Detroit Red Wings vs Buffalo Sabres Prediction, Preview and Odds - 10/22/2025

Game Time: 7:30 pm ET, Wednesday, October 22, 2025

Venue:  KeyBank Center, Buffalo, NY

Where to Watch:  TNT, HBO MAX

DraftKings:  Moneyline:  Red Wings +100, Sabres -120; Over/Under:  6.5 goals

Bet365:  Moneyline:  Red Wings +100, Sabres -120; Over/Under:  6.5 goals

BetMGM:  Moneyline:  Red Wings +100, Sabres -120; Over/Under:  6.5 goals

Detroit Red Wings:  5-1-0 (1st place, Atlantic Division)

Buffalo Sabres:  2-4-0 (6th place, Atlantic Division)

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Detroit Red Wings:  5-1-0 last 6

Buffalo Sabres:  2-4-0 last 6

The Red Wings are entering this game with 10 points, a 5-1-0 record overall, and they are 1-0-0 in their road games this season where they will be in this game. They are entering this game off a win against the Edmonton Oilers in their last game, winning that one at home 4-2. Dylan Larkin and Emmitt Finnie each scored 2 goals for them in that one. Dylan Larkin and Lucas Raymond each led the team in assists with 2 while Alex DeBrincat led the team in shots on net in that game with 5. John Gibson was the starting goalie in that game and he allowed 2 goals on 18 shots with 16 saves and a .889 save percentage. Their offense has scored 20 goals this season averaging 3.3 goals per game and their defense has allowed their opponents to score 14 goals against them allowing 2.3 goals per game.

The Sabres are entering this game with 4 points, a 2-4-0 record overall, and they are 2-2-0 in their home games this season where they will be in this game. They are entering this game off a loss against the Montreal Canadiens in their last game, losing that one on the road 4-2. Jiří Kulich and Tyson Kozak each scored 1 goal for them in that one. Jack Quinn, Rasmus Dahlin, and Zach Benson each led the team in assists with 1 while Zach Benson led the team in shots on net in that game with 7. Alex Lyon was the starting goalie in that game and he allowed 3 goals on 30 shots with 27 saves and a .900 sv percentage. Their offense has scored 15 goals this season averaging 2.5 goals per game and their defense has allowed their opponents to score 18 goals against them allowing 3 goals per game.

The current betting odds have the Red Wings listed as a slight underdog in this game according to Draftkings Sportsbook. The Red Wings have looked great in their games this season with their 5-1-0 record overall which has them right at the top of their division in the East. They also have a 1-0-0 road record this season and they have been rolling in their games lately. Meanwhile, the Sabres haven't looked good in their games this season with their 2-4-0 record overall which has them right near the bottom of their division in the East. They haven't looked great on home ice either with their 2-2-0 home record this year. They didn't get off to a great start this season and they finally found 2 wins, but they are off another loss in their last one and it is looking like another season of misery for the Sabres. They were one of the worst teams in the NHL last season and they are trending in that direction once again. The Red Wings are moving in the opposite direction though. They were close to making the playoffs last season, but now they are off to a hot start and are going to be in that conversation this year. Their offense has been rolling in their games lately too, but their defense has also looked a lot better this season. The Red Wings have a ton of momentum on their side coming into this one and they should have no problem beating up on one of the worst teams in the NHl with the way they have been rolling lately. The best way to place a bet here is on the Red Wings to win this game. 

Red Wings Sabres Prediction:  Our NHL Pick for Wednesday, October 22, 2025 (7:30 pm ET start time) is Red Wings 3 Sabres 1.

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Detroit Red Wings: 85-85 (+8.3 units) on the moneyline in all games. 46-37 (+12.8 units) on the moneyline off a win in their previous game. 21-10 (+6.6 units) on the moneyline when playing against a bad team (Win Pct. 25% to 40%). 19-7 OVER against poor possession teams-averaging 3+ less shots on goal than opp.

Buffalo Sabres: 77-93 (-7.4 units) on the moneyline in all games. 16-25 (-11.8 units) on the moneyline against poor starting goalies - saving 89.5% of shots against or less. 51-71 (-9.1 units) on the moneyline against excellent power play teams- scoring on over 17.5% of their chances. 15-8 OVER against poor starting goalies - saving 89.5% of shots against or less.

Detroit Red Wings:  P. Kane (RW) Day To Day - Upper Body. N. Danielson (C) Out - Undisclosed.

Buffalo Sabres:  J. Bryson (D) Day To Day - Upper-body. J. Danforth (RW) Out - Lower Body. M. Kesselring (D) Out - Lower-Body. J. Norris (C) Out - Upper Body. U. Luukkonen (G) Out - Lower-body. J. Greenway (LW) Out - Lower-body. C. Meyer (RW) Out - Knee.

“It is especially difficult when Connor and Leon (Draisaitl) are out there together, because Connor can speed the game up and Leon can slow it down. But Dylan can skate with Connor. Tonight, he accepted the challenge and did a great job.” - Todd McLellan after his team’s win against the Oilers in their game on Sunday.

“We had lots of good opportunities, it wasn’t about opportunities. You know you’re in a tight game and we didn’t defend the rush well on the second goal, and we got caught with a couple of tired people on the third one. I liked our answer right after that to come back and score. We had another couple of good looks, but we were in a tight game and we didn’t find a way to win.” - Lindy Ruff after his team’s loss against the Canadiens in their game on Monday.

LW Emmitt Finnie

C Dylan Larkin

RW Lucas Raymond

LD Ben Chiarot

RD Moritz Seider

G John Gibson

LW Zach Benson

C Jiri Kulich

RW Tage Thompson

LD Bowen Byram

RD Rasmus Dahlin

G Alex Lyon

Points: Dylan Larkin (11)

Goals: Dylan Larkin (5)

Assists: Dylan Larkin (6)

GAA: Cam Talbot (1.78)

Points: Zach Benson (6)

Goals: Jason Zucker (3)

Assists: Zach Benson (6)

GAA: Alex Lyon (2.55)

Coaches:

Detroit Red Wings: Todd McLellan (2nd season)

Buffalo Sabres: Lindy Ruff (2nd season)