Detroit Tigers vs New York Yankees Prediction, Preview and Odds - 09/10/2025

Game Time: 7:05 pm ET, Wednesday, September 10, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB Network, Prime Video

DraftKings:  Moneyline odds:  Tigers +140, Yankees -172; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Tigers +140, Yankees -170; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Tigers +140, Yankees -170; Over/Under:  8.5 runs

Detroit Tigers:  82-62 (1st place, AL Central)

New York Yankees:  80-63 (2nd place, AL East)

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Detroit Tigers:  4-6 last 10

New York Yankees:  7-3 last 10

The Tigers are entering this series off a loss and lost their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with an 82-62 record overall and have a road record of 36-33. This is the 2nd game of a 3-game series with the Yankees on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 10th in the MLB with a .740 OPS. Casey Mize is their starting pitcher on Tuesday while Jack Flaherty is making his start in this game on Wednesday. He is 7-13 with a 4.85 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 0 HR, and 2 BB with 2 SO on 6 hits through 4.1 IP against the Chicago White Sox.

The Yankees are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with an 80-63 record overall and have a home record of 43-29. This is the 2nd game of a 3-game series with the Tigers on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 1st in the MLB with a .784 OPS. Will Warren is their starting pitcher on Tuesday while Carlos Rodón is making his start in this game on Wednesday. He is 16-7 with a 3.12 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 2 walks with 3 strikeouts on 3 hits through 6 innings pitched against the Houston Astros.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Tigers have looked great in their games this season with their 82-62 record overall which has them right at the top of the AL Central with one of the best records in the entire MLB. They have been a good road team too with their 36-33 road record this season. Meanwhile, the Yankees have looked really good in their games this season with their 80-63 record overall which has them right near the top of the AL East. They have also looked great in their own ballpark this year with their 43-29 home record. The Yankees have also been rolling in their games lately as they are 7-3 in their last 10 games while the Tigers are only 4-6, and the Yankees do have the better pitching matchup in this one too. The Yankees are going with Rodon in this one and he has looked great this year. He is 16-7 with a 3.12 ERA and leads the team in wins this year. He hasn't been giving up many runs lately either, only giving up 1 earned run in his last start which has been a common theme for him all year. The team has also had a ton of success with him starting, winning 6 games in a row now with him on the mound. The Tigers are going with Flaherty in this one and he hasn't looked great this season. He is 7-13 with a 4.85 ERA and has been giving up quite a few runs lately. He is coming off another bad start in which he gave up 4 earned runs and the team hasn't had much success with him lately either, losing 3 games in a row now with him on the mound. Both of these teams have had great pitching staffs all season, but the Yankees do have the edge at home with Rodon starting. The best way to place a bet here is on the Yankees to win this game. 

Tigers Yankees Prediction:  Our MLB Pick for Wednesday, September 10, 2025 (7:05 pm ET start time) is Yankees 7 Tigers 1.

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Detroit Tigers: 250-226 (+27.7 units) on the moneyline in all games. 123-114 (+26.2 units) on the moneyline in road games. 111-140 (+11.6 units) on the moneyline as an underdog of +100 or higher. 28-18 OVER vs. a team with a poor bullpen whose ERA is 4.20 or worse.

New York Yankees: 263-217 (-25.9 units) on the moneyline in all games. 133-108 (-27.8 units) on the moneyline in home games. 199-153 (-37.4 units) on the moneyline as a favorite of -110 or higher. 40-29 OVER when playing against a team with a winning record.

Detroit Tigers:  K. Finnegan (RP) Fifteen Day IL - Abductor. M. Vierling (CF) Ten Day IL - Oblique. P. Sewald (RP) Sixty Day IL - Shoulder. R. Olson (SP) Sixty Day IL - Shoulder. S. Guenther (RP) Sixty Day IL - Hip. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. T. Madden (SP) Sixty Day IL - Shoulder. J. Urquidy (SP) Sixty Day IL - Elbow.

New York Yankees:  B. Headrick (RP) Fifteen Day IL - Forearm. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

“Ten free passes, either by a walk or a hit-by-pitch. We thought we were getting away with it for a while, and then in the end we couldn’t. It’s just more opportunities as more guys roll in the lineup, kinda got to deal with the top of their lineup. Again, it just wasn’t a good day on the mound for us with the free passes.” - A.J. Hinch after his team’s loss against the White Sox in their game on Sunday.

“He really buckled down. To get us seven innings [when] we were a little short at the back today, I thought it was a really good effort.” - Aaron Boone after his team’s win against the Blue Jays in their game on Sunday.

Gleyber Torres (R) 2B

Kerry Carpenter (L) LF

Riley Greene (L) DH

Spencer Torkelson (R) 1B

Wenceel Pérez (S) RF

Colt Keith (L) 3B

Zach McKinstry (L) SS

Jake Rogers (R) C

Parker Meadows (L) CF

Trent Grisham (L) CF

Aaron Judge (R) RF

Cody Bellinger (L) LF

Ben Rice (L) 1B

Giancarlo Stanton (R) DH

Jazz Chisholm Jr. (L) 2B

Austin Wells (L) C

Anthony Volpe (R) SS

Ryan McMahon (L) 3B

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (143)

Home Runs:  Riley Greene (32)

RBI:  Riley Greene (103)

Stolen Bases:  Zach McKinstry (19)

Wins:  Casey Mize (13)

Saves:  Will Vest (20)

ERA:  Kyle Finnegan (0.00)

Batting Average:  Amed Rosario (.389)

Hits:  Aaron Judge (154)

Home Runs:  Aaron Judge (43)

RBI:  Aaron Judge (97)

Stolen Bases:  Jazz Chisholm (27)

Wins:  Carlos Rodón (16)

Saves:  Devin Williams (18)

ERA:  Adam Ottavino (0.00)

Managers:

Detroit Tigers: A.J. Hinch (5th season)

New York Yankees: Aaron Boone (8th season)