 5 solo tackles and 1 assisted tackle while Tyrique Tucker and Mario Landino each led the defense in sacks with 2. Amare Ferrell came away with the only interception for them in that one.

 

 

 

Iowa is entering this game with a 3-1 record overall and they have a 1-0 record in their conference games too. They are 2-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Rutgers 38-28. Mark Gronowski was the starting QB and he completed 12/18 passes for 186 passing yards, 0 touchdowns, and 0 interceptions. Kamari Moulton led the team in rushing yards with 68 and 1 TD. Dayton Howard led the receivers with 42 receiving yards on 1 reception. TJ Hall led the defense in that game with 4 solo tackles and 3 assisted tackles while Karson Sharar, Ethan Hurkett, and Max Llewellyn each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Indiana listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. Indiana has looked great in their games this season with their 4-0 record overall. They are coming off a big statement win against Illinois in their last one and not only did they win that game against another ranked opponent, they embarrassed Illinois with a 63-10 win. Indiana is looking to follow up a great season which they went to the CFP with another great season and they are showing why they could be even better this year. Meanwhile, Iowa has looked good in their games this season with their 3-1 record overall. They are off a 38-28 road win over Rutgers in their last one and they finally found their offense in that game, but their defense wasn't great. Iowa always has a great defense every year, but that defense is about to get tested in this one and Indiana has a lot more talent than some of the teams that Iowa has seen already. They also put up 38 points in that one, but that won't be easy for them to repeat against this better Indiana defense, and even though they put up 38 points, the offense still wasn't great statistically. Indiana has a really good defense that is going to cause issues for this Iowa offense, and Indiana has the offensive power to run away with this game. The best way to place a bet here is on Indiana to cover the spread in this game. 

Indiana Iowa Prediction:  Our NCAAF Pick for Saturday, September 27, 2025 (3:30 pm ET start time) is Indiana 45 Iowa 10.

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Indiana Hoosiers: 19-10 ATS in all lined games. 6-1 ATS as a favorite of 3.5 to 10 points. 13-6 ATS against conference opponents. 10-2 ATS after allowing 14 points or less last game. 20-9 OVER in all lined games. 9-1 OVER in road lined games.

Iowa Hawkeyes: 2-5 ATS as an underdog. 27-39 ATS in a home game where the total is between 42.5 and 49. 0-3 ATS off a road win against a conference rival. 5-2 OVER after scoring 37 points or more last game. 15-7 OVER vs. good passing defenses - allowing 150 or less passing yards/game.

Indiana Hoosiers:  L. Beebe Jr. (RB) Out - Leg. B. Bonds (CB) Questionable - Undisclosed. B. Baldwin Jr. (CB) Questionable - Undisclosed. T. Morris (WR) Out - Knee.

Iowa Hawkeyes:  J. Patterson (RB) Out - Undisclosed. R. Vander Zee (WR) Questionable - Foot. X. Williams (RB) Questionable - Arm. B. Doll (RB) Questionable - Undisclosed. S. Barros (CB) Questionable - Undisclosed. J. Buie (WR) Questionable - Undisclosed. A. Ostrenga (TE) Out - Undisclosed.

“We’ll get people's attention with this one. The team really laid it on the line tonight. There’s nothing better than being the Grinch in the second half with a big lead. I love that feeling.” - Curt Cignetti after his team’s win against Illinois in their last game. 

"Coach Cignetti has come in and done a great job. Really upgraded their personnel last year, and beyond that, they're really well-coached. You didn't see a game where they didn't play hard and look like a really good football team.” - Kirk Ferentz on his team’s upcoming game against Indiana this week.

WR Sarratt, Elijah

WR Williams Jr., E.J.

WR Cooper Jr., Omar

TE Nowakowski, Riley

QB Mendoza, Fernando

RB Hemby, Roman

WR Phillips, Sam

WR Gill, Jacob

WR Anderson, Seth 

TE Ortwerth, Zach

QB Gronowski, Mark

RB Washington Jr., Terrell

Passing: Fernando Mendoza (975)

Rushing: Kaelon Black (306)

Receiving: Omar Cooper Jr. (377)

Touchdowns: Omar Cooper Jr. (6)

Passing: Mark Gronowski (492)

Rushing: Jaziun Patterson (198)

Receiving: Sam Phillips (115)

Touchdowns: Mark Gronowski (6)

Coaches:

Indiana Hoosiers: Curt Cignetti (2nd season)

Iowa Hawkeyes: Kirk Ferentz (27th season)