Detroit Tigers vs Seattle Mariners Prediction, Preview and Odds - 10/10/2025

Game Time: 8:08 pm ET, Friday, October 10, 2025

Venue:  T-Mobile Park, Seattle, WA

Where to Watch:  FOX

DraftKings:  Moneyline odds:  Tigers -143, Mariners +118; Over/Under:  6 runs

Bet365:  Moneyline odds:  Tigers -140, Mariners +120; Over/Under:  6 runs

BetMGM:  Moneyline odds:  Tigers -140, Mariners +120; Over/Under:  5.5 runs

Detroit Tigers:  87-75 (2nd place, AL Central)

Seattle Mariners:  90-72 (1st place, AL West)

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Detroit Tigers:  5-5 last 10

Seattle Mariners:  5-5 last 10

The Tigers are entering this series off a win and won their best of 3-game series against the Cleveland Guardians 2-1 in the American League Wild Card. They finished the regular season with an 87-75 record overall and had a road record of 41-40. This is the series finale of a best 3 out of 5 game series with the Mariners on Friday for the American League Division Series. The Tigers won the series opener on Saturday, lost the 2nd game on Sunday, lost the 3rd game on Tuesday, and won the 4th game on Wednesday. Their offense ranks 12th in the MLB with a .729 OPS. Casey Mize was their starting pitcher on Wednesday while Tarik Skubal is making his start in this game on Friday. He is 13-6 with a 2.21 ERA this season. His team lost 4 of their last 5 games this season with him making an appearance. In his last MLB start, he allowed 2 ER, 2 HR, and 1 BB with 9 Ks on 5 hits through 7 IP against the Seattle Mariners.

The Mariners are entering this series off a loss and got swept in their 3-game series against the Los Angeles Dodgers 3-0 to end the regular season. They finished the regular season with a 90-72 record overall and had a home record of 51-30. This is the 5th game of a best 3 out of 5 game series with the Tigers on Friday for the ALDS. The Mariners lost the 1st game of this series on Saturday, won the 2nd game on Sunday, won the 3rd game on Tuesday, and lost the 4th game on Wednesday. Their offense ranks 10th in the MLB with a .740 OPS. Bryce Miller was their starting pitcher on Wednesday while George Kirby is making his start in this game on Friday. He is 10-8 with a 4.21 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB start, he allowed 2 earned runs, 1 homer, and 1 BB with 8 strikeouts on 6 hits through 5 innings played against the Detroit Tigers.

The current betting odds have the Tigers listed as a favorite in this game according to Draftkings Sportsbook. The Tigers took game 4 of this series on Wednesday and were able to force this final game in Seattle. The Mariners have the home advantage for this last game in the series, but the Tigers do have the pitching advantage here. Skubal is on the mound for the Tigers in this one and he has looked great all season. He is 13-6 with a 2.21 ERA and he hasn't been giving up many runs in the playoffs. His team has been struggling with him lately, losing 4 of the last 5 games he started in, but he only gave up 2 earned runs in his last start and has been great in these playoffs. Meanwhile, the Mariners are going with Kirby in this one and he hasn't looked great this season. He hasn't been giving up a ton of runs lately, but he is 10-8 with a 4.21 ERA and can't be trusted in this game. The Mariners have also lost 2 games in a row now with him starting and even though he only gave up 2 earned runs in his last start, the Mariners still lost that game at home to the Tigers. The Mariners had the Tigers on the ropes in game 4, even taking a 3-0 lead, but they gave the Tigers hope and now the tables have turned since the Tigers have a big pitching advantage going into this final game. The Mariners had their chance to close the series out in Detroit and couldn't do it, look for the Tigers to finish the job now. The best way to place a bet here is on the Tigers to win this game. 

Tigers Mariners Prediction:  Our MLB Pick for Friday, October 10, 2025 (8:08 pm ET start time) is Tigers 3 Mariners 1.

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Detroit Tigers: 259-242 (+18.4 units) on the moneyline in all games. 131-123 (+25.5 units) on the moneyline in road games. 75-46 (+8.8 units) on the moneyline as a favorite of -125 to -175. 21-13 OVER against AL West opponents.

Seattle Mariners: 265-225 (-6.2 units) on the moneyline in all games. 54-72 (-7.3 units) on the moneyline as an underdog of +100 to +150. 127-125 (-5.4 units) on the moneyline when playing against a team with a winning record. 16-7 OVER vs. a starting pitcher whose winning percentage is better than 70%.

Detroit Tigers:  B. Brieske (RP) Sixty Day IL - Forearm. S. Gipson-Long (SP) Fifteen Day IL - Neck. M. Vierling (CF) Ten Day IL - Oblique. R. Olson (SP) Sixty Day IL - Shoulder. S. Guenther (RP) Sixty Day IL - Hip. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. T. Madden (SP) Sixty Day IL - Shoulder.

Seattle Mariners:  B. Woo (SP) Day To Day - Pectoral. J. Kowar (RP) Fifteen Day IL - Shoulder. T. Thornton (RP) Sixty Day IL - Achilles. G. Santos (RP) Sixty Day IL - Knee. R. Bliss (2B) Sixty Day IL - Biceps.

“The best chance for us to not only keep this game close but win this game was to continue to throw different pitchers at them. It's been a successful strategy for us. Casey definitely could have gone out [for the fourth], but when the game dropped us off at [Mariners first baseman Josh Naylor] and we have our full allotment in the 'pen … we were all hands on deck. And so the aggressive move to the 'pen was to try to give them a lot of different looks.” - A.J. Hinch after his team’s win against the Mariners in game 4 of this series on Wednesday.

“They were able to get a couple guys on. It just felt like the right time to go get [lefty] Gabe [Speier] and be ready for that left-handed pocket coming up.” - Dan Wilson after his team’s loss against the Tigers in game 4 of this series on Wednesday.

Randy Arozarena (R) LF

Cal Raleigh (S) C

Julio Rodríguez (R) CF

Jorge Polanco (S) 2B

Josh Naylor (L) 1B

Eugenio Suárez (R) 3B

Dominic Canzone (L) DH

Victor Robles (R) RF

J.P. Crawford (L) SS

Kerry Carpenter (L) RF

Gleyber Torres (R) 2B

Colt Keith (L) DH

Riley Greene (L) LF

Spencer Torkelson (R) 1B

Zach McKinstry (L) 3B

Dillon Dingler (R) C

Parker Meadows (L) CF

Javier Báez (R) SS

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (155)

Home Runs:  Riley Greene (36)

RBI:  Riley Greene (111)

Stolen Bases:  Zach McKinstry (19)

Wins:  Casey Mize (14)

Saves:  Will Vest (23)

ERA:  Alex Lange (0.00)

Batting Average:  Dominic Canzone (.300)

Hits:  Julio Rodríguez (174)

Home Runs:  Cal Raleigh (60)

RBI:  Cal Raleigh (125)

Stolen Bases:  Randy Arozarena (31)

Wins:  Bryan Woo (15)

Saves:  Andrés Muñoz (38)

ERA:  Jhonathan Díaz (0.00)

Managers:

Detroit Tigers: A.J. Hinch (5th season)

Seattle Mariners: Dan Wilson (2nd season)