Duke Blue Devils vs Michigan State Spartans Prediction, Picks and Game Preview - 11/10/2026

Game Time: 7:00 pm ET, Tuesday, November 10, 2026

Venue:  United Center, Chicago, IL

Where to Watch:  ESPN

DraftKings:  Point Spread:  MSU +6.5, Duke -6.5; Over/Under:  148.5 points

Bet365:  Point Spread:  MSU +6.5, Duke -6.5; Over/Under:  148.5 points

BetMGM:  Point Spread:  MSU +6.5, Duke -6.5; Over/Under:  148.5 points

Duke Blue Devils:  2-0 (0-0) (3rd place, ACC)

Michigan State Spartans:  2-0 (0-0) (1st place, Big Ten)

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Duke Blue Devils:  2-0  last 2

Michigan State Spartans:  2-0  last 2

Duke is entering this game with a 2-0 record overall, a 0-0 record in conference games, and they are 0-0 in their neutral site games this season where they will be in this game. They are coming off a win against the Coastal Carolina Chanticleers in their last game. Patrick Ngongba II led the team in points in that game with 28 while John Blackwell and Caleb Foster each were next on the team with 15. Cayden Boozer led the team in assists with 12 in that game while Sebastian Wilkins led the team in rebounds with 11. They were 61.3% from the field, 50% from 3-point range, and 63.4% from the free throw line with their shooting in that game. Their offense is averaging 98.5 PPG and their defense is allowing their opponents to average 51 PPG against them. Duke has an ATS record of 1-1 this season and their O/U record is 1-1.

Michigan State is entering this game with a 2-0 record overall, a 0-0 conference record, and they are 0-0 in their neutral site games this season where they will be in this game. They are coming off a win against the Toledo Rockets in their last game. Jasiah Jervis led the team in points in that game with 16 while Jordan Scott and Jeremy Fears Jr. each were next on the team with 12. Jeremy Fears Jr. led the team in assists with 9 in that game while Jordan Scott led the team in rebounds with 9. They were 50.9% from the field, 41.7% from 3-point range, and 60.5% from the free throw line with their shooting in that game. Their offense is averaging 93.5 PPG and their defense is allowing their opponents to average 60 PPG against them. Michigan State has an ATS record of 2-0 this season and their O/U record is 1-1.

The current betting odds have Michigan State listed as a 6.5 point underdog in this game according to Draftkings Sportsbook. Michigan State has looked good in their games this season with their 2-0 record overall. They are coming off a big win over Toledo in their last one and they haven't really been challenged yet this season, but this game is at a neutral site so they will be in a better environment than it being a road game. They are currently ranked inside the top 5 and they have a lot of returning talent from last season. They had a really good season last year and will be looking to build on that this year with an improved team. Meanwhile, Duke has looked good in their games this season with their 2-0 record overall. They are coming off a win over Coastal Carolina in their last one and they have been blowing teams out, but they haven't really been challenged yet either. Unlike Michigan State, Duke did lose a lot of their talent from last season. Duke has had one of the best teams in the nation over the last 3 years, but they have also had some really good players come through and go straight to the NBA. They still have one of the best teams in the nation this season, but they don't have as talented a team as they have had in previous years. Duke has also had trouble winning tight games as a lot of their wins over the last 3 years have been blow outs, but they tend to get tight when the game is close and that is a big reason why they haven't won a National Championship with Scheyer yet despite having such great teams. Michigan State always has a great defensive team under Izzo and they have the talent to be right in this game until the end. The best way to place a bet here is on Michigan State to cover the spread in this game. 

Duke Michigan State Prediction:  Our NCAAB Pick for Tuesday, November 10, 2026 (7:00 pm ET start time) is Duke 75 Michigan State 72.

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Duke Blue Devils: 22-14 ATS when the total is 140 to 149.5. 17-10 ATS after a win by 15 points or more. 8-3 ATS after playing 2 consecutive home games. 11-4 UNDER as an underdog. 25-12 UNDER when the total is 140 to 149.5. 23-5 UNDER after a win by 15 points or more.

Michigan State Spartans: 27-44 ATS at home after a game where they made 55% of their shots or better. 22-13 UNDER in non-conference games. 18-12 UNDER after scoring 85 points or more. 9-2 UNDER after playing 2 consecutive home games.

Duke Blue Devils:  None.

Michigan State Spartans:  None.

“It’s part of the reason we played the exhibition schedule we did. We wanted to be tested in different ways. There’s no question Michigan State is going to test us in ways we haven’t seen yet. We know it’s going to be a tough game but it’s also what we signed up for. We want to be in moments like this and games like this. We’ll be ready for a great one. And in a great city, by the way.” - Jon Scheyer after his team’s win against CCU in their last game. 

“I was disappointed, and that takes nothing away from Toledo. I did feel they played hard and physical. I just don’t think we’re playing as hard or as physical. Too many dribble drives, too many guys going around guys.” - Tom Izzo after his team’s win against Toledo in their last game. 

J. Blackwell 

C. Boozer 

J. Boumtje Boumtje 

P. Ngongba 

D. Sarr

A. Bonke 

C. Carr 

J. Fears 

J. Jervis

J. Scott

PPG: Patrick Ngongba II (19)

APG: Cayden Boozer (7.5)

Reb/G: Patrick Ngongba II (8)

PPG: Jeremy Fears Jr. (12.5)

APG: Jeremy Fears Jr. (10)

Reb/G: Anton Bonke (10)

Coaches:

Duke Blue Devils: Jon Scheyer (5th season)

Michigan State Spartans: Tom Izzo (32nd season)