Houston Astros vs Detroit Tigers Prediction, Preview and Odds - 08/20/2025

Game Time: 1:10 pm ET, Wednesday, August 20, 2025

Venue:  Comerica Park, Detroit, MI

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Astros -132, Tigers +108; Over/Under:  8 runs

Bet365:  Moneyline odds:  Astros -130, Tigers +110; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Astros -130, Tigers +110; Over/Under:  8 runs

Houston Astros:  69-56 (1st place, AL West)

Detroit Tigers:  74-53 (1st place, AL Central)

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Houston Astros:  5-5 last 10

Detroit Tigers:  7-3 last 10

The Astros are entering this series off a loss and lost their 3-game series against the Baltimore Orioles 2-1 in their last series. They enter this game with a 69-56 record overall and have a road record of 31-29. This is the series finale of a 3-game series with the Tigers on Wednesday with the 2nd game still to be played on Tuesday. The Astros lost the series opener on Monday. Their offense ranks 13th in the MLB with a .720 OPS. Hunter Brown is their starting pitcher on Tuesday while Framber Valdez is making his start in this game on Wednesday. He is 11-6 with a 3.01 ERA this season. His team lost their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 1 HR, and 1 BB with 6 SO on 9 hits through 6.2 IP against the Baltimore Orioles.

The Tigers are entering this series off a loss and won their 4-game series against the Minnesota Twins 3-1 in their last series. They enter this game with a 74-53 record overall and have a home record of 40-24. This is the 3rd game of a 3-game series with the Astros on Wednesday with the 2nd game of this series still to be played on Tuesday. The Tigers won the 1st game of this series on Monday. Their offense ranks 9th in the MLB with a .741 OPS. Tarik Skubal is their starting pitcher on Tuesday while Charlie Morton is making his start in this game on Wednesday. He is 8-10 with a 5.20 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 3 walks with 5 strikeouts on 2 hits through 6 innings pitched against the Minnesota Twins.

The current betting odds have the Astros listed as a slight favorite in this game according to Draftkings Sportsbook. The Tigers have looked great in their games this season with their 74-53 record overall which has them right at the top of the AL Central. They have also looked great in their own ballpark this year with their 40-24 home record. Meanwhile, the Astros have looked great in their games this season with their 69-56 record overall which has them right at the top of the AL West. They have been a good road team too with their 31-29 road record this season. The Astros haven't been as hot as the Tigers lately since the Astros are only 5-5 in their last 10 games while the Tigers are 7-3, but the Astros do have the better pitching matchup in this one and they can take advantage of that. Valdez is on the mound for the Astros in this one and he has looked great this season. He is 11-6 with a 3.01 ERA and he has been one of their best starters all year. He has struggled more lately as he did give up 3 earned runs in his last start and the team has lost 4 games in a row now with him starting too, but he will be looking to bounce back with a better start here since that hasn't been a common theme for him all season. The Tigers aren't going to have a solid starter themselves as they are going with Morton in this one. He is 8-10 with a 5.20 ERA and he has been giving up a lot of runs all year. He is finally coming off his first good start for the Tigers as he gave up no runs, but that hasn't been a common theme for him and the team has still lost 2 of their last 3 games with him. He was terrible before he got traded to the Tigers too and the change of scenery hasn't done much for him yet. The Astros haven't been at their best lately, but they still have a great offense that can put up runs and they have a big edge with the pitching matchup in this one. The best way to place a bet here is on the Astros to win this game.  

Astros Tigers Prediction:  Our MLB Pick for Wednesday, August 20, 2025 (1:10 pm ET start time) is Astros 7 Tigers 3.

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Houston Astros: 50-44 (-13.9 units) on the moneyline against AL Central opponents. 254-206 (-9 units) on the moneyline in all games. 170-141 (-42.5 units) on the moneyline as a favorite of -110 or higher. 81-53 OVER vs. good power teams - averaging 1.25 or more HR's/game.

Detroit Tigers: 242-217 (+32.3 units) on the moneyline in all games. 108-139 (+9.5 units) on the moneyline as an underdog of +100 or higher. 59-49 (+12.6 units) on the moneyline against left-handed starters. 16-9 OVER against AL West opponents.

Houston Astros:  C. Javier (SP) Day To Day - Illness. J. Hader (RP) Fifteen Day IL - Shoulder. I. Paredes (3B) Sixty Day IL - Hamstring. B. Walter (RP) Fifteen Day IL - Elbow. L. McCullers Jr. (SP) Ten Day IL - Finger. B. Rodgers (2B) Sixty Day IL - Oblique. J. Meyers (CF) Ten Day IL - Calf. Z. Dezenzo (RF) Sixty Day IL - Hand. Y. Alvarez (LF) Sixty Day IL - Hand. P. Leon (RF) Sixty Day IL - Knee. R. Blanco (SP) Sixty Day IL - Elbow. H. Wesneski (RP) Sixty Day IL - Elbow. L. Garcia (SP) Sixty Day IL - Elbow. J. France (SP) Sixty Day IL - Shoulder.

Detroit Tigers:  M. Vierling (CF) Ten Day IL - Oblique. P. Sewald (RP) Sixty Day IL - Shoulder. R. Olson (SP) Sixty Day IL - Shoulder. P. Meadows (CF) Ten Day IL - Quad. S. Guenther (RP) Sixty Day IL - Hip. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. T. Madden (SP) Sixty Day IL - Shoulder. J. Urquidy (SP) Sixty Day IL - Elbow.

“Yordan will make us better, and having Hunter Brown tomorrow is something to be optimistic [about]. I look forward to it, but we have to be better at doing the small stuff. We are a better club than we have shown [in] the last couple of games.” - Joe Espada after his team’s loss against the Tigers in their game on Monday.

“Wenceel’s at-bat was incredible, just really, really in the at-bat. We preach it: When we control the strike zone, look how good the at-bats get.” - A.J. Hinch after his team’s win against the Astros in their game on Monday.

Jeremy Peña (R) SS

Carlos Correa (R) 3B

Jose Altuve (R) 2B

Jesús Sánchez (L) LF

Christian Walker (R) 1B

Victor Caratini (S) C

Yainer Diaz (R) DH

Cam Smith (R) RF

Jacob Melton (L) CF

Colt Keith (L) 3B

Gleyber Torres (R) 2B

Kerry Carpenter (L) LF

Riley Greene (L) DH

Spencer Torkelson (R) 1B

Wenceel Pérez (S) RF

Dillon Dingler (R) C

Trey Sweeney (L) SS

Javier Báez (R) CF

Batting Average:  Carlos Correa (.339)

Hits:  Jose Altuve (130)

Home Runs:  Jose Altuve (22)

RBI:  Christian Walker (65)

Stolen Bases:  Jeremy Peña (17)

Wins:  Framber Valdez (11)

Saves:  Josh Hader (28)

ERA:  Enyel De Los Santos (0.00)

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (126)

Home Runs:  Riley Greene (29)

RBI:  Riley Greene (92)

Stolen Bases:  Zach McKinstry (19)

Wins:  Casey Mize (12)

Saves:  Will Vest (18)

ERA:  Kyle Finnegan (0.00)

Managers:

Houston Astros: Joe Espada (2nd season)

Detroit Tigers: A.J. Hinch (5th season)