Detroit Tigers vs Boston Red Sox Prediction, Preview and Odds - 09/26/2025

Game Time: 7:10 pm ET, Friday, September 26, 2025

Venue:  Fenway Park, Boston, MA

Where to Watch:  Apple TV+

DraftKings:  Moneyline odds:  Tigers +101, Red Sox -123; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Tigers +100, Red Sox -120; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Tigers +100, Red Sox -120; Over/Under:  8.5 runs

Detroit Tigers:  85-73 (2nd place, AL Central)

Boston Red Sox:  87-71 (3rd place, AL East)

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Detroit Tigers:  1-9 last 10

Boston Red Sox:  6-4 last 10

The Tigers got swept in their 3-game series against the Atlanta Braves 3-0. They enter this game with an 85-73 record overall and have a road record of 39-38. This is the series opener of a 3-game series with the Red Sox on Friday with the series finale of their series against the Cleveland Guardians still to be played on Thursday. The Tigers lost the series opener on Tuesday and the 2nd game on Wednesday. Their offense ranks 12th in the MLB with a .731 OPS. Troy Melton is their starting pitcher on Thursday while Casey Mize is making his start in this game on Friday. He is 14-6 with a 3.91 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 1 HR, and 3 BB with 5 SO on 5 hits through 5.2 IP against the Atlanta Braves.

The Red Sox won their 3-game series against the Tampa Bay Rays 2-1. They enter this game with an 87-71 record overall and have a home record of 46-32. This is the 1st game of a 3-game series with the Tigers on Friday with the 3rd game of their series against the Toronto Blue Jays still to be played on Thursday. The Red Sox won the 1st game of this series on Tuesday and the 2nd game on Wednesday. Their offense ranks 8th in the MLB with a .748 OPS. Brayan Bello is their starting pitcher on Thursday while Kyle Harrison is making his start in this game on Friday. He is 1-1 with a 3.58 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 2 walks with 5 strikeouts on 4 hits through 6 innings pitched against the Tampa Bay Rays.

The current betting odds have the Red Sox listed as a slight favorite in this game according to Draftkings Sportsbook. The Red Sox have looked really good in their games this season with their 87-71 record overall which has them right in the middle of the AL East and in a Wild Card spot. They have looked great in their own ballpark too with their 46-32 home record this year. Meanwhile, the Tigers have looked really good in their games this season with their 85-73 record overall which has them right near the top of the AL Central. They haven't been a good road team though with their 39-38 road record this year. The Tigers were one of the best teams in the MLB at one point in the season, but now they have played themselves into a position where they could miss the playoffs altogether. They have looked terrible lately as they are 1-9 in their last 10 games, and the Red Sox have been getting hot with their 6-4 record in their last 10 games, still needing to clinch a playoff spot too. Harrison is on the mound for the Red Sox in this one and he has looked good this year. He is 1-1 with a 3.58 ERA and the team has been having a ton of success with him lately. He is coming off a good start in which he gave up 1 earned run and the team has won 4 of their last 5 games with him starting too. The Tigers are going with Mize in this one and he has looked good this season too. He is 14-6 with a 3.91 ERA, but lately he hasn't looked great. He gave up 3 earned runs in his last start which is starting to become a common theme for him, and the team has lost 2 games in a row now with him starting too. The Tigers are slumping at the worst possible time and all signs point to the Red Sox in this one. The best way to place a bet here is on the Red Sox to win this game. 

Tigers Red Sox Prediction:  Our MLB Pick for Friday, September 26, 2025 (7:10 pm ET start time) is Red Sox 7 Tigers 2.

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Detroit Tigers: 253-237 (+16.5 units) on the moneyline in all games. 126-119 (+23.6 units) on the moneyline in road games. 108-115 (+8.8 units) on the moneyline when playing against a team with a winning record. 30-19 OVER on the road when playing against a good team (Win Pct. 54% to 62%). 

Boston Red Sox: 245-236 (-10.5 units) on the moneyline in all games. 122-117 (-23.3 units) on the moneyline in home games. 181-171 (-5.9 units) on the moneyline against right-handed starters. 12-6 OVER revenging a same season 3 game sweep at the hands of their opponents.

Detroit Tigers:  J. Baez (CF) Day To Day - Neck. C. Keith (2B) Ten Day IL - Rib Cage. B. Brieske (RP) Sixty Day IL - Forearm. S. Gipson-Long (SP) Fifteen Day IL - Neck. M. Vierling (CF) Ten Day IL - Oblique. R. Olson (SP) Sixty Day IL - Shoulder. S. Guenther (RP) Sixty Day IL - Hip. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. T. Madden (SP) Sixty Day IL - Shoulder.

Boston Red Sox:  B. Bernardino (RP) Fifteen Day IL - Lat. V. Grissom (2B) Sixty Day IL - Foot. D. May (SP) Fifteen Day IL - Elbow. J. Hicks (RP) Fifteen Day IL - Shoulder. R. Anthony (RF) Ten Day IL - Oblique. M. Mayer (3B) Sixty Day IL - Wrist. R. Fitts (SP) Fifteen Day IL - Biceps. L. Guerrero (RP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Flexor. H. Dobbins (SP) Sixty Day IL - ACL. L. Hendriks (RP) Sixty Day IL - Hip. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. P. Sandoval (SP) Sixty Day IL - Elbow.

“They made some incredible defensive plays because they’re a good team. They’re making winning plays, and we kept coming at them. And even what I thought was going to be a sac fly carries out of the ballpark, and it’s a 2-1 game, there’s still a lot of life in the dugout and a lot to play for. But the at-bats get a little bit quicker, and the at-bats get a little bit tougher, and then they start matching up, and they have an elite 'pen and they get their outs. It’s a combination of things, but it certainly doesn’t feel good. And when you’re going through the games that we’re going through, it’s obviously impacting a lot of people.” - A.J. Hinch after his team’s loss against the Guardians in their game on Wednesday.

“It feels great. But we still have to finish it. We put ourselves in a great position so far. We’ve still got games to play. We’ll enjoy this one.” - Alex Cora after his team’s win against the Blue Jays in their game on Wednesday.

Jahmai Jones (R) DH

Gleyber Torres (R) 2B

Wenceel Pérez (S) RF

Spencer Torkelson (R) 1B

Riley Greene (L) LF

Andy Ibáñez (R) 3B

Dillon Dingler (R) C

Parker Meadows (L) CF

Javier Báez (R) SS

Jarren Duran (L) LF

Trevor Story (R) SS

Alex Bregman (R) 3B

Masataka Yoshida (L) DH

Romy Gonzalez (R) 2B

Ceddanne Rafaela (R) CF

Nathaniel Lowe (L) 1B

Rob Refsnyder (R) RF

Connor Wong (R) C

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (154)

Home Runs:  Riley Greene (35)

RBI:  Riley Greene (110)

Stolen Bases:  Zach McKinstry (19)

Wins:  Casey Mize (14)

Saves:  Will Vest (21)

ERA:  Alex Lange (0.00)

Batting Average:  Romy Gonzalez (.309)

Hits:  Trevor Story (160)

Home Runs:  Trevor Story (25)

RBI:  Trevor Story (95)

Stolen Bases:  Trevor Story (31)

Wins:  Garrett Crochet (18)

Saves:  Aroldis Chapman (32)

ERA:  Nick Burdi (0.00)

Managers:

Detroit Tigers: A.J. Hinch (5th season)

Boston Red Sox: Álex Cora (5th season)