by Rod Pearson
Friday, Oct 17, 2025
Game Time: 4:25 pm ET, Sunday, October 19, 2025
Venue: State Farm Stadium, Glendale, AZ
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Packers -7, Cardinals +7; Over/Under: 44.5 points
Bet365: Point Spread: Packers -6.5, Cardinals +6.5; Over/Under: 45 points
BetMGM: Point Spread: Packers -6.5, Cardinals +6.5; Over/Under: 45 points
Season Record
Green Bay Packers: 3-1-1 (1st place, NFC North)
Arizona Cardinals: 2-4 (4th place, NFC West)
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Recent Form
Green Bay Packers: won their last game at home against the Cincinnati Bengals 27-18.
Arizona Cardinals: lost their last game on the road against the Indianapolis Colts 31-27.
Green Bay Packers vs Arizona Cardinals Preview and Analysis
The Packers are entering this game with a 3-1-1 record overall and they have a 1-0 record in their divisional games too. They are 3-0 in their home games, 0-1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Cincinnati Bengals 27-18. Jordan Love was the starting QB and he completed 19/26 passes for 259 passing yards, 1 touchdown, and 1 interception. Josh Jacobs led the team in rushing yards with 93 and 2 TDs. Matthew Golden led the receivers with 86 receiving yards on 3 receptions. Quay Walker led the defense in that game with 5 solo tackles and 3 assisted tackles while Lukas Van Ness led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Cardinals are entering this game with a 2-4 record overall and they have a 0-2 record in their divisional games too. They are 1-2 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Indianapolis Colts 31-27. Jacoby Brissett was the starting QB and he completed 27/44 passes for 320 passing yards, 2 touchdowns, and 1 interception. Michael Carter led the team in rushing yards with 34. Zay Jones led the receivers with 79 receiving yards on 5 receptions. Mack Wilson Sr. led the defense in that game with 6 solo tackles and 3 assisted tackles while Baron Browning led the defense in sacks with 1. Mack Wilson Sr. came away with the only interception for them in that one.
Packers vs Cardinals Prediction
The current betting odds have the Packers listed as a 7 point favorite in this game according to Draftkings Sportsbook. The Packers have looked really good in their games this season with their 3-1-1 record overall which has them right at the top of the NFC North. They haven't looked great in their road games with all 3 of their wins coming at home, but they are off a 27-18 win over the Bengals coming off their bye week and they will be looking to go on a run now. Meanwhile, the Cardinals haven't looked good in their games this season with their 2-4 record overall which has them right at the bottom of the NFC West. They have had some really close losses, but nothing has gone their way so far and now they are dealing with a ton of injuries too. They have lost countless running backs over the last few weeks so their run game has taken a big hit and now they could be without Kyler Murray again. They didn't look bad last week with Jacoby Brissett taking over, losing on the road 31-27 to the Colts, and they were right in that game all day. They also put a lot of effort into winning that game though with Brissett facing his former team so they aren't going to come out with the same effort in this one. The Packers didn't look great against the Bengals, but they were in complete control of that game and they have a big opportunity to start stacking wins with a game against a really banged up Cardinals team. The best way to place a bet here is on the Packers to cover the spread in this game.
Packers Cardinals Prediction: Our NFL Pick for Sunday, October 19, 2025 (4:25 pm ET start time) is Packers 28 Cardinals 17.
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NFL Betting Trends
Green Bay Packers: 4-8 ATS as a favorite of 3.5 to 9.5 points. 3-6 ATS in a road game where the total is between 42.5 and 49 points. 2-9 ATS vs. poor passing defenses - allowing 235 or more passing yards/game. 9-4 OVER off a home win. 7-4 OVER as a favorite of 3.5 to 9.5 points.
Arizona Cardinals: 11-4 ATS as an underdog of 3.5 to 9.5 points. 8-4 ATS after allowing 30 points or more last game. 9-5 ATS off a road loss. 13-6 OVER in home games. 7-2 OVER after a loss by 6 or less points.
Key Injuries
Green Bay Packers: A. Belton (OT) Injured - Ankle. J. Jacobs (RB) Injured - Illness. A. Banks (OG) Injured - Groin. Z. Tom (OG) Injured - Oblique. D. Wyatt (DL) Injured - Knee. D. Wicks (WR) Injured - Ankle. L. Van Ness (DL) Injured - Foot. C. Watson (WR) Injured - Knee. J. Monk (OG) Injured - Hamstring. B. McManus (K) Injured - Quadricep. J. Morgan (OT) Injured - Knee. W. Brinson (DL) Injured - Abdomen. M. Golden (WR) Injured - Shoulder. J. Bullard (S) Injured - Concussion.
Arizona Cardinals: W. Nolen III (DL) Injured - Calf. K. Beachum (OG) Injured - NIR-Rest. Z. Jones (WR) Injured - Knee. K. Murray (QB) Injured - Foot. D. Hall (CB) Injured - Quadricep. A. Davis-Gaither (LB) Injured - Foot. E. Demercado (RB) Injured - Ankle. M. Wilson (WR) Injured - Foot. B. Knight (RB) Injured - Knee. M. Harrison Jr. (WR) Injured - Concussion. D. Robinson (DL) Injured - Pectoral. D. Taylor-Demerson (S) Injured - Ankle. K. Crawford (S) Injured - Ankle. B. Nichols (DL) Injured - NIR - Personal.
Notable Quotes
“I feel a sense of relief right now. We always try to take it one game at a time. The bottom line is you've got to find a way to win the game. And you see each and every week around the league, a lot of these games are going down to the wire.” - Matt LaFleur after his team’s win against the Bengals in their last game.
“We had some good (defensive) concepts, I liked what we did at times. But we gave Taylor way too much.” - Jonathan Gannon after his team’s loss against the Colts in their last game.
Starting Lineups
Green Bay Packers
WR Doubs, Romeo
WR Golden, Matthew
WR Wicks, Dontayvion
TE Kraft, Tucker
QB Love, Jordan
RB Jacobs, Josh
Arizona Cardinals
WR Fehoko, Simi
WR Jones, Zay
WR Wilson, Michael
TE McBride, Trey
QB Brissett, Jacoby
RB Knight, Bam
Statistical Leaders
Green Bay Packers
Passing: Jordan Love (1,259)
Rushing: Josh Jacobs (359)
Receiving: Tucker Kraft (268)
Touchdowns: Josh Jacobs (6)
Arizona Cardinals
Passing: Kyler Murray (962)
Rushing: Kyler Murray (173)
Receiving: Trey McBride (347)
Touchdowns: James Conner (2)
Coaches:
Green Bay Packers: Matt LaFleur (7th season)
Arizona Cardinals: Jonathan Gannon (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
