Florida Gators vs LSU Tigers Prediction, Picks and Game Preview - 09/13/2025

Game Time: 7:30 pm ET, Saturday, September 13, 2025

Venue:  Tiger Stadium, Baton Rouge, LA 

Where to Watch:  ABC

DraftKings:  Point Spread:  Florida +7.5, LSU -7.5; Over/Under:  47.5 points

Bet365:  Point Spread:  Florida +7.5, LSU -7.5; Over/Under:  47.5 points

BetMGM:  Point Spread:  Florida +7.5, LSU -7.5; Over/Under:  47.5 points

Florida Gators:  1-1 (0-0) (14th place, SEC)

LSU Tigers:  2-0 (0-0) (12th place, SEC)

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Florida Gators:  lost their last game at home against the South Florida Bulls 18-16.

LSU Tigers:  won their last game at home against the Louisiana Tech Bulldogs 23-7.

Florida is entering this game with a 1-1 record overall and they have a 0-0 record in their conference games too. They are 1-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against South Florida 18-16. DJ Lagway was the starting QB and he completed 23/33 passes for 222 passing yards, 1 touchdown, and 1 interception. Jadan Baugh led the team in rushing yards with 93. Eugene Wilson III led the receivers with 60 receiving yards on 7 receptions and 1 TD. Jaden Robinson led the defense in that game with 4 solo tackles and 5 assisted tackles while Tyreak Sapp led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

LSU is entering this game with a 2-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Louisiana Tech 23-7. Garrett Nussmeier was the starting QB and he completed 26/41 passes for 237 passing yards, 1 touchdown, and 1 interception. Harlem Berry led the team in rushing yards with 56. Barion Brown led the receivers with 94 receiving yards on 8 receptions. West Weeks led the defense in that game with 4 solo tackles and 6 assisted tackles while West Weeks, Whit Weeks, Jack Pyburn, and Jardin Gilbert each led the defense in sacks with 0.5. No one on the defense came away with an interception for them in that one.

The current betting odds have LSU listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. LSU has a 2-0 record overall this season and they have looked really good in their 2 games so far. They are off a 23-7 win over LA Tech in their last one and their offense didn't look great as they struggled to get going, but the defense only gave up 7 points and has shown a ton of improvement this year. They were also great in their season opener which was a nice 17-10 win over Clemson on the road, and they could have made that game look a lot worse than it was. Meanwhile, Florida has a 1-1 record overall this season and they haven't looked great in their games. They opened the season with a cupcake, beating up on LIU at home, but now they are off a loss in their last one. They lost at home to an in-state rival, losing 18-16 to South Florida, and as good as South Florida has looked in their first 2 games, they still don't have the talent that Florida has. This LSU team has a lot more talent though and DJ Lagway hasn't looked good in this offense in either game so this is a really tough game for them to start the conference schedule on the road. Florida will struggle to move the ball on this LSU defense, and LSU has a lot more talent on offense to get the job done at home. This is a big year for LSU too, finally getting over the opening game hump, so they are going to bring their best effort for this first conference game of the season at home. The best way to place a bet here is on LSU to cover the spread in this game. 

Florida LSU Prediction:  Our NCAAF Pick for Saturday, September 13, 2025 (7:30 pm ET start time) is LSU 24 Florida 10.

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Florida Gators: 2-7 ATS when the total is between 42.5 and 49. 1-3 ATS as an underdog of 3.5 to 10 points. 3-6 ATS in the first month of the season. 6-3 OVER in road lined games. 12-4 OVER against conference opponents. 8-3 OVER after 1 or more consecutive straight up losses.

LSU Tigers: 8-4 ATS off a home win. 5-0 ATS at home after playing a game at home. 6-3 ATS at home after 1 or more consecutive straight up wins. 11-5 OVER against conference opponents. 12-6 OVER after 1 or more consecutive straight up wins. 

Florida Gators:  F. Westphal (OG) Out - Undisclosed. S. Isacks (TE) Out - Undisclosed. M. Caraway Jr. (CB) Out - Undisclosed. L. McCray (DL) Out - Undisclosed. D. Wilson (WR) Out - Leg. T. Webb (RB) Out - Undisclosed. K. Jackson (WR) Out - Knee.

LSU Tigers:  B. Moore (OG) Questionable - Ankle. D. Hill (WR) Questionable - Hand. Z. Williams (DL) Out - Undisclosed. T. Green (TE) Questionable - Knee. J. Lindsey (RB) Out - Suspension.

“We created it. We deserve it. If you play football like that, you’re going to be criticized. It comes with the territory, right? Only thing you can do is go get it fixed, and that’s what we’ll start working on (Sunday).” - Billy Napier after his team’s loss against USF in their last game. 

“We’re not happy with production across the board. I’m not happy with the performance, but it’s a win.” - Brian Kelly after his team’s win against LA Tech in their last game. 

WR Sturdivant, J. Michael

WR Mizell, Aidan

WR Wilson III, Eugene

TE Hansen, Hayden

QB Lagway, DJ

RB Baugh, Jadan

WR Thomas, Zavion

WR Anderson, Aaron

WR Hilton Jr., Chris

TE Sharp, Bauer

QB Nussmeier, Garrett

RB Durham, Caden

Passing: D. Lagway (342)

Rushing: J. Baugh (197)

Receiving: V. Brown III (135)

Touchdowns: E. Wilson III (2)

Passing: G. Nussmeier (469)

Rushing: C. Durham (103)

Receiving: A. Anderson (172)

Touchdowns: C. Durham (2)

Coaches:

Florida Gators: Billy Napier (4th season)

LSU Tigers: Brian Kelly (4th season)