Detroit Tigers vs New York Yankees Prediction, Preview and Odds - 09/11/2025

Game Time: 7:05 pm ET, Thursday, September 11, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  FDSD, YES

DraftKings:  Moneyline odds:  Tigers +123, Yankees -150; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Tigers +125, Yankees -150; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Tigers +125, Yankees -150; Over/Under:  8.5 runs

Detroit Tigers:  83-62 (1st place, AL Central)

New York Yankees:  80-64 (2nd place, AL East)

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Detroit Tigers:  5-5 last 10

New York Yankees:  6-4 last 10

The Tigers are entering this series off a loss and lost their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with an 83-62 record overall and have a road record of 37-33. This is the series finale of a 3-game series with the Yankees on Thursday with the 2nd game still to be played on Wednesday. The Tigers won the series opener on Tuesday. Their offense ranks 11th in the MLB with a .740 OPS. Jack Flaherty is their starting pitcher on Wednesday while Tyler Holton is making his start in this game on Thursday. He is 5-4 with a 3.80 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 0 BB with 1 SO on 1 hit through 1 IP against the New York Yankees.

The Yankees are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with an 80-64 record overall and have a home record of 43-30. This is the 3rd game of a 3-game series with the Tigers on Thursday with the 2nd game of this series still to be played on Wednesday. The Yankees lost the 1st game of this series on Tuesday. Their offense ranks 1st in the MLB with a .782 OPS. Carlos Rodón is their starting pitcher on Wednesday while rookie pitcher Cam Schlittler is making his start in this game on Thursday. He is 2-3 with a 3.24 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 0 homers, and 2 walks with 2 strikeouts on 5 hits through 1.2 innings pitched against the Toronto Blue Jays.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Tigers have looked great in their games this season with their 83-62 record overall which has them right at the top of the AL Central with one of the best records in the entire MLB. They have been a good road team too with their 37-33 road record this season. Meanwhile, the Yankees have looked really good in their games this season with their 80-64 record overall which has them right near the top of the AL East. They have also looked great in their own ballpark this year with their 43-30 home record. The Yankees have been the hotter team lately too, going 6-4 in their last 10 games while the Tigers are 4-6. Schlittler is starting for the Yankees in this one and he has looked good this season. He is 2-3 with a 3.24 ERA and has looked a lot better lately as he gets settled into his rookie season. He did give up 4 earned runs in his last start, but he will be looking to bounce back at home. The team has also won 3 of their last 4 games with him starting and they have one of the best offenses in the MLB to help him out too. The Tigers aren't going to have one of their aces on the mound here so that gives the Yankees a big edge at home with the Tigers not playing at their best lately either. The best way to place a bet here is on the Yankees to win this game. 

Tigers Yankees Prediction:  Our MLB Pick for Thursday, September 11, 2025 (7:05 pm ET start time) is Yankees 6 Tigers 4.

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Detroit Tigers: 251-226 (+29.1 units) on the moneyline in all games. 124-114 (+27.6 units) on the moneyline in road games. 90-176 (+15.5 units) on the moneyline against right-handed starters. 29-18 OVER vs. a team with a poor bullpen whose ERA is 4.20 or worse.

New York Yankees: 263-218 (-27.4 units) on the moneyline in all games. 133-109 (-29.3 units) on the moneyline in home games. 172-136 (-10.8 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 41-29 OVER when playing against a team with a winning record.

Detroit Tigers:  Z. McKinstry (3B) Day To Day - Back. K. Finnegan (RP) Fifteen Day IL - Abductor. M. Vierling (CF) Ten Day IL - Oblique. P. Sewald (RP) Sixty Day IL - Shoulder. R. Olson (SP) Sixty Day IL - Shoulder. S. Guenther (RP) Sixty Day IL - Hip. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. T. Madden (SP) Sixty Day IL - Shoulder. J. Urquidy (SP) Sixty Day IL - Elbow.

New York Yankees:  B. Headrick (RP) Fifteen Day IL - Forearm. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

“Just really good at-bats. We put nine at-bats in a row that were extremely good. Some of them were hits, some of them were walks and some pressure points where we could really push them to make some pitches. So I was really proud of our guys.” - A.J. Hinch after his team’s win against the Yankees in their game on Tuesday.

“It got away from us. It’s not like we got hit a lot all over the yard; just some balls finding some holes, but too many free passes.” - Aaron Boone after his team’s loss against the Tigers in their game on Tuesday.

Colt Keith (L) 3B

Gleyber Torres (R) 2B

Kerry Carpenter (L) DH

Riley Greene (L) LF

Spencer Torkelson (R) 1B

Wenceel Pérez (S) RF

Parker Meadows (L) CF

Dillon Dingler (R) C

Trey Sweeney (L) SS

Trent Grisham (L) CF

Aaron Judge (R) DH

Cody Bellinger (L) LF

Ben Rice (L) 1B

Giancarlo Stanton (R) RF

Jazz Chisholm Jr. (L) 2B

Austin Wells (L) C

José Caballero (R) SS

Ryan McMahon (L) 3B

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (145)

Home Runs:  Riley Greene (32)

RBI:  Riley Greene (104)

Stolen Bases:  Zach McKinstry (19)

Wins:  Casey Mize (14)

Saves:  Will Vest (20)

ERA:  Kyle Finnegan (0.00)

Batting Average:  Amed Rosario (.389)

Hits:  Aaron Judge (155)

Home Runs:  Aaron Judge (44)

RBI:  Aaron Judge (98)

Stolen Bases:  Jazz Chisholm (27)

Wins:  Carlos Rodón (16)

Saves:  Devin Williams (18)

ERA:  Adam Ottavino (0.00)

Managers:

Detroit Tigers: A.J. Hinch (5th season)

New York Yankees: Aaron Boone (8th season)