Houston Texans vs Indianapolis Colts Prediction, Preview and Odds - 09/27/2026

Game Time: 1:00 pm ET, Sunday, September 27, 2026

Venue:  Lucas Oil Stadium, Indianapolis, IN

Where to Watch:  CBS

DraftKings:  Point Spread:  Texans -1.5, Colts +1.5; Over/Under:  42.5 points

Bet365:  Point Spread:  Texans -1.5, Colts +1.5; Over/Under:  42.5 points

BetMGM:  Point Spread:  Texans -1.5, Colts +1.5; Over/Under:  42.5 points

Houston Texans:  0-2 (2nd place, AFC South)

Indianapolis Colts:  0-2 (2nd place, AFC South)

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Houston Texans:  lost their last game at home against the Cincinnati Bengals 20-6.

Indianapolis Colts:  lost their last game on the road against the Kansas City Chiefs 33-30 in overtime. 

The Texans are entering this game with a 0-2 record overall and they have a 0-0 record in their divisional games too. They are 0-2 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Cincinnati Bengals 20-6. C. J. Stroud was the starting QB and he completed 30/55 passes for 353 passing yards, 0 touchdowns, and 0 interceptions. C. J. Stroud led the team in rushing yards with 29. Dalton Schultz led the receivers with 140 receiving yards on 12 receptions. Azeez Al-Shaair led the defense in that game with 12 solo tackles while Will Anderson Jr., Logan Hall, Sheldon Rankins, and Danielle Hunter each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Colts are entering this game with a 0-2 record overall and they have a 0-1 record in their divisional games too. They are 0-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Kansas City Chiefs 33-30 in OT. Daniel Jones was the starting QB and he completed 22/31 passes for 210 passing yards, 1 touchdown, and 1 interception. Jonathan Taylor led the team in rushing yards with 92 and 2 TDs. Josh Downs led the receivers with 72 receiving yards on 7 receptions. Akeem Davis-Gaither led the defense in that game with 14 solo tackles while DeForest Buckner and Jerry Tillery each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the Texans listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Texans have looked terrible in their games this season with their 0-2 record overall so far. They haven't played any road games yet and will be playing their 1st road game of the season here. Meanwhile, the Colts have looked terrible in their games this season with their 0-2 record overall so far. They haven't looked great on their home field either with their 0-1 home record this season. The Colts are coming off a 33-30 loss to the Chiefs in their last one and they looked a lot better in that game. They got crushed at home by the Ravens in week 1 and looked a lot better against the Chiefs, taking them to OT. The offense looked a lot better in that game too, but the defense didn't and that has been a big issue for them in their 2 games, giving up a ton of yards and points. The Texans haven't looked good this season either. They opened the season with a 36-31 loss to the Bills and now they are coming off a 20-6 loss to the Bengals in their last one. Their offense looked terrible against the Bengals in that one, but they did have a great week 1 against the Bills and have started the season against 2 really good teams. They had one of the best defenses in the NFL last season and they looked terrible against the Bills in week 1, but they looked a lot better last week, the offense couldn't help them out though. The Texans have been getting better on defense in each game though and that defense will be the key factor in this game as the Texans are the better team and will bounce back against this Colts defense that might be one of the worst in the NFL. The best way to place a bet here is on the Texans to cover the spread in this game. 

Texans Colts Prediction:  Our NFL Pick for Sunday, September 27, 2026 (1:00 pm ET start time) is Texans 21 Colts 17.

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Houston Texans: 6-12 ATS in all games where the total is between 42.5 and 49 points. 4-7 ATS versus division opponents. 13-25 ATS in dome games. 16-3 UNDER in all games where the total is between 42.5 and 49 points.

Indianapolis Colts: 17-9 ATS against conference opponents. 8-4 ATS versus division opponents. 7-3 ATS in the first month of the regular season. 66-44 UNDER at home versus division opponents.

Houston Texans:  J. Clowney (DL) Injured - Knee. T. Brown (OT) Injured - Knee. D. Schultz (TE) Injured - Rest. M. Stewart (S) Injured - Knee. J. Hummel (LB) Injured - Groin. E. Ingram (OG) Injured - Groin. N. Collins (WR) Injured - Hamstring. R. Blankenship (S) Injured - Thumb. L. Hall (DL) Injured - Knee. W. Anderson Jr. (DL) Injured - Rest. W. Woodaz (LB) Injured - Thumb.

Indianapolis Colts:  K. Allen (WR) Injured - Rest. A. Dulin (WR) Injured - Ankle. S. Gardner (CB) Injured - Rib. M. Goncalves (OG) Injured - Foot. A. Pierce (WR) Injured - Heel. J. Taylor (RB) Injured - Rest. L. Treadwell (WR) Injured - Shoulder. C. Ward (CB) Injured - Groin.

“The one key to this victory was controlling the front and from an offensive perspective we did not control their front. We got outplayed up front. We couldn’t run the ball well and that forced us into a lot of passing situations.” - DeMeco Ryans after his team’s loss against the Bengals in their last game. 

“Had a play called. Had to love the look to run it there. We took the delay and kicked the field goal.” - Shane Steichen after his team’s loss against the Chiefs in their last game. 

WR Collins, Nico

WR Boutte, Kayshon

WR Hutchinson, Xavier

TE Schultz, Dalton

QB Stroud, C.J.

RB Montgomery, David

FB Brooks, British

WR Treadwell, Laquon

WR Allen, Keenan

WR Downs, Josh

TE Warren, Tyler

QB Jones, Daniel

RB Taylor, Jonathan

Passing: C.J. Stroud (627)

Rushing: David Montgomery (70)

Receiving: Dalton Schultz (175)

Touchdowns: David Montgomery (3)

Passing: Daniel Jones (376)

Rushing: Jonathan Taylor (190)

Receiving: Josh Downs (109)

Touchdowns: Jonathan Taylor (4)

Coaches:

Houston Texans: DeMeco Ryans (4th season)

Indianapolis Colts: Shane Steichen (4th season)