by Rod Pearson
Tuesday, Sep 16, 2025
Game Time: 1:00 pm ET, Sunday, September 21, 2025
Venue: Huntington Bank Field, Cleveland, OH
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Packers -8.5, Browns +8.5; Over/Under: 42.5 points
Bet365: Point Spread: Packers -7.5, Browns +7.5; Over/Under: 42.5 points
BetMGM: Point Spread: Packers -8, Browns +8; Over/Under: 42 points
Season Record
Green Bay Packers: 2-0 (1st place, NFC North)
Cleveland Browns: 0-2 (4th place, AFC North)
Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the NFL on a 13-7 NFL RUN for +$5,470 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Green Bay Packers: won their last game at home against the Washington Commanders 27-18.
Cleveland Browns: lost their last game on the road against the Baltimore Ravens 41-17.
Green Bay Packers vs Cleveland Browns Preview and Analysis
The Packers are entering this game with a 2-0 record overall and they have a 1-0 record in their divisional games too. They are 2-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Washington Commanders 27-18. Jordan Love was the starting QB and he completed 19/31 passes for 292 passing yards, 2 touchdowns, and 0 interceptions. Josh Jacobs led the team in rushing yards with 84 and 1 TD. Tucker Kraft led the receivers with 124 receiving yards on 6 receptions and 1 TD. Edgerrin Cooper led the defense in that game with 7 solo tackles and 3 assisted tackles while Rashan Gary and Devonte Wyatt each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Browns are entering this game with a 0-2 record overall and they have a 0-2 record in their divisional games too. They are 0-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Baltimore Ravens 41-17. Joe Flacco was the starting QB and he completed 25/45 passes for 199 passing yards, 1 touchdown, and 1 interception. Quinshon Judkins led the team in rushing yards with 61. Jerry Jeudy led the receivers with 51 receiving yards on 4 receptions. Greg Newsome II led the defense in that game with 6 solo tackles and 1 assisted tackle while Myles Garrett led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.
Packers vs Browns Prediction
The current betting odds have the Packers listed as an 8.5 point favorite in this game according to Draftkings Sportsbook. The Packers have looked great in their games this season with their 2-0 record overall which has them right at the top of the NFC North. They beat down the Lions in week 1 with a 27-13 win and they are off a 27-18 win over the Commanders in their last one. They won that game at home by 9 points, but they were in complete control of that one as the score is much closer than the game actually was. They have had one of the best defenses in the NFL through 2 weeks and now they are going to have some extra rest for this first road game of the season since they played last Thursday. Meanwhile, the Browns haven't looked great in their games this season with their 0-2 record overall which has them right at the bottom of the AFC North. They almost pulled off the upset win over the Bengals in week 1, but they ended up losing with a missed FG and now they are off a terrible 41-17 loss to the Ravens in their last one. The defense hasn't looked terrible in their 2 games, but the offense hasn't scored more than 17 points in either game and they have struggled to move the ball. This is going to be one of the best defenses they face all season so this game against the Packers isn't going to go any better for this Browns offense. The Packers are going to roll right over the Browns and they won't even need to score much with their defense suffocating the Browns offense. The best way to place a bet here is on the Packers to cover the spread in this game.
Packers Browns Prediction: Our NFL Pick for Sunday, September 21, 2025 (1:00 pm ET start time) is Packers 28 Browns 6.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Green Bay Packers Cleveland Browns prediction, be sure to drop by every day for our weekly NFL predictions and previews.
NFL Betting Trends
Green Bay Packers: 22-15 ATS against AFC North division opponents. 18-10 ATS after playing a Thursday game. 14-8 ATS after 1 or more consecutive wins. 16-10 UNDER in games played on a grass field. 5-1 1H UNDER as a road favorite.
Cleveland Browns: 3-7 ATS in all games where the total is between 42.5 and 49 points. 4-8 ATS after playing a division game. 4-9 ATS after a game with a turnover margin of -2 or worse. 12-5 UNDER in home games.
Key Injuries
Green Bay Packers: Z. Anderson (S) Injured - Knee. A. Banks (OG) Injured - Groin. N. Hobbs (CB) Injured - Knee. J. Jacobs (RB) Injured - Ankle. J. Love (QB) Injured - Thumb. B. Melton (CB) Injured - Shoulder. J. Reed (WR) Injured - Foot. Z. Tom (OG) Injured - Oblique.
Cleveland Browns: D. Carter (WR) Injured - Concussion. M. Collins (DL) Injured - NIR-Rest. J. Conklin (OT) Injured - Elbow. G. Delpit (S) Injured - Back. M. Hall Jr. (DL) Injured - Knee. D. Ward (CB) Injured - Shoulder. J. Bitonio (OG) Injured - Back. C. Bojorquez (P) Injured - Ankle.
Notable Quotes
“It feels good. We couldn't have started the season off on a better note. It’s a thing we’ve just got to keep building on, but it feels great right now.” - Jordan Love after their win against the Commanders in their last game.
“We gave them 21 points via a blocked punt, a fumble recovery and an interception. It’s just hard to win. It’s hard to win, period, but it’s hard to win when you do that. We’ll own it.” - Kevin Stefanski after his team’s loss against the Ravens in their last game.
Starting Lineups
Green Bay Packers
WR Doubs, Romeo
WR Golden, Matthew
WR Wicks, Dontayvion
TE Kraft, Tucker
QB Love, Jordan
RB Jacobs, Josh
Cleveland Browns
WR Tillman, Cedric
WR Jeudy, Jerry
TE Njoku, David
TE Fannin Jr., Harold
QB Flacco, Joe
RB Judkins, Quinshon
Statistical Leaders
Green Bay Packers
Passing: J. Love (480)
Rushing: J. Jacobs (150)
Receiving: T. Kraft (140)
Touchdowns: J. Jacobs (2)
Cleveland Browns
Passing: J. Flacco (489)
Rushing: Q. Judkins (61)
Receiving: J. Jeudy (117)
Touchdowns: C. Tillman (2)
Coaches:
Green Bay Packers: Matt LaFleur (7th season)
Cleveland Browns: Kevin Stefanski (6th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
