Houston Texans vs Jacksonville Jaguars Prediction, Preview and Odds - 09/21/2025

Game Time: 1:00 pm ET, Sunday, September 21, 2025

Venue:  EverBank Stadium, Jacksonville, FL

Where to Watch:  CBS

DraftKings:  Point Spread:  Texans +2.5, Jaguars -2.5; Over/Under:  44.5 points

Bet365:  Point Spread:  Texans +2, Jaguars -2; Over/Under:  44 points

BetMGM:  Point Spread:  Texans +2, Jaguars -2; Over/Under:  44 points

Houston Texans:  0-2 (3rd place, AFC South)

Jacksonville Jaguars:  1-1 (2nd place, AFC South)

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Houston Texans:  lost their last game at home against the Tampa Bay Buccaneers 20-19.

Jacksonville Jaguars:  lost their last game on the road against the Cincinnati Bengals 31-27.

The Texans are entering this game with a 0-2 record overall and they have a 0-0 record in their divisional games too. They are 0-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Tampa Bay Buccaneers 20-19. C. J. Stroud was the starting QB and he completed 13/24 passes for 207 passing yards, 1 touchdown, and 0 interceptions. Nick Chubb led the team in rushing yards with 43 and 1 TD. Nico Collins led the receivers with 52 receiving yards on 3 receptions and 1 TD. Azeez Al-Shaair led the defense in that game with 8 solo tackles and 2 assisted tackles while Danielle Hunter led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

 

 

 

The Jaguars are entering this game with a 1-1 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Cincinnati Bengals 31-27. Trevor Lawrence was the starting QB and he completed 24/42 passes for 271 passing yards, 3 touchdowns, and 2 interceptions. Travis Etienne Jr. led the team in rushing yards with 71. Parker Washington led the receivers with 76 receiving yards on 5 receptions. Jourdan Lewis led the defense in that game with 5 solo tackles and 3 assisted tackles while Foyesade Oluokun, Travon Walker, and Arik Armstead each led the defense in sacks with 1. Eric Murray, Andrew Wingard, and Devin Lloyd each came away with 1 interception for them in that one.

The current betting odds have the Jaguars listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. The Jaguars have a 1-1 record overall and they are off their first loss of the season. They lost on the road to the Bengals 31-27, but they were leading for most of that game. They had that victory snatched away from them late so they are going to be motivated to bring their best effort here with the division up for grabs this year. Meanwhile, the Texans have looked terrible in their games this season with their 0-2 record overall. Their defense has looked good and has been keeping them in a lot of games, but their offense has looked terrible. They don't really have a solid run game with Nick Chubb and Stroud hasn't been at his best either. They are also at a disadvantage here since they played on Monday night and won't have as much time to prepare for this game as the Jags. The Jags may have lost their last game, but they looked great for most of that game as Liam Coen has them heading in the right direction in his 1st season coaching. This is a big game for the Jags at home to make a statement in the AFC South and announce themselves as a threat in a wide open division. The best way to place a bet here is on the Jaguars to cover the spread in this game. 

Texans Jaguars Prediction:  Our NFL Pick for Sunday, September 21, 2025 (1:00 pm ET start time) is Jaguars 23 Texans 20.

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Houston Texans: 4-8 ATS in a road game where the total is between 42.5 and 49 points. 6-10 ATS after playing on Monday night football. 1-7 ATS in September games. 24-14 UNDER in all games. 20-5 UNDER in all games where the total is between 42.5 and 49 points. 

Jacksonville Jaguars: 8-3 ATS versus division opponents. 5-1 1H ATS as a home favorite of 7 points or less. 11-3 UNDER in games where the line is +3 to -3. 7-1 UNDER off a road loss. 10-3 UNDER after playing their last game on the road.

Houston Texans:  C. Kirk (WR) Injured - Hamstring. B. Berrios (WR) Injured - Hamstring. J. Smith (CB) Injured - Hamstring. D. Taylor (DL) Injured - Hip. J. Andrews (C) Injured - Ankle. K. Lassiter (CB) Injured - Knee. J. Pitre (S) Injured - Ribs.

Jacksonville Jaguars:  E. Cleveland (OG) Injured - Ankle. H. Long (TE) Injured - Ankle. J. Jones (CB) Injured - Back. W. Milum (OG) Injured - Knee. B. Tuten (RB) Injured - Shoulder. M. Brown (CB) Injured - Ankle. B. Thomas Jr. (WR) Injured - Wrist.

“We had multiple opportunities to win that game and we didn’t make the plays we needed to make.” - DeMeco Ryans after his team’s loss against the Buccaneers in their last game. 

“I thought he was getting us in and out of the right things and made a lot of good throws. We can win with him playing like that and limiting the turnovers.” - Liam Coen on Trevor Lawrence after his team’s loss against the Bengals in their last game. 

WR Collins, Nico

WR Higgins, Jayden

WR Kirk, Christian

TE Schultz, Dalton

QB Stroud, C.J.

RB Chubb, Nick

FB Brooks, British

WR Thomas Jr., Brian

WR Brown, Dyami

WR Hunter, Travis

TE Strange, Brenton

QB Lawrence, Trevor 

RB Etienne Jr., Travis

Passing: C. Stroud (395)

Rushing: N. Chubb (103)

Receiving: N. Collins (77)

Touchdowns: N. Collins (1)

Passing: T. Lawrence (449)

Rushing: T. Etienne Jr. (214)

Receiving: D. Brown (109)

Touchdowns: B. Thomas Jr. (1)

Coaches:

Houston Texans: DeMeco Ryans (3rd season)

Jacksonville Jaguars: Liam Coen (1st season)